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2026 data Public-data reference. official source

Mesothelioma

Open-data reference.

47 US clinical trials · 27 currently recruiting

Active & Recent Trials

RECRUITING 1,000 participants

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

National Cancer Institute (NCI)

NCT01950572

RECRUITING 1,000 participants

Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

National Cancer Institute (NCI)

NCT03830229

RECRUITING 800 participants

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

National Cancer Institute (NCI)

NCT04431024

RECRUITING Phase 1 764 participants

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Genmab

NCT05579366

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING NA 397 participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Dana-Farber Cancer Institute

NCT04115254

RECRUITING Phase 1 336 participants

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Bristol-Myers Squibb

NCT05245500

RECRUITING Phase 1 336 participants

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

Vivace Therapeutics

NCT04665206

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING 275 participants

Rapid Autopsy and Procurement of Cancer Tissue

National Cancer Institute (NCI)

NCT01851395

RECRUITING Phase 1 260 participants

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

IDEAYA Biosciences

NCT07277413

RECRUITING Phase 1 242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

VM Oncology

NCT03556228

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING NA 240 participants

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

Dana-Farber Cancer Institute

NCT03683680

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING Phase 1 140 participants

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

Nuvectis Pharma

NCT05873686

RECRUITING Phase 2 130 participants

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

Brigham and Women's Hospital

NCT05730816

RECRUITING Phase 1 112 participants

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Perspective Therapeutics

NCT06710756

RECRUITING Phase 1 103 participants

A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors

BridGene Biosciences

NCT06452160

RECRUITING Phase 1 100 participants

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

National Cancer Institute (NCI)

NCT06885697

RECRUITING Phase 1 77 participants

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

A&G Pharmaceutical

NCT05627960

RECRUITING Phase 2 64 participants

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

Memorial Sloan Kettering Cancer Center

NCT06057935

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 2 56 participants

Olaparib in Patients With HRD Malignant Mesothelioma

University of Chicago

NCT04515836

RECRUITING Phase 1 52 participants

Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

Baylor College of Medicine

NCT05932199

RECRUITING Phase 2 33 participants

A Study of Sacituzumab Govitecan in People With Mesothelioma

Memorial Sloan Kettering Cancer Center

NCT06477419

RECRUITING NA 30 participants

Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma

University of Chicago

NCT07126509

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 1 137 participants

A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors

Novartis Pharmaceuticals

NCT04857372

ACTIVE NOT RECRUITING Phase 1 126 participants

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Novartis Pharmaceuticals

NCT05544929

ACTIVE NOT RECRUITING Phase 1 113 participants

Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin

Memorial Sloan Kettering Cancer Center

NCT02414269

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING Phase 2 65 participants

Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma

Memorial Sloan Kettering Cancer Center

NCT00715611

ACTIVE NOT RECRUITING Phase 1 57 participants

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

TCR2 Therapeutics

NCT03907852

ACTIVE NOT RECRUITING Phase 1 41 participants

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05571839

ACTIVE NOT RECRUITING Phase 2 30 participants

Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03918252

ACTIVE NOT RECRUITING Phase 1 19 participants

A Study of SGN-MesoC2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06466187

ACTIVE NOT RECRUITING Phase 1 6 participants

A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

TCR2 Therapeutics

NCT05451849

COMPLETED Phase 2 188 participants

Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy

National Cancer Institute (NCI)

NCT00004547

COMPLETED Phase 2 48 participants

Pemetrexed Plus Gemcitabine as Front-Line Chemotherapy for Patients With Malignant Pleural or Peritoneal Mesothelioma

Eli Lilly and Company

NCT00061477

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 2 37 participants

A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)

University of Florida

NCT03207347

COMPLETED Phase 2 29 participants

Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma

Columbia University

NCT00859469

COMPLETED Phase 1 27 participants

Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide

Columbia University

NCT00629343

COMPLETED Phase 1 16 participants

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors

Masonic Cancer Center, University of Minnesota

NCT00703638

COMPLETED Phase 2 8 participants

Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)

University of Alabama at Birmingham

NCT01204203

COMPLETED Phase 1 6 participants

Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors

Nagla Abdel Karim

NCT03023319

Phase Distribution

PhaseTrial count
Early Phase 1 25
Phase 2 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mesothelioma Trial Landscape

ClinicalTrials.gov lists 47 US studies indexed under Mesothelioma, and 27 of those are currently open to recruitment — roughly 57% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Mesothelioma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 38 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Mesothelioma is led by National Cancer Institute (NCI) with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 47 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mesothelioma?

PlainTrial tracks 47 US clinical trials for Mesothelioma, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mesothelioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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