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NCT05593055 · ClinicalTrials.gov registry record · Phase 4
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
A Phase 4 study of Hypertension and Left Ventricular Hypertrophy, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT05593055: Recruiting Phase 4 study of Hypertension and Left Ventricular Hypertrophy, sponsored by Brigham and Women's Hospital.
NCT05593055 is a Phase 4 study of Hypertension and Left Ventricular Hypertrophy that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 75 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05593055, a Phase 4 study of Hypertension and Left Ventricular Hypertrophy, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) antagonist, versus a thiazide-like diuretic, will improve coronary microvascular function and cardiac efficiency, which will associate with improvements in LV structure and function. The investigators will achieve this through a randomized, controlled, basic experimental study involving humans (BESH).
Primary Outcome
Change in myocardial flow reserve (ratio of hyperemic stress myocardial blood flow to rest myocardial blood flow)
Conditions Studied
Interventions
- DRUG Chlorthalidone
- DRUG Eplerenone
- DRUG Potassium
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2023-08-25 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 4 |
What NCT05593055 shows while recruiting
NCT05593055 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 3 interventions - of which Chlorthalidone is the first listed.
NCT05593055 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05593055 about?
NCT05593055 is a clinical study titled "Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension". The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) antagonist, versus a thiazide-like diuretic, will improve coronary microvascular function and cardiac efficiency, which will associate with i...
What is the current status of trial NCT05593055?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 75 participants. The study started on 2023-08-25. Estimated completion is 2027-12-31.
What conditions does trial NCT05593055 study?
This clinical trial studies the following conditions: Hypertension, Left Ventricular Hypertrophy.
What interventions are being tested in trial NCT05593055?
The interventions under investigation include: Chlorthalidone (DRUG), Eplerenone (DRUG), Potassium (DRUG).
Who is sponsoring clinical trial NCT05593055?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05593055 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05593055's enrollment target sits among peer trials
75 323rd of 470 higher than 142 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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