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ClinicalTrials.gov 108 recruiting now official registry

Endometrial Cancer clinical trials

108 of 188 indexed Endometrial Cancer trials are currently recruiting.

188 US clinical trials · 108 currently recruiting

Endometrial Cancer is the subject of 188 registered US clinical trials on ClinicalTrials.gov, 108 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 118 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.

The research picture

Endometrial Cancer has 188 registered US clinical trials, 108 of them open to new participants right now, about 57% of the total.

108
recruiting participants now
57%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 174Phase 244Phase 314Phase 41

Active & Recent Trials

188 total, page 2 of 4

RECRUITING Phase 2 200 participants

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Jazz Pharmaceuticals

NCT06695845

RECRUITING NA 192 participants

Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)

Northwestern University

NCT05743517

RECRUITING Phase 2 180 participants

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Dana-Farber Cancer Institute

NCT03675893

RECRUITING Phase 1 160 participants

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Eikon Therapeutics

NCT07262619

RECRUITING Phase 1 150 participants

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

Normunity AccelCo

NCT07182149

RECRUITING Phase 1 148 participants

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Alliance Foundation Trials

NCT04486352

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING Phase 1 132 participants

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06974110

RECRUITING Phase 1 130 participants

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Sairopa B.V.

NCT05856981

RECRUITING NA 120 participants

Mindfulness in Endometrial and Cervical Cancer

St. Louis University

NCT04512144

RECRUITING Phase 1 115 participants

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

ModeX Therapeutics, An OPKO Health Company

NCT06239194

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING Phase 1 100 participants

Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer

University of Chicago

NCT04683653

RECRUITING 100 participants

DESTINY-PANTUMOUR04

AstraZeneca

NCT07124000

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING Phase 1 90 participants

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

Portage Biotech

NCT04969315

RECRUITING Phase 1 90 participants

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05103683

RECRUITING Phase 1 80 participants

A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

Context Therapeutics

NCT06515613

RECRUITING Phase 2 75 participants

A Study of Elacestrant Alone or in Combination With Abemaciclib in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT07209449

RECRUITING NA 70 participants

ASk Questions in GYnecologic Oncology (ASQ-GYO)

Ira Winer

NCT06339827

RECRUITING NA 70 participants

Hugo™ Robotic-Assisted Surgery (RAS) System in Gynecological Subjects (Embrace Gynecology)

Medtronic - MITG

NCT07120945

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 2 68 participants

Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies

University of Utah

NCT05979610

RECRUITING Phase 2 62 participants

Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery

Memorial Sloan Kettering Cancer Center

NCT04774419

RECRUITING Phase 1 61 participants

177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

Radiopharm Theranostics

NCT07189871

RECRUITING Phase 2 60 participants

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

Iovance Biotherapeutics

NCT06481592

RECRUITING Phase 1 60 participants

Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer

National Cancer Institute (NCI)

NCT06253494

RECRUITING NA 60 participants

Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers

Jonsson Comprehensive Cancer Center

NCT06538337

RECRUITING Phase 1 58 participants

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

UNC Lineberger Comprehensive Cancer Center

NCT05542407

RECRUITING Phase 2 50 participants

Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer

Alessandro Santin

NCT03832361

RECRUITING Phase 2 50 participants

A Study of Ivonescimab in People With Endometrial and Cervical Cancers

Memorial Sloan Kettering Cancer Center

NCT06925724

RECRUITING Phase 1 50 participants

BP1001-A in Patients With Advanced or Recurrent Solid Tumors

Bio-Path Holdings

NCT04196257

RECRUITING NA 50 participants

Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial

Medical College of Wisconsin

NCT07227077

RECRUITING 45 participants

Endometrial Cancer, Risk Factors and Prevention Strategies: Perspectives of Patients and At-Risk Women

M.D. Anderson Cancer Center

NCT06409052

RECRUITING 40 participants

Vaginal Fluid Collection for Detection of Endometrial Cancer

Innovis

NCT06294886

RECRUITING Phase 2 40 participants

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

Faeth Therapeutics

NCT06463028

RECRUITING Phase 1 37 participants

Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma

University of Alabama at Birmingham

NCT05559879

RECRUITING Phase 1 36 participants

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Washington University School of Medicine

NCT06795009

RECRUITING Early Phase 1 36 participants

A Study of a Weight Loss Intervention in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT06751589

RECRUITING 35 participants

The Better, Harder, Faster, Stronger Study

Wake Forest University Health Sciences

NCT07220512

RECRUITING Phase 2 32 participants

ALPINE: Maintenance Letrozole/Abemaciclib

Dana-Farber Cancer Institute

NCT06366347

RECRUITING Phase 2 32 participants

Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin

Dana-Farber Cancer Institute

NCT06677190

RECRUITING NA 30 participants

ctDNA Testing to Inform Standard-of-Care Treatment Decisions in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT07270666

RECRUITING NA 30 participants

Multimedia Aid for Genetic Testing in Gynecologic Oncology

UNC Lineberger Comprehensive Cancer Center

NCT07084168

RECRUITING NA 30 participants

Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy

Northwestern University

NCT05990426

RECRUITING NA 30 participants

Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

Dana-Farber Cancer Institute

NCT04997096

RECRUITING Phase 2 29 participants

Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer

Aadi Bioscience

NCT05997017

RECRUITING Early Phase 1 28 participants

A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer

Memorial Sloan Kettering Cancer Center

NCT05691010

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Phase Distribution

PhaseTrial count
Phase 1 74
Phase 2 44
Phase 3 14
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Endometrial Cancer Trial Landscape

188 indexed Endometrial Cancer studies · 108 recruiting (57%).

Phase mix: 15 late (III/IV) vs 118 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Endometrial Cancer?

PlainTrial tracks 188 US clinical trials for Endometrial Cancer, of which 108 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Endometrial Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.