Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
NCT06486441 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).
Conditions Studied
Interventions
- DRUG Doxorubicin
- DRUG Paclitaxel
- DRUG Sacituzumab govitecan-hziy
Study Locations (20)
California
- City of Hope — Duarte
- UC San Diego Medical Center — La Jolla
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles
- Stanford Women's Cancer Center — Palo Alto
- Kaiser Permanente Medical Center — Vallejo
Florida
- Florida Cancer Specialists — Fort Myers
- University of Florida — Gainesville
- Baptist MD Anderson Cancer Center — Jacksonville
Connecticut
- Hartford HealthCare Cancer Institute at Hartford Hospital — Hartford
- Yale University School of Medicine — New Haven
Georgia
- Winship Cancer Institute, Emory University — Atlanta
- Lewis Cancer & Research Pavilion at St. Joseph's/Candler Health System — Savannah
Illinois
- Northwestern Memorial Hospital — Chicago
- University of Chicago Medical Center — Chicago
Kentucky
- Baptist Health Lexington — Lexington
- Norton Cancer Institute — Louisville
Arkansas
- University of Arkansas for Medical Sciences — Little Rock
Colorado
- University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) — Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 640 participants |
| Start Date | 2024-08-28 |
| Est. Completion | 2029-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06486441
The ClinicalTrials.gov registry entry for NCT06486441 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 640 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gilead Sciences, which has 190 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 3 interventions — of which Doxorubicin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06486441 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06486441 about?
NCT06486441 is a clinical study titled "Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)". The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives ...
What is the current status of trial NCT06486441?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 640 participants. The study started on 2024-08-28. Estimated completion is 2029-06.
What conditions does trial NCT06486441 study?
This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06486441?
The interventions under investigation include: Doxorubicin (DRUG), Paclitaxel (DRUG), Sacituzumab govitecan-hziy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06486441?
This trial is sponsored by Gilead Sciences, which has 190 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06486441 being conducted?
This trial has 20 study locations across Arkansas, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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