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NCT06991257 · ClinicalTrials.gov registry record · Phase 2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
A Phase 2 study of Heart Failure, sponsored by Pfizer.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 620
- Enrollment target
- 20
- Study locations
NCT06991257: Recruiting Phase 2 study of Heart Failure, sponsored by Pfizer.
NCT06991257 is a Phase 2 study of Heart Failure that is actively recruiting participants, run by Pfizer. The registered enrollment target is 620 participants, below the 2,047-participant average among 397 other Heart Failure trials with a reported enrollment target (70% lower). The trial reports 20 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06991257, a Phase 2 study of Heart Failure, is actively recruiting participants, sponsored by Pfizer.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 620 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
Primary Outcome
Adjudicated cardiovascular death and worsening heart failure events through 36 weeks.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Low Dose PF-07328948
- DRUG Medium Dose PF-07328948
- DRUG High Dose PF-07328948
Study Locations (20)
Illinois
- NMH Clinical Research Unit - Chicago
- Northwestern Memorial HealthCare - Arkes Pavilion - Chicago
- Northwestern Memorial HealthCare - Feinberg Pavilion - Chicago
- Northwestern Memorial HealthCare - Galter Pavilion - Chicago
- Northwestern Memorial Hospital Investigational Drug Service (IDS) - Chicago
- Northwestern University - Evanston
- Chicago Medical Research - Hazel Crest
Florida
- FWD Clinical Research - Boca Raton
- Jacksonville Center for Clinical Research - Jacksonville
- Infinite Clinical Research - Miami
- Flourish Research Acquisition, LLC dba Flourish Research - North Miami - Miami
- Amavita Research Services - North Miami Beach
- Clinical Site Partners, LLC dba Flourish Research - Winter Park
California
- National Heart Institute - Beverly Hills
- Orange County Research Center - Lake Forest
- Comprehensive Cardiovascular Care - Santa Maria
- FOMAT Medical Research - Santa Maria
Indiana
- NexGen Research - Fort Wayne
- Reid Physician Associates - Richmond
Maryland
- Ascension Saint Agnes Heart Care - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 620 participants |
| Start Date | 2025-06-19 |
| Est. Completion | 2027-12-14 |
| Phase | Phase 2 |
What NCT06991257 shows while recruiting
NCT06991257 is an interventional study that assigns participants to a tested intervention. The registered 620 participants enrollment target is mid-sized for trials with a published cap, below the 2,047-participant average among 397 other Heart Failure trials with a reported enrollment target (70% lower).
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT06991257 names 20 study sites across 5 states, led by Illinois, Florida, California.
Frequently Asked Questions
What is clinical trial NCT06991257 about?
NCT06991257 is a clinical study titled "A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)". The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
What is the current status of trial NCT06991257?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 620 participants. The study started on 2025-06-19. Estimated completion is 2027-12-14.
What conditions does trial NCT06991257 study?
This clinical trial studies the following conditions: Heart Failure.
What interventions are being tested in trial NCT06991257?
The interventions under investigation include: Placebo (DRUG), Low Dose PF-07328948 (DRUG), Medium Dose PF-07328948 (DRUG), High Dose PF-07328948 (DRUG).
Who is sponsoring clinical trial NCT06991257?
This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06991257 being conducted?
This trial has 20 study locations across California, Florida, Illinois, Indiana, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06991257's enrollment target sits among peer trials
620 89th of 397 higher than 308 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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