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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 4 of 8
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Medical College of Wisconsin
NCT05752760
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART)
Virginia Commonwealth University
NCT06062966
Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function
Auburn University
NCT07489105
An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure
InterShunt Technologies
NCT06859970
Staged Kidney Transplantation During Combined Heart/Kidney Transplantation
Cedars-Sinai Medical Center
NCT06877169
Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing
Yale University
NCT07281014
Assessment of Safety and Accuracy of the Microtech System in Patients Undergoing Left Ventricular Assist Device Implantation
Microtech Medical Technologies
NCT06682910
Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients
Baylor Research Institute
NCT03383419
Mechanisms of Semaglutide Therapy in Heart Failure Patients
University Medical Centre Ljubljana
NCT06541509
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
David Lanfear
NCT07054489
A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System
Vectorious Medical Technologies
NCT06147336
Metformin for Pulmonary Hypertension HFpEF
University of California, San Francisco
NCT03629340
Cardiac Power Output in Cardiogenic Shock Patients
University of Chicago
NCT05700617
BiVACOR® Total Artificial Heart Early Feasibility Study
BiVACOR
NCT06174103
Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
Brigham and Women's Hospital
NCT06980623
Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)
Brigham and Women's Hospital
NCT07390110
Characterizing Outcomes and Real-World Experience of Cardiac Physiologic Pacing (The CORE-CPP Study)
Medtronic Cardiac Rhythm and Heart Failure
NCT06606288
Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)
CVRx
NCT04502316
Patient-Reported Outcomes as an Indicator of Disease Transitions in Heart Failure
Intermountain Health Care
NCT04264845
Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure
NYU Langone Health
NCT06457152
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
Medtronic
NCT04489225
Ventricular Remodeling and Heart Failure After Myocardial Infarction: A Community Study
Mayo Clinic
NCT02047396
Patient Education Video to Reduce OTC NSAIDs
Carilion Clinic
NCT06575205
Personalized Therapy Study - Attain Stability Quad Post-Approval Study
Medtronic
NCT04024943
TRISCEND II Pivotal Trial
Edwards Lifesciences
NCT04482062
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Decision Support for Heart Failure Prescribing
University of Colorado, Denver
NCT06293794
RESPONDER-HF Trial
Corvia Medical
NCT05425459
Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
Impulse Dynamics
NCT03970343
Reduce Lap-hf Trial II
Corvia Medical
NCT03088033
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
V-Wave
NCT03499236
LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System.
Boston Scientific Corporation
NCT04790344
Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients
University of Rochester
NCT04818645
Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
Vanderbilt University Medical Center
NCT04481919
ASCEND CSP IDE Study
Abbott Medical Devices
NCT06830746
Psychosocial Syndemics of Heart Failure
Washington University School of Medicine
NCT04637776
Randomized Clinical Trial to Improve Mobility After Hospitalization
University of Pennsylvania
NCT05736484
Assessment of Combined CCM and ICD Device in HFrEF
Impulse Dynamics
NCT05855135
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
EBR Systems
NCT02922036
Factors Associated With Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Non-LBBB ECG Pattern
University of Rochester
NCT06977217
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
University of British Columbia
NCT03575910
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
Indiana University
NCT05601817
The Role of 4 Different Consent Approaches on a Pilot Study to Increase Cardiac Rehabilitation Attendance
Baystate Medical Center
NCT07123480
XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)
XVIVO Perfusion
NCT05881278
Mobile Application for Patient Engagement and Physician-Directed Remote Management of Heart Failure
University of Michigan
NCT06750549
Artificial Intelligence Mobile Health Trial Of A Digital Platform To Optimize GDMT Using Wearable Sensors
Biofourmis
NCT04191330
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
Edwards Lifesciences
NCT05686317
Informational Nudge to Improve Heart Failure Prescribing
VA Office of Research and Development
NCT05986695
Lifestyle Intervention for Heart Failure
M.D. Anderson Cancer Center
NCT00633633
Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
Edwards Lifesciences
NCT03523416
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.