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2026 data Public-data reference. official source

Leukemia, Myeloid, Acute

Open-data reference.

31 US clinical trials · 10 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 600 participants

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Janssen Research & Development

NCT06852222

RECRUITING Phase 1 362 participants

A Study of DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation

Sumitomo Pharma America

NCT04988555

RECRUITING Phase 1 240 participants

Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Aptose Biosciences

NCT03850574

RECRUITING Phase 1 171 participants

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Kura Oncology

NCT06001788

RECRUITING Phase 1 170 participants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

BlossomHill Therapeutics

NCT06501196

RECRUITING Phase 2 120 participants

A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy

OncoVerity

NCT06384261

RECRUITING Phase 2 80 participants

Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Orca Biosystems

NCT07216443

RECRUITING 50 participants

Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML

Wake Forest University Health Sciences

NCT06580106

RECRUITING Phase 1 39 participants

DFP-10917 in Combination With Venetoclax in Relapsed or Refractory Acute Myeloid Leukemia

Delta-Fly Pharma

NCT06382168

RECRUITING Phase 1 16 participants

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

University of Pennsylvania

NCT05945849

ACTIVE NOT RECRUITING Phase 1 196 participants

A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies

Janssen Research & Development

NCT05453903

ACTIVE NOT RECRUITING Phase 3 153 participants

Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia

Actinium Pharmaceuticals

NCT02665065

ACTIVE NOT RECRUITING Phase 3 146 participants

Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation

Institut de Recherches Internationales Servier

NCT03173248

ACTIVE NOT RECRUITING Phase 1 130 participants

A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Celgene

NCT02677922

ACTIVE NOT RECRUITING Phase 1 61 participants

Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia

OncoVerity

NCT04150887

ACTIVE NOT RECRUITING NA 60 participants

Electronic Health Mindfulness-based Music Therapy Intervention for Patients Undergoing Allogeneic Stem Cell Transplantation

University of Miami

NCT05968963

COMPLETED Phase 2 213 participants

An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)

Celgene

NCT02775903

COMPLETED Phase 2 120 participants

An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)

Millennium Pharmaceuticals

NCT02610777

COMPLETED Phase 2 114 participants

Genomic Predictors of Decitabine Response in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes

Washington University School of Medicine

NCT01687400

COMPLETED 100 participants

Use of Saline-Washed Platelet and Red Cell Transfusions in Adult Acute Leukemia

University of Rochester

NCT01976442

COMPLETED Phase 1 92 participants

Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies

Washington University School of Medicine

NCT00241358

COMPLETED Phase 2 55 participants

Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)

Medical College of Wisconsin

NCT00849147

COMPLETED 32 participants

A Study Of Treatment Patterns And Clinical Outcomes In Patients Diagnosed With Acute Myeloid Leukemia Who Received Mylotarg in the Real-World

Pfizer

NCT04337138

COMPLETED Phase 1 31 participants

Azacitidine and Lenalidomide for Acute Myeloid Leukemia

Washington University School of Medicine

NCT01016600

COMPLETED Phase 1 30 participants

A Study of CSL362 in Patients With CD123+ Acute Myeloid Leukemia Currently in Remission

CSL Limited

NCT01632852

COMPLETED Phase 2 30 participants

Investigator Initiated Trial of CPX-351 for Untreated Acute Myeloid Leukemia

Weill Medical College of Cornell University

NCT03335267

COMPLETED Phase 1 24 participants

Decitabine Maintenance for Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndrome (MDS) Post Transplant

Washington University School of Medicine

NCT00986804

COMPLETED Phase 1 15 participants

Combination of Sorafenib and Vorinostat in Poor-risk Acute Myelogenous Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)

Indiana University School of Medicine

NCT00875745

COMPLETED Phase 1 14 participants

CPX-351 Salvage Therapy Followed by Haplo-Cord Transplant for Relapsed/Refractory Leukemia or Myelodysplastic Syndrome

Weill Medical College of Cornell University

NCT03393611

COMPLETED NA 8 participants

Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation

National Heart, Lung, and Blood Institute (NHLBI)

NCT00859586

COMPLETED Phase 1 6 participants

A Study to Assess Safety and Tolerability of CC-486 (ONUREG®, Oral Azacitidine) in Combination Therapy in Participants With Acute Myeloid Leukemia (AML)

Celgene

NCT04887857

Phase Distribution

PhaseTrial count
Early Phase 1 16
Phase 2 7
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Leukemia, Myeloid, Acute Trial Landscape

ClinicalTrials.gov lists 31 US studies indexed under Leukemia, Myeloid, Acute, and 10 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Leukemia, Myeloid, Acute shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 23 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Leukemia, Myeloid, Acute is led by Washington University School of Medicine with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Leukemia, Myeloid, Acute?

PlainTrial tracks 31 US clinical trials for Leukemia, Myeloid, Acute, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Leukemia, Myeloid, Acute?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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