Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
NCT05636176 · View on ClinicalTrials.gov ↗
Study Summary
This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Ziltivekimab
Study Locations (20)
California
- InvivoCure -2 — Alhambra
- National Heart Institute Cal — Beverly Hills
- Valley Clinical Trials — Covina
- Scripps Memorial Hospital La Jolla — La Jolla
- Purushotham & Akther Kotha MD, inc. — La Mesa
- VA Loma Linda Hlthcr Sys — Loma Linda
- Biopharma Clinical Research Services, LLC — Los Angeles
- VA Greater Los Angeles Hlthcare System — Los Angeles
- VAGrtrLosAngelesHlthcareSystem — Los Angeles
- Valley Clinical Trials, Inc. — Northridge
- UCI Health — Orange
- Stanford Univ School of Med — Palo Alto
- San Diego Cardiac Center — San Diego
- North America Research Institute — San Dimas
Alabama
- Advanced Cardiovascular, LLC — Alexander City
- Eastern Shore Rsrch Inst, LLC — Fairhope
- Heart Center Rsrch_Hunstville — Huntsville
Arizona
- Banner University Medical Ctr — Phoenix
- Banner University Medical Ctr — Phoenix
Arkansas
- Cardiology & Medicine Clinic — Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5,600 participants |
| Start Date | 2023-05-08 |
| Est. Completion | 2027-07-02 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05636176
The ClinicalTrials.gov registry entry for NCT05636176 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 5,600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05636176 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05636176 about?
NCT05636176 is a clinical study titled "A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation". This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine in...
What is the current status of trial NCT05636176?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 5,600 participants. The study started on 2023-05-08. Estimated completion is 2027-07-02.
What conditions does trial NCT05636176 study?
This clinical trial studies the following conditions: Heart Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05636176?
The interventions under investigation include: Placebo (DRUG), Ziltivekimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05636176?
This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05636176 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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