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NCT05421208 · ClinicalTrials.gov registry record · NA
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
A NA study of Long COVID and SARS CoV 2 Infection, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05421208: Recruiting NA study of Long COVID and SARS CoV 2 Infection, sponsored by Vanderbilt University Medical Center.
NCT05421208 is a NA study of Long COVID and SARS CoV 2 Infection that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 60 participants, below the 2,187-participant average among 50 other Long COVID trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05421208, a NA study of Long COVID and SARS CoV 2 Infection, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID
Primary Outcome
Evaluate immune cell activation in post-COVID-19 POTS and patients with history of COVID-19 infection without sequelae and correlate this with the degree of decreased PNS activity. The primary endpoint is IL-6 levels
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls
- DIAGNOSTIC_TEST Levels of inflammatory cytokine ( IL-6) in controls
- DIAGNOSTIC_TEST Effect on inflammation after chronic PNS stimulation
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2022-06-01 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT05421208 shows while recruiting
NCT05421208 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 2,187-participant average among 50 other Long COVID trials with a reported enrollment target (97% lower).
The record links to 4 conditions, with Long COVID appearing as the primary indexed condition, and to 3 interventions - of which Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls is the first listed.
NCT05421208 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT05421208 about?
NCT05421208 is a clinical study titled "Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome". The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cau...
What is the current status of trial NCT05421208?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2022-06-01. Estimated completion is 2027-06-30.
What conditions does trial NCT05421208 study?
This clinical trial studies the following conditions: Long COVID, SARS CoV 2 Infection, Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS).
What interventions are being tested in trial NCT05421208?
The interventions under investigation include: Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls (DIAGNOSTIC_TEST), Levels of inflammatory cytokine ( IL-6) in controls (DIAGNOSTIC_TEST), Effect on inflammation after chronic PNS stimulation (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05421208?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05421208 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05421208's enrollment target sits among peer trials
60 27th of 50 higher than 20 of 50 other Long COVID trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Long COVID trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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