Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,707 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,707 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Enrollment posture brief
Registry condition heart-failure
OPEN 164 | RECR 41% | LATE 47 | EARLY 63 | RANK #13 | SPON 15
Volume-matched condition peers
Nearest open-share peer: Erectile Dysfunction (41% recruiting · 34 trials)
Heart Failure lists 164 open slots (41% of 399 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
-
Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
-
Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 5 of 8
Acute Kidney Injury Genomics and Biomarkers in TAVR Study
University of Texas Southwestern Medical Center
NCT02791880
Identifying Targets of Maladaptive Metabolic Responses in Heart Failure
AdventHealth Translational Research Institute
NCT03032627
PARTNER 3 Trial - Mitral Valve in Valve
Edwards Lifesciences
NCT03193801
Physiological Effects Ketone Ester in Heart
The Cleveland Clinic
NCT05924802
Reduce Lap-hf Randomized Trial I
Corvia Medical
NCT02600234
A-SPIRE Heart Failure: Utilizing Health Tags to Identify Patients at Risk for Hospital Readmissions
University of Rochester
NCT04550052
Impact of Vericiguat on Hemodynamics of Heart Failure
University of Colorado, Denver
NCT05704478
DASH Diet in Heart Failure Outpatients
University of California, Davis
NCT05117086
Early Feasibility Evaluation of the AccuCinch® Ventricular Restoration System in Patients With Heart Failure and Reduced Ejection Fraction
Ancora Heart
NCT03533517
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Massachusetts General Hospital
NCT06576050
Effects of Triiodothyronine (T3) in Ischemic Heart Failure
Emory University
NCT05384847
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
University of Pennsylvania
NCT04323189
AB-1002 in Patients With Class III Heart Failure
AskBio
NCT04179643
Reduce Lap-hfref Trial
Corvia Medical
NCT03093961
Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip
samir kapadia
NCT04729933
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
Abiomed
NCT05291884
Type 2 Diabetes With Antiplatelet Drugs
Tabula Rasa HealthCare
NCT05053828
Effectiveness of Oral Anticoagulants in Elderly Patients With Non-Valvular Atrial Fibrillation and Heart Failure
Bristol-Myers Squibb
NCT03508271
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Intervention With Vitamin D and Omega-3 Supplements and Incident Heart Failure
Brigham and Women's Hospital
NCT02271230
Levels of Inflammation in People With Cardiovascular Disease (POSEIDON)
Novo Nordisk A/S
NCT06122961
Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure
Duke University
NCT03035474
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
Brigham and Women's Hospital
NCT02787044
Clinical Decision Support for Medication Management and Adherence
Duke University
NCT00979225
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Geisinger Clinic
NCT05990296
Evaluation of ECG Transmission and AI Models Using Apple Watch ECGs and Symptoms Data Collected Using a Mayo iPhone App
Mayo Clinic
NCT05324566
EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
Boehringer Ingelheim
NCT03057977
Global Electrical Heterogeneity and Clinical Outcomes
Larisa Tereshchenko
NCT03210883
Risk EValuation And Its Impact on ClinicAL Decision Making and Outcomes in Heart Failure
Yale University
NCT03845660
A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines
Pfizer's Upjohn has merged with Mylan to form Viatris
NCT00232180
Hemodynamic-GUIDEd Management of Heart Failure
Abbott Medical Devices
NCT03387813
Occluded Artery Trial (OAT)
NYU Langone Health
NCT00004562
InSync Model 8040 (InSync) and InSync III Model 8042 (InSync III) Registry
Medtronic Cardiac Rhythm and Heart Failure
NCT00273182
Quadripolar Pacing Post Approval Study
Abbott Medical Devices
NCT01555619
SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients
Abbott Medical Devices
NCT00940888
Warfarin and Antiplatelet Therapy in Chronic Heart Failure
US Department of Veterans Affairs
NCT00007683
Personalized CRT - PSR
Medtronic
NCT03723265
Better Effectiveness After Transition - Heart Failure
University of California, Los Angeles
NCT01360203
Patient-Reported Outcome Measurement in Heart Failure Clinic
Stanford University
NCT04164004
Quantitative Evaluation of the Progression of Liver Disease, Using ShearWaveTM
Baylor Research Institute
NCT02070315
CardioMEMS HF System Post Approval Study
Abbott Medical Devices
NCT02279888
Pharmacist Intervention to Decrease Medication Errors in Heart Disease Patients (The PILL-CVD Study)
Vanderbilt University Medical Center
NCT00632021
Heart And Lung Failure - Pediatric INsulin Titration Trial
Boston Children's Hospital
NCT01565941
Strategic Management to Optimize Response To Cardiac Resynchronization Therapy
Boston Scientific Corporation
NCT03089281
REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)
Medtronic Cardiac Rhythm and Heart Failure
NCT00271154
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
Kaiser Permanente
NCT04351880
Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
Cytokinetics
NCT01300013
Increasing Exercise Capacity of Patients With Heart Failure by Wii Gaming
Linkoeping University
NCT01785121
Retrospective Experience Of CIED Implantation
Elutia
NCT04351269
A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure
Boehringer Ingelheim
NCT04157751
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure page
399 registered trials, 164 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 164 Heart Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Abbott Medical Devices sponsors the most Heart Failure trials on record, review their full trial history before evaluating a specific study. See Abbott Medical Devices's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure condition card totals 399 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.