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NCT06027255 · ClinicalTrials.gov registry record · NA
Long COVID Immune Profiling
A NA study of Long COVID and Autonomic Dysfunction, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT06027255: Recruiting NA study of Long COVID and Autonomic Dysfunction, sponsored by Vanderbilt University Medical Center.
NCT06027255 is a NA study of Long COVID and Autonomic Dysfunction that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 150 participants, below the 2,185-participant average among 50 other Long COVID trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06027255, a NA study of Long COVID and Autonomic Dysfunction, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation. Preliminary data from the studies shows, that post-COVID-19 POTS patients have reduced parasympathetic (PNS) function. Given that the PNS protects against inflammation, this clinical trial aims to prove that post-COVID-19 POTS is caused by reduced PNS activity, which in turn, contributes to persistent inflammation, orthostatic intolerance, and OI symptoms. The study will evaluate immune cell activation in post-COVID-19 POTS and patients with history of COVID-19 infection without sequelae and correlate this with the degree of decreased PNS activity.
Primary Outcome
Parasympathetic (PNS) function, protects against inflammation. To Evaluate level of inflammation in post-COVID-19 POTS and patients with history of COVID-19 infection without sequelae and correlate this with the degree of decreased PNS activity. The primary endpoint is IL-6 levels
Conditions Studied
Interventions
- DIAGNOSTIC_TEST IL-6
- DIAGNOSTIC_TEST cytokines (IL-17, and IFN-ɣ)
- BEHAVIORAL Compass 31
Study Locations (1)
Tennessee
- Cyndya Shibao - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2024-04-24 |
| Est. Completion | 2027-07-01 |
| Phase | NA |
What NCT06027255 shows while recruiting
NCT06027255 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 2,185-participant average among 50 other Long COVID trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Long COVID appearing as the primary indexed condition, and to 3 interventions - of which IL-6 is the first listed.
NCT06027255 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT06027255 about?
NCT06027255 is a clinical study titled "Long COVID Immune Profiling". Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation. Preliminary data from the studies shows, that post-COVID-19 POTS patients have redu...
What is the current status of trial NCT06027255?
This trial is currently recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2024-04-24. Estimated completion is 2027-07-01.
What conditions does trial NCT06027255 study?
This clinical trial studies the following conditions: Long COVID, Autonomic Dysfunction, POTS - Postural Orthostatic Tachycardia Syndrome.
What interventions are being tested in trial NCT06027255?
The interventions under investigation include: IL-6 (DIAGNOSTIC_TEST), cytokines (IL-17, and IFN-ɣ) (DIAGNOSTIC_TEST), Compass 31 (BEHAVIORAL).
Who is sponsoring clinical trial NCT06027255?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06027255 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06027255's enrollment target sits among peer trials
150 22nd of 50 higher than 28 of 50 other Long COVID trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Long COVID trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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