Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

NCT06736574 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

Interventions

  • DRUG Placebo
  • DRUG Omecamtiv Mecarbil (OM)

Study Locations (20)

California

  • National Heart Institute — Beverly Hills
  • UC San Diego Health - Sulpizio Cardiovascular Center — La Jolla
  • Nutrition Research Center (SPH) — Loma Linda
  • Keck Medical Center of USC (outpatient clinic) — Los Angeles
  • UCLA Medical Center Cardiovascular Clinic — Los Angeles
  • University of California, Irvine Medical Center — Orange
  • Sutter Institute for Medical Research (SIMR) — Sacramento
  • UC Davis Health — Sacramento
  • San Diego Cardiac Center — San Diego
  • California Pacific Medical Center Van Ness Campus — San Francisco
  • Kaiser Permanente Santa Clara — Santa Clara
  • Stanford University Hospital / Stanford Health Care — Stanford
  • Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center — Torrance

Connecticut

  • Cardiology Associates of Fairfield County, P.C — Bridgeport
  • Hartford Hospital — Hartford
  • Yale New Haven Health Heart & Vascular Center Outpatient Services — New Haven

Alabama

  • Advanced Cardiovascular, LLC — Alexander City
  • University of Alabama at Birmingham — Birmingham

Arizona

  • Pima Heart and Vascular Clinical Research — Tucson

Colorado

  • Rocky Mountain Regional VA Medical Center — Aurora

Trial Details

FieldValue
Enrollment Target 1,800 participants
Start Date 2024-12-19
Est. Completion 2027-12
Phase Phase 3

Sponsor

Cytokinetics

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06736574

The ClinicalTrials.gov registry entry for NCT06736574 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,800 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cytokinetics, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06736574 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Connecticut, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06736574 about?

NCT06736574 is a clinical study titled "Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction". The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.

What is the current status of trial NCT06736574?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,800 participants. The study started on 2024-12-19. Estimated completion is 2027-12.

What conditions does trial NCT06736574 study?

This clinical trial studies the following conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06736574?

The interventions under investigation include: Placebo (DRUG), Omecamtiv Mecarbil (OM) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06736574?

This trial is sponsored by Cytokinetics, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06736574 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial