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NCT04481919 · ClinicalTrials.gov registry record · Phase 2
Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
A Phase 2 study of Heart Failure and Acute Heart Failure, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- Phase 2
- Development phase
- 474
- Enrollment target
- 2
- Study locations
NCT04481919 is a Phase 2 study of Heart Failure and Acute Heart Failure that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 474 participants, below the 2,048-participant average among 397 other Heart Failure trials with a reported enrollment target (77% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT04481919, a Phase 2 study of Heart Failure and Acute Heart Failure, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 474 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF. Participants will be recruited following an initial standard evaluation in the ED and randomized in a 1:1 fashion to structured usual care or protocolized diuretic therapy guided by urinary sodium.
Conditions Studied
Interventions
- DRUG Protocolized diuretic therapy
Study Locations (2)
Tennessee
- VA Tennessee Valley Health Service - Nashville
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 474 participants |
| Start Date | 2022-05-01 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04481919
The ClinicalTrials.gov registry entry for NCT04481919 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 474 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,048-participant average among 397 other Heart Failure trials with a reported enrollment target (77% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which Protocolized diuretic therapy is the first listed.
NCT04481919 reports 2 study locations spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT04481919 about?
NCT04481919 is a clinical study titled "Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)". This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF. Participants will be recruited following an initial standard evaluation in the ED and randomized in a 1:1 fashion to structured usual care or protocolized d...
What is the current status of trial NCT04481919?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 474 participants. The study started on 2022-05-01. Estimated completion is 2026-12-31.
What conditions does trial NCT04481919 study?
This clinical trial studies the following conditions: Heart Failure, Acute Heart Failure.
What interventions are being tested in trial NCT04481919?
The interventions under investigation include: Protocolized diuretic therapy (DRUG).
Who is sponsoring clinical trial NCT04481919?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04481919 being conducted?
This trial has 2 study locations across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.