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ClinicalTrials.gov 108 recruiting now official registry

Endometrial Cancer clinical trials

108 of 188 indexed Endometrial Cancer trials are currently recruiting.

188 US clinical trials · 108 currently recruiting

Endometrial Cancer is the subject of 188 registered US clinical trials on ClinicalTrials.gov, 108 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 118 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.

The research picture

Endometrial Cancer has 188 registered US clinical trials, 108 of them open to new participants right now, about 57% of the total.

108
recruiting participants now
57%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 174Phase 244Phase 314Phase 41

Active & Recent Trials

188 total, page 3 of 4

RECRUITING Phase 1 27 participants

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Tanabe Pharma America

NCT06943521

RECRUITING Phase 2 25 participants

PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

Abramson Cancer Center at Penn Medicine

NCT05758688

RECRUITING Phase 2 25 participants

Avelumab and M1774 in ARID1A-mutated Endometrial Cancer

Panagiotis Konstantinopoulos, MD, PhD

NCT06518564

RECRUITING NA 25 participants

Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome

Jessica D. St. Laurent, MD

NCT07220239

RECRUITING Phase 1 21 participants

Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer

M.D. Anderson Cancer Center

NCT05819892

RECRUITING Early Phase 1 10 participants

CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer

Abramson Cancer Center at Penn Medicine

NCT07278986

RECRUITING NA 10 participants

A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT07318415

RECRUITING Phase 1 9 participants

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

Radiopharm Theranostics

NCT05799274

ACTIVE NOT RECRUITING 1,315 participants

Estrogen, Diet, Genetics and Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT00587886

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING NA 720 participants

Improving Care After Inherited Cancer Testing

Vanderbilt-Ingram Cancer Center

NCT04763915

ACTIVE NOT RECRUITING Phase 3 710 participants

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

Merck Sharp & Dohme

NCT06132958

ACTIVE NOT RECRUITING Phase 3 640 participants

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)

Gilead Sciences

NCT06486441

ACTIVE NOT RECRUITING NA 603 participants

Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health

University of Alabama at Birmingham

NCT04000880

ACTIVE NOT RECRUITING Phase 1 500 participants

A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer

Eli Lilly and Company

NCT04188548

ACTIVE NOT RECRUITING Phase 1 499 participants

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Agenus

NCT03860272

ACTIVE NOT RECRUITING NA 401 participants

Selective Surgical Staging for the Treatment of Endometrial Cancer Based on Intraoperative Consultation

Frederick R. Ueland, M.D.

NCT02658565

ACTIVE NOT RECRUITING Phase 3 263 participants

Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]

Karyopharm Therapeutics

NCT03555422

ACTIVE NOT RECRUITING Phase 1 256 participants

First in Human Study of IMGN151 in Recurrent Gynaecological Cancers

AbbVie

NCT05527184

ACTIVE NOT RECRUITING NA 252 participants

Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence

University of Washington

NCT04930159

ACTIVE NOT RECRUITING Phase 2 206 participants

Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.

Incyte Corporation

NCT04463771

ACTIVE NOT RECRUITING NA 205 participants

Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention

M.D. Anderson Cancer Center

NCT05677048

ACTIVE NOT RECRUITING Phase 2 170 participants

A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies

Xencor

NCT05032040

ACTIVE NOT RECRUITING Phase 1 120 participants

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Uswm CT

NCT04044859

ACTIVE NOT RECRUITING Phase 2 110 participants

Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer

University of Oklahoma

NCT03526432

ACTIVE NOT RECRUITING 100 participants

Diet, Hepcidin, and Chemotherapy RDI

George Washington University

NCT06483997

ACTIVE NOT RECRUITING Phase 1 97 participants

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors

NextCure

NCT05572684

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 2 62 participants

A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma

M.D. Anderson Cancer Center

NCT01797523

ACTIVE NOT RECRUITING 59 participants

Risk Factors for Endometrial Cancer in Black Women

Memorial Sloan Kettering Cancer Center

NCT00514254

ACTIVE NOT RECRUITING Phase 2 53 participants

Abemaciclib and Letrozole to Treat Endometrial Cancer

Gynecologic Oncology Group

NCT04393285

ACTIVE NOT RECRUITING Phase 1 45 participants

Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer

University of Oklahoma

NCT03932409

ACTIVE NOT RECRUITING 43 participants

Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT04569773

ACTIVE NOT RECRUITING Phase 1 42 participants

Positron Lymphography Via Intracervical 18F-FDG Injection for Pre-surgical Lymphatic Mapping in Stage IB1 Cervical Cancer and High-grade Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT02285192

ACTIVE NOT RECRUITING Phase 2 42 participants

Letrozole and RAD001 With Advanced or Recurrent Endometrial Cancer

M.D. Anderson Cancer Center

NCT01068249

ACTIVE NOT RECRUITING Phase 2 30 participants

A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer

Hoffmann-La Roche

NCT05634499

ACTIVE NOT RECRUITING Phase 2 30 participants

The EndoBARR Trial (Endometrial Bevacizumab, Atezolizumab, Rucaparib)

Medical College of Wisconsin

NCT03694262

ACTIVE NOT RECRUITING NA 30 participants

Journey Ahead: Enhancing Coping and Communication for Women Diagnosed With Gynecological Cancer

Rutgers, The State University of New Jersey

NCT05220033

ACTIVE NOT RECRUITING NA 21 participants

Genetic Testing in African Americans

Augusta University

NCT05591131

ACTIVE NOT RECRUITING NA 19 participants

A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT03285152

ACTIVE NOT RECRUITING Phase 2 18 participants

A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

Dana-Farber Cancer Institute

NCT03835819

ACTIVE NOT RECRUITING Phase 1 14 participants

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

GlaxoSmithKline

NCT06710847

ACTIVE NOT RECRUITING NA 10 participants

Activity and Cancer Survivorship Exercise Pilot

University of Iowa

NCT07283029

ACTIVE NOT RECRUITING Phase 1 10 participants

TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer

Washington University School of Medicine

NCT03955978

ACTIVE NOT RECRUITING Phase 2 8 participants

Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer

M.D. Anderson Cancer Center

NCT05761951

COMPLETED 10,805 participants

Continuation of Follow-up of DES-Exposed Cohorts

National Cancer Institute (NCI)

NCT00340600

COMPLETED 1,932 participants

Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples

National Cancer Institute (NCI)

NCT01793545

COMPLETED Phase 3 511 participants

Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer

AEterna Zentaris

NCT01767155

COMPLETED Phase 1 269 participants

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Exelixis

NCT04925284

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

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Phase Distribution

PhaseTrial count
Phase 1 74
Phase 2 44
Phase 3 14
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Endometrial Cancer Trial Landscape

188 indexed Endometrial Cancer studies · 108 recruiting (57%).

Phase mix: 15 late (III/IV) vs 118 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Endometrial Cancer?

PlainTrial tracks 188 US clinical trials for Endometrial Cancer, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Endometrial Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.