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NCT05030545 · ClinicalTrials.gov registry record · Phase 4
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
A Phase 4 study of Hypertension and Primary Aldosteronism, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05030545: Recruiting Phase 4 study of Hypertension and Primary Aldosteronism, sponsored by Brigham and Women's Hospital.
NCT05030545 is a Phase 4 study of Hypertension and Primary Aldosteronism that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05030545, a Phase 4 study of Hypertension and Primary Aldosteronism, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatment with medications that block aldosterone can reduce that risk. This study is trying to learn whether treatment with a medication that blocks aldosterone can improve heart function in people who make too much aldosterone.
Primary Outcome
The primary outcome is to evaluate the change in MFR, as measured by PET, pre- vs post-6 months of eplerenone therapy
Conditions Studied
Interventions
- DRUG Eplerenone
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-12-15 |
| Est. Completion | 2027-02-28 |
| Phase | Phase 4 |
What NCT05030545 shows while recruiting
NCT05030545 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 1 intervention - of which Eplerenone is the first listed.
NCT05030545 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05030545 about?
NCT05030545 is a clinical study titled "Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study". This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatmen...
What is the current status of trial NCT05030545?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2022-12-15. Estimated completion is 2027-02-28.
What conditions does trial NCT05030545 study?
This clinical trial studies the following conditions: Hypertension, Primary Aldosteronism.
What interventions are being tested in trial NCT05030545?
The interventions under investigation include: Eplerenone (DRUG).
Who is sponsoring clinical trial NCT05030545?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05030545 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05030545's enrollment target sits among peer trials
40 384th of 470 higher than 80 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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