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Endometrial Cancer clinical trials
108 of 188 indexed Endometrial Cancer trials are currently recruiting.
188 US clinical trials · 108 currently recruiting
Endometrial Cancer is the subject of 188 registered US clinical trials on ClinicalTrials.gov, 108 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 118 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.
The research picture
Endometrial Cancer has 188 registered US clinical trials, 108 of them open to new participants right now, about 57% of the total.
- 108
- recruiting participants now
- 57%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 17
- top sponsor: Memorial Sloan Kettering Cancer Center
Active & Recent Trials
188 total, page 3 of 4
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Tanabe Pharma America
NCT06943521
PROton Therapy for Post Surgical Treatment of GYNecologic Cancer
Abramson Cancer Center at Penn Medicine
NCT05758688
Avelumab and M1774 in ARID1A-mutated Endometrial Cancer
Panagiotis Konstantinopoulos, MD, PhD
NCT06518564
Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome
Jessica D. St. Laurent, MD
NCT07220239
Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer
M.D. Anderson Cancer Center
NCT05819892
CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer
Abramson Cancer Center at Penn Medicine
NCT07278986
A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer
Memorial Sloan Kettering Cancer Center
NCT07318415
Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors
Radiopharm Theranostics
NCT05799274
Estrogen, Diet, Genetics and Endometrial Cancer
Memorial Sloan Kettering Cancer Center
NCT00587886
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
Exelixis
NCT03170960
Improving Care After Inherited Cancer Testing
Vanderbilt-Ingram Cancer Center
NCT04763915
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
Merck Sharp & Dohme
NCT06132958
Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
Gilead Sciences
NCT06486441
Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health
University of Alabama at Birmingham
NCT04000880
A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
Eli Lilly and Company
NCT04188548
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
Agenus
NCT03860272
Selective Surgical Staging for the Treatment of Endometrial Cancer Based on Intraoperative Consultation
Frederick R. Ueland, M.D.
NCT02658565
Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]
Karyopharm Therapeutics
NCT03555422
First in Human Study of IMGN151 in Recurrent Gynaecological Cancers
AbbVie
NCT05527184
Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence
University of Washington
NCT04930159
Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.
Incyte Corporation
NCT04463771
Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention
M.D. Anderson Cancer Center
NCT05677048
A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies
Xencor
NCT05032040
ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
Uswm CT
NCT04044859
Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer
University of Oklahoma
NCT03526432
Diet, Hepcidin, and Chemotherapy RDI
George Washington University
NCT06483997
A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors
NextCure
NCT05572684
TH1902 in Patients With Advanced Solid Tumors
Theratechnologies
NCT04706962
A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma
M.D. Anderson Cancer Center
NCT01797523
Risk Factors for Endometrial Cancer in Black Women
Memorial Sloan Kettering Cancer Center
NCT00514254
Abemaciclib and Letrozole to Treat Endometrial Cancer
Gynecologic Oncology Group
NCT04393285
Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer
University of Oklahoma
NCT03932409
Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer
Memorial Sloan Kettering Cancer Center
NCT04569773
Positron Lymphography Via Intracervical 18F-FDG Injection for Pre-surgical Lymphatic Mapping in Stage IB1 Cervical Cancer and High-grade Endometrial Cancer
Memorial Sloan Kettering Cancer Center
NCT02285192
Letrozole and RAD001 With Advanced or Recurrent Endometrial Cancer
M.D. Anderson Cancer Center
NCT01068249
A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer
Hoffmann-La Roche
NCT05634499
The EndoBARR Trial (Endometrial Bevacizumab, Atezolizumab, Rucaparib)
Medical College of Wisconsin
NCT03694262
Journey Ahead: Enhancing Coping and Communication for Women Diagnosed With Gynecological Cancer
Rutgers, The State University of New Jersey
NCT05220033
Genetic Testing in African Americans
Augusta University
NCT05591131
A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT03285152
A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)
Dana-Farber Cancer Institute
NCT03835819
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
GlaxoSmithKline
NCT06710847
Activity and Cancer Survivorship Exercise Pilot
University of Iowa
NCT07283029
TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer
Washington University School of Medicine
NCT03955978
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer
M.D. Anderson Cancer Center
NCT05761951
Continuation of Follow-up of DES-Exposed Cohorts
National Cancer Institute (NCI)
NCT00340600
Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
National Cancer Institute (NCI)
NCT01793545
Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer
AEterna Zentaris
NCT01767155
Study of XB002 in Subjects With Solid Tumors (JEWEL-101)
Exelixis
NCT04925284
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 74 |
| Phase 2 | 44 |
| Phase 3 | 14 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Endometrial Cancer Trial Landscape
188 indexed Endometrial Cancer studies · 108 recruiting (57%).
Phase mix: 15 late (III/IV) vs 118 early (I/II).
Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Endometrial Cancer?
PlainTrial tracks 188 US clinical trials for Endometrial Cancer, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Endometrial Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.