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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 3 of 8
Heart Failure Precision Medicine Study
University of California, Davis
NCT04196842
Brain Volume and Cardiac Function in Heart Failure
Johns Hopkins University
NCT06623344
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
West Virginia School of Osteopathic Medicine
NCT06049420
Identifying Markers of Exercise Training in Heart Failure
Stanford University
NCT05696652
IEEM-Heat and Heart Failure
University of Texas Southwestern Medical Center
NCT06961929
Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure
Virginia Commonwealth University
NCT05177822
Studies of Neuregulin/ERBB Signaling in Human Heart
Douglas B. Sawyer
NCT02820233
His Bundle Pacing in Bradycardia and Heart Failure
Yong-Mei Cha
NCT03008291
Lymphatic System Stimulation in Heart Failure
Rutgers, The State University of New Jersey
NCT05834400
A Study of Paramedic HF Management
Mayo Clinic
NCT06874556
Mechanisms of Diuretic Resistance in Heart Failure, Aim 1
Yale University
NCT05323487
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
Washington University School of Medicine
NCT05562167
Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines
M.D. Anderson Cancer Center
NCT02962661
Voice Analysis for Monitoring Patients With Heart Failure
Noah Labs
NCT06566911
Inspiratory Muscle Training in HFpEF
Mayo Clinic
NCT06510231
Use of Point-of-Care Ultrasound (POCUS) to Reduce Hospital Length of Stay in Patients With Heart Failure ( POCUSHF )
Florida International University
NCT06965712
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
Tufts Medical Center
NCT06253104
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
XVIVO Perfusion
NCT06895070
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
AstraZeneca
NCT06651970
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Northwestern University
NCT05719714
Ertugliflozin in Chronic Heart Failure
Yale University
NCT04438213
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Noah Labs
NCT07443670
Effects of Acute and Chronic Empagliflozin Heart Failure
Yale University
NCT05553938
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
University of Texas Southwestern Medical Center
NCT06130059
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Sardocor
NCT04703842
Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction
Duke University
NCT06733012
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Virginia Commonwealth University
NCT05194111
Impella Reverse Remodeling in End-Stage Heart Failure
Columbia University
NCT06800716
Enhanced Nutritional Optimization in LVAD Trial
Columbia University
NCT05655910
Fluid Guided Heart Failure Treatment at the Cleveland Clinic
Bodyport
NCT07205120
Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
Yale University
NCT06209359
In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm
Inova Health Care Services
NCT06675448
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
Stanford University
NCT06080074
Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)
Gradient Denervation Technologies
NCT06052072
Symptom Care at Home-Heart Failure
Emory University
NCT04347759
Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
Yale University
NCT05753059
A Nurse-Led Weight Monitoring Intervention For Heart Failure Quality of LIfe and Self-Care
Lee Anne Siegmund
NCT07184541
A Study to Evaluate Breathing Muscle Training in Cardiac Rehab
Mayo Clinic
NCT04984473
Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver
Denver Health and Hospital Authority
NCT07435662
Hemodynamic Monitoring to Prevent Adverse Events foLlowing cardiOgenic Shock Trial
Inova Health Care Services
NCT04419480
Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients
Maya Ignaszewski
NCT05537467
Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease
Anita Saraf
NCT06260059
Digital Health Physical Activity Program for Older Family Care Partners of Patents With Heart Failure
University of Colorado, Denver
NCT05852509
TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure
University of Illinois at Chicago
NCT06473532
Quantifying New Heart Muscle Cells
Weill Medical College of Cornell University
NCT06587165
Colchicine in Acutely Decompensated HFREF
University of Virginia
NCT06286423
Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV
University of Washington
NCT07105007
Cardiopulmonary Stress Testing (CPET) AlloSure Study
Baylor Research Institute
NCT04656080
Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII)
Foundry Innovation & Research 1, Limited (FIRE1)
NCT05763407
Empagliflozin in ESKD - A Feasibility Study
University of Mississippi Medical Center
NCT05687058
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.