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Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.
NCT04463771 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, open-label, nonrandomized, Phase 2 umbrella study of retifanlimab in participants who have advanced or metastatic endometrial cancer that has progressed on or after platinum-based chemotherapy. retifanlimab will be administered as monotherapy or in combination with other immunotherapy or targeted agents.
Conditions Studied
Interventions
- DRUG INCAGN02385
- DRUG INCAGN02390
- DRUG retifanlimab
- DRUG epacadostat
- DRUG pemigatinib
Study Locations (20)
Florida
- Broward Health Medical Center — Fort Lauderdale
- Miami Cancer Institute — Miami
- Mount Sinai Medical Center Comprehensive Cancer Center — Miami Beach
- Advent Health Medical Group-Orlando 2501 — Orlando
- H. Lee Moffitt Cancer Center and Research Institute Hospital — Tampa
Arizona
- Honorhealth — Phoenix
- Arizona Oncology Associates — Tucson
California
- UCLA Medical Hematology & Oncology — Los Angeles
- Olive View Med Ctr — Sylmar
Missouri
- Midwest Cancer Care — Kansas City
- Washington University — St Louis
Alaska
- Alaska Womens Cancer Care Akwcc — Anchorage
Georgia
- Georgia Cancer Center — Augusta
Michigan
- Barbara Ann Karmanos Cancer Hospital — Detroit
Minnesota
- Minnesota Oncology-Maplewood — Coon Rapids
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2021-01-26 |
| Est. Completion | 2026-07-10 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04463771
The ClinicalTrials.gov registry entry for NCT04463771 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 206 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 5 interventions — of which INCAGN02385 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04463771 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04463771 about?
NCT04463771 is a clinical study titled "Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.". This is a multicenter, open-label, nonrandomized, Phase 2 umbrella study of retifanlimab in participants who have advanced or metastatic endometrial cancer that has progressed on or after platinum-based chemotherapy. retifanlimab will be administered as monotherapy or in combination with other immun...
What is the current status of trial NCT04463771?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 206 participants. The study started on 2021-01-26. Estimated completion is 2026-07-10.
What conditions does trial NCT04463771 study?
This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04463771?
The interventions under investigation include: INCAGN02385 (DRUG), INCAGN02390 (DRUG), retifanlimab (DRUG), epacadostat (DRUG), pemigatinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04463771?
This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04463771 being conducted?
This trial has 20 study locations across Alaska, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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