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NCT03932409 · ClinicalTrials.gov registry record · Phase 1
Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer
A Phase 1 study of Endometrial Cancer, sponsored by University of Oklahoma.
- Active
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
- 2
- Study locations
NCT03932409: Active Phase 1 study of Endometrial Cancer, sponsored by University of Oklahoma.
NCT03932409 is a Phase 1 study of Endometrial Cancer that is active but no longer recruiting, run by University of Oklahoma. The registered enrollment target is 45 participants, below the 524-participant average among 181 other Endometrial Cancer trials with a reported enrollment target (91% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03932409, a Phase 1 study of Endometrial Cancer, is active but no longer recruiting, sponsored by University of Oklahoma.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this single arm, open label study is to evaluate the feasibility of pembrolizumab combined with radiation administered to the upper part of the vagina (vaginal cuff brachytherapy) followed by three cycles of pembrolizumab and chemotherapy in patients with endometrial cancer.
Primary Outcome
defined as completion of 3 cycles of pembrolizumab combined with dose dense paclitaxel and carboplatin chemotherapy
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Paclitaxel
- RADIATION Vaginal cuff brachytherapy (VCB)
Study Locations (2)
Louisiana
- LSU Health New Orleans - New Orleans
Oklahoma
- Stephenson Cancer Center - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2020-02-19 |
| Est. Completion | 2026-09 |
| Phase | Phase 1 |
What the registry record for NCT03932409 still lists
NCT03932409 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 524-participant average among 181 other Endometrial Cancer trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 4 interventions - of which Pembrolizumab is the first listed.
NCT03932409 reports a single indexed study location in Louisiana, Oklahoma.
Frequently Asked Questions
What is clinical trial NCT03932409 about?
NCT03932409 is a clinical study titled "Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer". The purpose of this single arm, open label study is to evaluate the feasibility of pembrolizumab combined with radiation administered to the upper part of the vagina (vaginal cuff brachytherapy) followed by three cycles of pembrolizumab and chemotherapy in patients with endometrial cancer.
What is the current status of trial NCT03932409?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2020-02-19. Estimated completion is 2026-09.
What conditions does trial NCT03932409 study?
This clinical trial studies the following conditions: Endometrial Cancer.
What interventions are being tested in trial NCT03932409?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Paclitaxel (DRUG), Vaginal cuff brachytherapy (VCB) (RADIATION).
Who is sponsoring clinical trial NCT03932409?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03932409 being conducted?
This trial has 2 study locations across Louisiana, Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Endometrial Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03932409's enrollment target sits among peer trials
45 131st of 181 higher than 50 of 181 other Endometrial Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Endometrial Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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