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NCT07390110 · ClinicalTrials.gov registry record
Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)
A clinical trial of Heart Failure and Type 2 Diabetes, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- 25,664
- Enrollment target
- 1
- Study location
NCT07390110: Active study of Heart Failure and Type 2 Diabetes, sponsored by Brigham and Women's Hospital.
NCT07390110 is a study of Heart Failure and Type 2 Diabetes that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 25,664 participants, above the 1,984-participant average among 397 other Heart Failure trials with a reported enrollment target (1194% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07390110, a study of Heart Failure and Type 2 Diabetes, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 25,664 participants
- Enrollment target
- 1
- Study location
Study Summary
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.
Primary Outcome
To evaluate the comparative effect of oral semaglutide vs sitagliptin on the composite of worsening heart failure events or all-cause mortality in patients with heart failure with preserved ejection fraction in clinical practice.
Conditions Studied
Interventions
- DRUG Sitagliptin
- DRUG Oral semaglutide
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25,664 participants |
| Start Date | 2026-01-24 |
| Est. Completion | 2026-05-11 |
What the registry record for NCT07390110 still lists
NCT07390110 is an observational study that tracks outcomes without assigning an intervention. Its 25,664 participants enrollment target places it among the larger protocols in the corpus, above the 1,984-participant average among 397 other Heart Failure trials with a reported enrollment target (1194% higher).
The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Sitagliptin is the first listed.
NCT07390110 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07390110 about?
NCT07390110 is a clinical study titled "Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)". Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such s...
What is the current status of trial NCT07390110?
This trial is currently active not recruiting. The enrollment target is 25,664 participants. The study started on 2026-01-24. Estimated completion is 2026-05-11.
What conditions does trial NCT07390110 study?
This clinical trial studies the following conditions: Heart Failure, Type 2 Diabetes.
What interventions are being tested in trial NCT07390110?
The interventions under investigation include: Sitagliptin (DRUG), Oral semaglutide (DRUG).
Who is sponsoring clinical trial NCT07390110?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07390110 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07390110's enrollment target sits among peer trials
25,664 8th of 397 higher than 390 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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-
Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
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