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A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer
NCT05634499 · View on ClinicalTrials.gov ↗
Study Summary
This Phase II, global, single-arm study is designed to evaluate the efficacy, safety, and pharmacokinetics of giredestrant monotherapy in participants with Grade 1 endometrioid endometrial cancer.
Conditions Studied
Interventions
- DRUG Giredestrant
Study Locations (12)
Quebec
- Jewish General Hospital — Montreal
- McGill University Health Centre - Glen Site — Montreal
Other
- Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice — Gliwice
- Swietokrzyskie Centrum Onkologii — Kielce
Arkansas
- University of Arkansas for Medical Sciences — Little Rock
Florida
- Mount Sinai Medical Center — Miami Beach
Minnesota
- Minnesota Oncology Minneapolis — Minneapolis
New Jersey
- Englewood Health/Hematology Oncology Practice of Englewood (HOPE) — Englewood
Pennsylvania
- Western Pennsylvania Hospital — Pittsburgh
Texas
- Texas Oncology, P.A. - Fort Worth — Fort Worth
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2023-06-27 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05634499
The ClinicalTrials.gov registry entry for NCT05634499 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 1 intervention — of which Giredestrant is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05634499 reports 12 study locations spanning 10 distinct geographic areas — top geographies include Quebec, Other, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05634499 about?
NCT05634499 is a clinical study titled "A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer". This Phase II, global, single-arm study is designed to evaluate the efficacy, safety, and pharmacokinetics of giredestrant monotherapy in participants with Grade 1 endometrioid endometrial cancer.
What is the current status of trial NCT05634499?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2023-06-27. Estimated completion is 2026-06-30.
What conditions does trial NCT05634499 study?
This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05634499?
The interventions under investigation include: Giredestrant (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05634499?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05634499 being conducted?
This trial has 12 study locations across Arkansas, Florida, Minnesota, New Jersey, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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