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RECRUITING NA

Left vs Left Randomized Clinical Trial

NCT05650658 · View on ClinicalTrials.gov ↗

Study Summary

The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure due to left ventricular systolic dysfunction (LVEF≤50%) and with either a wide QRS (≥130 ms) or with/anticipated \>40% pacing who are already receiving current standard heart failure pharmacological therapy.

Interventions

  • DEVICE His/LBBP
  • DEVICE BiVP

Study Locations (20)

Florida

  • Heart Rhythm Solutions — Davie
  • University of Florida Jacksonville — Jacksonville
  • Mount Sinai Medical Center of Florida, Inc. — Miami Beach
  • Cleveland Clinic Florida — Palm Beach Gardens
  • Florida Heart and Vascular, LLC dba Florida Heart Rhythm Specialist, PLLC — South Pasadena
  • University of South Florida — Tampa

Illinois

  • Rush University — Chicago
  • University of Chicago — Chicago
  • Northwestern University — Evanston
  • CIS Clinical Research Corporation — Naperville

Arizona

  • Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ — Gilbert
  • University of Arizona College of Medicine- Phoenix — Tucson

Colorado

  • University of Colorado (Anschutz Medical Campus) — Denver
  • South Denver Cardiology Associates — Littleton

Connecticut

  • Hartford Hospital — Hartford
  • Yale University — New Haven

Arkansas

  • University of Arkansas for Medical Sciences (UAMS) — Little Rock

California

  • University of California San Diego — La Jolla

Indiana

  • Trustees of Indiana University — Indianapolis

Trial Details

FieldValue
Enrollment Target 2,136 participants
Start Date 2023-09-13
Est. Completion 2029-06-30
Phase NA

Sponsor

Baylor College of Medicine

678 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05650658

The ClinicalTrials.gov registry entry for NCT05650658 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,136 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Baylor College of Medicine, which has 678 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions — of which His/LBBP is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05650658 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, Illinois, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05650658 about?

NCT05650658 is a clinical study titled "Left vs Left Randomized Clinical Trial". The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and...

What is the current status of trial NCT05650658?

This trial is currently recruiting. It is a NA study. The enrollment target is 2,136 participants. The study started on 2023-09-13. Estimated completion is 2029-06-30.

What conditions does trial NCT05650658 study?

This clinical trial studies the following conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05650658?

The interventions under investigation include: His/LBBP (DEVICE), BiVP (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05650658?

This trial is sponsored by Baylor College of Medicine, which has 678 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05650658 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial