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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,963 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,963 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Open enrollment snapshot
Heart Failure has 399 registered US clinical trials, 164 of them open to new participants right now, about 41% of the total.
- 164
- recruiting participants now
- 41%
- of trials open to enrollment
- 47
- in Phase 3-4 (later-stage)
- 15
- top sponsor: Abbott Medical Devices
Corpus placement: #13 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 2 of 8
Evaluating the Reach of Clinical Decision Support for Patients With Heart Failure
University of Colorado, Denver
NCT06847906
: Vascular Function in Health and Disease
Russell Richardson
NCT02966665
Pulmonary Artery Catheter in Cardiogenic Shock Trial
Tufts Medical Center
NCT05485376
Project 4: ACHIEVE PATHFINDER
Henry Ford Health System
NCT06070428
Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
Nuwellis
NCT05318105
Project 2: ACHIEVE- HF
Henry Ford Health System
NCT05330221
iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
University of Illinois at Chicago
NCT06205225
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
Electrophysiology Research Foundation
NCT04160000
Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)
VDI Technologies
NCT06641362
Evaluation of the Jarvik 2000 Left Ventricular Assist System With Post-Auricular Connector--Destination Therapy Study
Jarvik Heart
NCT01627821
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Merck Sharp & Dohme
NCT05714085
The STOP-MED CTRCD Trial
University Health Network, Toronto
NCT06183437
Home-based Cardiac Rehabilitation in Heart Failure
University of Texas Southwestern Medical Center
NCT06349941
Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies
Jia-Rong Wu
NCT05548413
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Procyrion
NCT05677100
Effect of a Quality Improvement Initiative to Address Social Determinants of Health on Rehospitalization Rates in Patients With Heart Failure
Saint Luke's Health System
NCT05388097
Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
Baystate Medical Center
NCT05925634
The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)
EBR Systems
NCT07098858
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
University of Texas Southwestern Medical Center
NCT06593327
Cardiovascular Kidney and Metabolic Health Assessment and Patient Empowerment
Aventyn
NCT07403669
Optimizing Beta Blocker Dosage in Women While Using the Wearable Cardioverter Defibrillator
Zoll Medical Corporation
NCT04504188
Promoting Well-being and Health in Heart Failure
Massachusetts General Hospital
NCT04829617
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
Syed Hamza Mufarrih
NCT07053475
Use of ReDS Technology in Patients With Acute Heart Failure
Icahn School of Medicine at Mount Sinai
NCT04305717
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
VA Office of Research and Development
NCT04982419
AI-Guided Left Bundle Branch Area Pacing
Mayo Clinic
NCT07206602
Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure
Johns Hopkins University
NCT06364644
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Bristol-Myers Squibb
NCT06122779
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
Oregon Health and Science University
NCT06461962
Sensor-controlled Digital Game for Heart Failure Self-management: A Clinical Trial
University of Texas at Austin
NCT05056129
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients
Children's National Research Institute
NCT03822442
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Novo Nordisk A/S
NCT06979362
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Northwestern University
NCT06517186
Mind Your Heart-II
The Miriam Hospital
NCT05431192
Diffusion MRI in Heart Failure
Massachusetts General Hospital
NCT02973633
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
Lancaster General Hospital
NCT06688396
Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Hari Narayan
NCT04262830
CV Imaging of Metabolic Interventions
The Cleveland Clinic
NCT05650307
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Alessandro Doria
NCT06217302
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
Yale University
NCT07273838
Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure
University of Florida
NCT02368041
A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure
Tufts Medical Center
NCT05627440
His-Bundle Corrective Pacing in Heart Failure
University of Rochester
NCT05265520
Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure
University of Florida
NCT06979726
Symptom Burden and Health Related Quality of Life of Cancer Patients With Concurrent Heart Failure
M.D. Anderson Cancer Center
NCT06656715
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Bettina Mittendorfer
NCT07083557
Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation
University of Pennsylvania
NCT06291922
Supporting Health in Veterans With Heart Failure
Florida State University
NCT05839067
LVAD Conditioning for Cardiac Recovery
Stavros G Drakos
NCT03238690
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Heart Failure right now
164 recruiting of 399 indexed (41% open).
Phase mix: 47 late (III/IV) vs 63 early (I/II) (balanced across stages).
Top sponsor: Abbott Medical Devices (15 trials), 9 others listed. 50 shown below, recruiting first. #13 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Heart Failure?
PlainTrial tracks 399 US clinical trials for Heart Failure, of which 164 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Failure?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.