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Head and Neck Cancer: early-phase trial registry
89 of 260 indexed Head and Neck Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #39 of 28,707 conditions by registered trial count.
260 US clinical trials · 89 currently recruiting · #39 of 28,707 conditions by registered trial count
Head and Neck Cancer: 260 US clinical trials tracked, 89 recruiting.
Head and Neck Cancer is the subject of 260 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 137 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.
Enrollment posture brief
Registry condition head-and-neck-cancer
OPEN 89 | RECR 34% | LATE 13 | EARLY 137 | RANK #39 | SPON 19
Volume-matched condition peers
Nearest open-share peer: Recurrent Malignant Solid Neoplasm (34% recruiting · 38 trials)
Head and Neck Cancer lists 89 open slots (34% of 260 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Head and Neck Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Head and Neck Cancer is recruiting below its size-band peers.
89 of 260 indexed trials (34.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Head and Neck Cancer trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 19 of 260 trials (7.3%). 124 distinct sponsors appear on at least one study for this condition label.
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Most Head and Neck Cancer trials plan to enrol fewer than 100 people.
Median target enrolment is 53 among the 251 trials that report a genuine target (sentinel values excluded). 165 of those (65.7%) plan for fewer than 100 participants.
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Head and Neck Cancer research is mostly interventional.
213 interventional and 47 observational studies make up this index (81.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
260 total, page 2 of 6
Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck
University of Rochester
NCT04805528
Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery
Wake Forest University Health Sciences
NCT06607406
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07209189
ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy
Abramson Cancer Center at Penn Medicine
NCT05318027
Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
Natalie Lockney
NCT05156060
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
University of Maryland, Baltimore
NCT06088381
Prehabilitation Protocol for Head and Neck Cancer Patients
University of Miami
NCT07318220
Microbiome in Head and Neck Squamous Cell Carcinoma
University of Colorado, Denver
NCT05837221
Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Alain Algazi
NCT03708224
Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
University of California, Irvine
NCT06580002
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Vanderbilt University Medical Center
NCT05650710
PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivors
University of Miami
NCT06124508
Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
VLP Therapeutics
NCT06736379
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
Memgen
NCT05076760
A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
NCT04722523
Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction
Case Comprehensive Cancer Center
NCT07110142
Pilot Study of Management of Facial Paralysis in the Oncologic Patient: Nerve Transfer Techniques to Improve Facial Function and Quality of Life
M.D. Anderson Cancer Center
NCT06667427
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy
University of California, San Francisco
NCT05273307
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer
University of Chicago
NCT07065630
RAPA-201 Therapy of Solid Tumors
Rapa Therapeutics
NCT05144698
Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
UNC Lineberger Comprehensive Cancer Center
NCT06096038
Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)
M.D. Anderson Cancer Center
NCT07101432
Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer
University of Chicago
NCT05526924
A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer
University of Chicago
NCT05420948
Supporting Treatment Resilience With Optimized Nutrition and Guided Exercise in Head and Neck Cancer Patients Undergoing Chemoradiation
Renown Health
NCT07160296
Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers
Brigham and Women's Hospital
NCT05553782
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Case Comprehensive Cancer Center
NCT06627270
NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
University of Colorado, Denver
NCT06919666
Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC
Dana-Farber Cancer Institute
NCT05726370
Phase II Panitumumab-IRDye800 in Head & Neck Cancer
University of Alabama at Birmingham
NCT04511078
PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC
Glenn J. Hanna
NCT06239220
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
University of California, Irvine
NCT07447050
Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
University of California, Davis
NCT06722508
Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study
Vanessa Torrecillas
NCT07264036
Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment
University of Utah
NCT06108089
Intraoral Hypothermia Device for Preserving Taste During Radiation
Henry Ford Health System
NCT06579248
3D Specimen Maps for RT Planning
Vanderbilt University Medical Center
NCT05743569
A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
NCT05544136
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Washington University School of Medicine
NCT06904365
A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
TScan Therapeutics
NCT05812027
A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors
TScan Therapeutics
NCT05973487
RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
Radiation Therapy Oncology Group
NCT00956007
Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial
Rutgers, The State University of New Jersey
NCT04713449
Observational Study of Dental Outcomes in Head and Neck Cancer Patients
Wake Forest University Health Sciences
NCT02057510
Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia
M.D. Anderson Cancer Center
NCT01266044
Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients
M.D. Anderson Cancer Center
NCT02253238
Implementation and Effectiveness Trial of HN-STAR
Wake Forest University Health Sciences
NCT04208490
Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients
Wake Forest University Health Sciences
NCT05325970
A Feasibility Study to Further the Development of Lung Cancer-based Precision Medicine
University of Arkansas
NCT02597738
Supportive Oncology Care At Home RCT
Massachusetts General Hospital
NCT04544046
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 63 |
| Phase 2 | 74 |
| Phase 3 | 11 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Head and Neck Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Head and Neck Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Head and Neck Cancer page
260 registered trials, 89 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 89 Head and Neck Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Head and Neck Cancer trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Head and Neck Cancer condition card totals 260 registered trials; most-linked intervention cisplatin; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.