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Hypertension: full-pipeline trial registry
152 of 472 indexed Hypertension trials are currently recruiting.
Corpus placement: #8 of 28,707 conditions by registered trial count.
472 US clinical trials · 152 currently recruiting · #8 of 28,707 conditions by registered trial count
Hypertension: 472 US clinical trials tracked, 152 recruiting.
Hypertension is the subject of 472 registered US clinical trials on ClinicalTrials.gov, 152 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 15 of these trials.
Enrollment posture brief
Registry condition hypertension
OPEN 152 | RECR 32% | LATE 65 | EARLY 64 | RANK #8 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Leukemia, Myeloid, Acute (32% recruiting · 31 trials)
Hypertension lists 152 open slots (32% of 472 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hypertension on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hypertension is recruiting below its size-band peers.
152 of 472 indexed trials (32.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Hypertension trials is spread across many organizations.
Johns Hopkins University accounts for 15 of 472 trials (3.2%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Hypertension enrolment sits around 168 participants.
Median target enrolment is 168 among the 471 trials that report a genuine target (sentinel values excluded). 170 of those (36.1%) plan for fewer than 100 participants.
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Hypertension research is mostly interventional.
407 interventional and 65 observational studies make up this index (86.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
472 total, page 3 of 10
HTN App for HTN Control and Cardiovascular Health Among African-Americans
Mayo Clinic
NCT06346886
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
University of Texas Southwestern Medical Center
NCT04838678
Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions
University of Texas Southwestern Medical Center
NCT05168605
Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy
Mayo Clinic
NCT06886087
Secondhand Tobacco Smoke and Cardiovascular Disease
University of California, San Francisco
NCT04715568
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices
Dynocardia
NCT04835857
Inspire HER: Inspiring the Heart and Emotions for Radical Health
University of Alabama at Birmingham
NCT06966258
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
University of Colorado, Boulder
NCT05000515
MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors
Clinical Nutrition Research Center, Illinois Institute of Technology
NCT06555952
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
University of Minnesota
NCT06507657
Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes
Johns Hopkins University
NCT06921356
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
University of Massachusetts, Boston
NCT06554340
Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
University of Alabama at Birmingham
NCT05556902
Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health
Skidmore College
NCT06363305
AM vs PM Exercise Training
Michigan State University
NCT06042439
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
Brigham and Women's Hospital
NCT05593055
A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
University of Connecticut
NCT07238556
Targeting Endoplasmic Reticulum Stress in Human Hypertension
University of North Texas Health Science Center
NCT06025630
Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial
Mayo Clinic
NCT06826755
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
VA Office of Research and Development
NCT04163614
How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
University of Nevada, Las Vegas
NCT06817252
Treatment With Aspirin After Preeclampsia: TAP Trial
Malamo Countouris
NCT06281665
Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans
University of Delaware
NCT07071077
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Milton S. Hershey Medical Center
NCT06482853
Assessing Peer Support for Physical Activity in Women With HIV and Hypertension
University of Alabama at Birmingham
NCT07025109
BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement
Massachusetts General Hospital
NCT07091851
Remote Fetal Monitoring in High Risk Pregnancies
Beth Israel Deaconess Medical Center
NCT06822439
Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor
Stanford University
NCT05730465
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Johns Hopkins University
NCT05703386
Reversing Glucose and Lipid-mediated Vascular Dysfunction
University of Kansas Medical Center
NCT04832009
Community-based Implementation of Adapted STAC
University of Wisconsin, Madison
NCT06689930
Sleep Restriction and Parental History of Hypertension
Mayo Clinic
NCT06482814
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
Brigham and Women's Hospital
NCT05030545
Ketone Ester and Salt (KEAS) in Young Adults
Indiana University
NCT05545501
Sleep and Circadian Mechanisms in Hypertension
Oregon Health and Science University
NCT05184933
Ketone Ester And Salt (KEAS) in Older Adults
Indiana University
NCT06868719
Early Time-Restricted Eating in Older Adults With Hypertension
University of Alabama at Birmingham
NCT07135505
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
Freda Patterson
NCT07049783
Remote Vinyasa Yoga Program for Heart Health
West Virginia University
NCT06961981
Metabolic Effects of Angiotensin-(1-7)
Vanderbilt University
NCT02646475
Improving Hypertension Control in Rheumatoid Arthritis
Duke University
NCT05760898
Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)
Benjamin Viglianti
NCT04546126
Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors
University of Illinois at Chicago
NCT06504914
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
University of Kansas Medical Center
NCT04715022
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Indiana University
NCT07119658
Supporting VETerans With Kidney Disease Through Food As Medicine
VA Eastern Colorado Health Care System
NCT07194733
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Vanderbilt University Medical Center
NCT03042988
Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
Wake Forest University
NCT06375694
Sympathetic Mechanisms in Obesity-Crossover Design
Vanderbilt University Medical Center
NCT05312892
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 39 |
| Phase 2 | 25 |
| Phase 3 | 37 |
| Phase 4 | 28 |
Top Sponsors
Named interventions
Most-linked intervention names on Hypertension records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hypertension trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hypertension page
472 registered trials, 152 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 152 Hypertension trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Hypertension trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hypertension condition card totals 472 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.