Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 57 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

Every US clinical trial registered for Non-Small Cell Lung Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

143 US clinical trials · 57 currently recruiting

The research picture

Non-Small Cell Lung Cancer has 143 registered US clinical trials, 57 of them open to new participants right now — about 40% of the total.

57
recruiting participants now
40%
of trials open to enrollment
29
in Phase 3–4 (later-stage)
11
top sponsor: AstraZeneca

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 2,000 participants

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

National Cancer Institute (NCI)

NCT02146170

RECRUITING Phase 3 1,600 participants

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

Summit Therapeutics

NCT05899608

RECRUITING Phase 3 1,410 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pfizer

NCT07222566

RECRUITING 1,200 participants

GEMINI-NSCLC: NSCLC Biomarker Study

Tempus AI

NCT05236114

RECRUITING Phase 3 860 participants

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

AstraZeneca

NCT05211895

RECRUITING Phase 2 840 participants

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

AbbVie

NCT06236438

RECRUITING Phase 3 780 participants

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

Summit Therapeutics

NCT06767514

RECRUITING Phase 3 714 participants

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Pfizer

NCT06758401

RECRUITING Phase 3 675 participants

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

AstraZeneca

NCT06357533

RECRUITING Phase 3 600 participants

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Hoffmann-La Roche

NCT06793215

RECRUITING Phase 2 596 participants

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Bristol-Myers Squibb

NCT07100080

RECRUITING Phase 1 512 participants

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

AbbVie

NCT05005403

RECRUITING 500 participants

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

National Cancer Institute (NCI)

NCT02682667

RECRUITING Phase 2 430 participants

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

AbbVie

NCT07155187

RECRUITING Phase 3 420 participants

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Revolution Medicines

NCT06881784

RECRUITING Phase 1 387 participants

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06917079

RECRUITING Phase 1 365 participants

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

GV20 Therapeutics

NCT05669430

RECRUITING Phase 1 320 participants

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Hoffmann-La Roche

NCT05789082

RECRUITING Phase 2 285 participants

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

National Cancer Institute (NCI)

NCT03412877

RECRUITING Phase 1 280 participants

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

BioNTech SE

NCT05142189

RECRUITING Phase 2 278 participants

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

AstraZeneca

NCT07098338

RECRUITING Phase 3 272 participants

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

University of Texas Southwestern Medical Center

NCT02468024

RECRUITING Phase 1 251 participants

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

Pierre Fabre Medicament

NCT06043817

RECRUITING Phase 1 242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

VM Oncology

NCT03556228

RECRUITING Phase 1 210 participants

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

National Cancer Institute (NCI)

NCT06253520

RECRUITING 200 participants

Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT05424029

RECRUITING Phase 1 195 participants

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

PAQ Therapeutics

NCT07300150

RECRUITING Phase 1 164 participants

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK112 in Patients With Non-Small Cell Lung Cancer

Abbisko Therapeutics Co

NCT06225804

RECRUITING Phase 1 162 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

Pfizer

NCT07227298

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 150 participants

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

Tasca Therapeutics

NCT07030257

RECRUITING Phase 2 150 participants

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

AbbVie

NCT06568939

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING 140 participants

Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers

Scientific Institute San Raffaele

NCT06626243

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING Phase 2 120 participants

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Regeneron Pharmaceuticals

NCT06465329

RECRUITING Phase 1 113 participants

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Fate Therapeutics

NCT07216105

RECRUITING Phase 1 110 participants

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

Eutilex

NCT04903873

RECRUITING Phase 1 100 participants

A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

Cogent Biosciences

NCT07361562

RECRUITING 100 participants

Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy

University of Colorado, Denver

NCT03042221

RECRUITING Phase 1 93 participants

A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

BeiGene

NCT06685718

RECRUITING Phase 1 92 participants

AOH1996 for the Treatment of Refractory Solid Tumors

City of Hope Medical Center

NCT05227326

RECRUITING Phase 2 86 participants

Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity

Memorial Sloan Kettering Cancer Center

NCT01639508

RECRUITING Phase 1 81 participants

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

Avistone Biotechnology Co.

NCT06046495

RECRUITING Phase 2 76 participants

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

Bristol-Myers Squibb

NCT06946797

RECRUITING Phase 2 73 participants

Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer

BicycleTx Limited

NCT06933329

RECRUITING NA 60 participants

Dyadic Yoga Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers: The Testing of a Mobile Application Delivery

M.D. Anderson Cancer Center

NCT06919874

RECRUITING Phase 2 60 participants

Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT07218601

RECRUITING NA 54 participants

High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)

H. Lee Moffitt Cancer Center and Research Institute

NCT06337552

RECRUITING Phase 2 40 participants

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Virginia Commonwealth University

NCT06731413

RECRUITING Phase 2 29 participants

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT07133425

RECRUITING Phase 2 25 participants

Repositioning Immunotherapy in VetArans With Lung Cancer

VA Office of Research and Development

NCT06275360

RECRUITING Phase 1 21 participants

Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC

Icahn School of Medicine at Mount Sinai

NCT06088771

RECRUITING Phase 1 18 participants

A Study Evaluating Neoadjuvant Chemoimmunotherapy With Immunosensitizing Radiation for Borderline Resectable Non-Small Cell Lung Cancer

University of Maryland, Baltimore

NCT06800339

RECRUITING Phase 2 14 participants

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT07428044

RECRUITING Phase 1 12 participants

KRAS-Targeted Vaccine With Nivolumab and Ipilimumab for Patients With NSCLC

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05254184

ACTIVE NOT RECRUITING 5,006 participants

Clinical Effectiveness Assessment of VeriStrat® Testing and Validation of Immunotherapy Tests in NSCLC Subjects

Biodesix

NCT03289780

ACTIVE NOT RECRUITING Phase 3 1,415 participants

Double Blind Placebo Controlled Controlled Study of Adjuvant MEDI4736 In Completely Resected NSCLC

Canadian Cancer Trials Group

NCT02273375

ACTIVE NOT RECRUITING Phase 1 1,410 participants

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Klus Pharma

NCT04152499

ACTIVE NOT RECRUITING Phase 3 1,280 participants

Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]

Hoffmann-La Roche

NCT02486718

ACTIVE NOT RECRUITING Phase 3 1,051 participants

A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

AstraZeneca

NCT05221840

ACTIVE NOT RECRUITING Phase 2 1,000 participants

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

Hoffmann-La Roche

NCT03178552

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 1 857 participants

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

Eli Lilly and Company

NCT03157128

ACTIVE NOT RECRUITING Phase 3 825 participants

A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer

AstraZeneca

NCT03800134

ACTIVE NOT RECRUITING NA 659 participants

Precision Medicine Randomized Clinical Trial Comparing Molecular Tumor Board Assisted Care to Usual Care

Timothy Mullett

NCT05254795

ACTIVE NOT RECRUITING Phase 1 608 participants

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

Boehringer Ingelheim

NCT04886804

ACTIVE NOT RECRUITING Phase 3 603 participants

Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Gilead Sciences

NCT05089734

ACTIVE NOT RECRUITING Phase 3 587 participants

A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

AstraZeneca

NCT04035486

ACTIVE NOT RECRUITING Phase 2 534 participants

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Hoffmann-La Roche

NCT02568267

ACTIVE NOT RECRUITING Phase 3 531 participants

Study of Pembrolizumab (MK-3475) Subcutaneous (SC) Versus Pembrolizumab Intravenous (IV) Administered With Platinum Doublet Chemotherapy in Participants With Metastatic Squamous or Nonsquamous Non-Small Cell Lung Cancer (NSCLC) (MK-3475-A86)

Merck Sharp & Dohme

NCT04956692

ACTIVE NOT RECRUITING Phase 2 528 participants

Phase II Umbrella Study of Novel Anti-cancer Agents in Participants With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy

AstraZeneca

NCT03334617

ACTIVE NOT RECRUITING Phase 1 520 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab

AbbVie

NCT05029882

ACTIVE NOT RECRUITING Phase 1 498 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Genentech

NCT04449874

ACTIVE NOT RECRUITING NA 420 participants

Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)

Razor Genomics

NCT01817192

ACTIVE NOT RECRUITING Phase 3 390 participants

A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection

AstraZeneca

NCT05120349

ACTIVE NOT RECRUITING Phase 3 358 participants

A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

AstraZeneca

NCT04351555

ACTIVE NOT RECRUITING Phase 3 338 participants

A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

Hoffmann-La Roche

NCT06497556

ACTIVE NOT RECRUITING Phase 1 315 participants

Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)

Dizal Pharmaceuticals

NCT03974022

ACTIVE NOT RECRUITING Phase 1 296 participants

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Inhibrx Biosciences

NCT04198766

ACTIVE NOT RECRUITING Phase 2 247 participants

Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD)

AstraZeneca

NCT03944772

ACTIVE NOT RECRUITING Phase 1 200 participants

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Black Diamond Therapeutics

NCT05256290

ACTIVE NOT RECRUITING Phase 2 147 participants

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

Merck Sharp & Dohme

NCT06099782

ACTIVE NOT RECRUITING Phase 1 144 participants

A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors

Deciphera Pharmaceuticals

NCT04892017

ACTIVE NOT RECRUITING Phase 1 106 participants

A Study of NDI 1150-101 in Patients With Solid Tumors

Nimbus Saturn

NCT05128487

ACTIVE NOT RECRUITING 100 participants

Immune and Genomic Markers in ALK+ NSCLC

Massachusetts General Hospital

NCT04881916

ACTIVE NOT RECRUITING 100 participants

A Pilot Study of Blood-based Biomarkers for Response to Immune Checkpoint Inhibitors

Ohio State University Comprehensive Cancer Center

NCT06630429

ACTIVE NOT RECRUITING Phase 1 100 participants

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

Affini-T Therapeutics

NCT06105021

ACTIVE NOT RECRUITING Phase 3 95 participants

Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer

Novartis Pharmaceuticals

NCT05132075

ACTIVE NOT RECRUITING Phase 2 83 participants

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

NeoImmuneTech

NCT04984811

ACTIVE NOT RECRUITING Phase 1 74 participants

Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Novartis Pharmaceuticals

NCT05358249

ACTIVE NOT RECRUITING Phase 3 71 participants

A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)

Hoffmann-La Roche

NCT05170204

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 3 67 participants

A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)

Merck Sharp & Dohme

NCT06698042

ACTIVE NOT RECRUITING Phase 1 61 participants

Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322)

EMD Serono Research & Development Institute

NCT05882734

ACTIVE NOT RECRUITING Phase 2 52 participants

MPDL3280A With Chemoradiation for Lung Cancer

M.D. Anderson Cancer Center

NCT02525757

ACTIVE NOT RECRUITING Phase 1 48 participants

Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer

Dana-Farber Cancer Institute

NCT03122717

ACTIVE NOT RECRUITING Phase 2 43 participants

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Joseph J. Cullen, MD, FACS

NCT02905591

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

Phase Distribution

PhaseTrial count
Phase 1 60
Phase 2 37
Phase 3 29

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

ClinicalTrials.gov lists 143 US studies indexed under Non-Small Cell Lung Cancer, and 57 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Non-Small Cell Lung Cancer shows 29 late-stage studies (Phase 3 and Phase 4 combined) alongside 97 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Non-Small Cell Lung Cancer is led by AstraZeneca with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 143 US clinical trials for Non-Small Cell Lung Cancer, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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