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NCT05725239 · ClinicalTrials.gov registry record · NA
taVNS or TMS or Both for Depression
A NA study of Depression, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT05725239: Recruiting NA study of Depression, sponsored by Medical University of South Carolina.
NCT05725239 is a NA study of Depression that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 24 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05725239, a NA study of Depression, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of the taVNS. The investigators think this combined method might treat depressive symptoms better than either alone. This study is in person at the Institute of Psychiatry in downtown Charleston on the MUSC campus. First, participants will have a screening session and then will have 6 treatment days total where participants will receive either VNS treatment alone, TMS treatment alone, or both at the same time. The treatment that participants start with will be randomized, and they will have 2 treatment days of each combination.
Primary Outcome
The Hamilton Depression Rating Scale (HDRS) is a commonly used clinician-administered depression rating scale to assess severity of depressive symptoms. The HDRS has a possible score range of 0-52. The higher the HDRS score, the more severe the depressive symptoms are in that patient.
Conditions Studied
Interventions
- DEVICE Transcranial Magnetic Stimulation
- DEVICE Vagus Nerve Stimulation
Study Locations (1)
South Carolina
- Medical University of South Carolina Institute of Psychiatry - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2023-03-14 |
| Est. Completion | 2026-07-01 |
| Phase | NA |
What NCT05725239 shows while recruiting
NCT05725239 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Transcranial Magnetic Stimulation is the first listed.
NCT05725239 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT05725239 about?
NCT05725239 is a clinical study titled "taVNS or TMS or Both for Depression". The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) a...
What is the current status of trial NCT05725239?
This trial is currently recruiting. It is a NA study. The enrollment target is 24 participants. The study started on 2023-03-14. Estimated completion is 2026-07-01.
What conditions does trial NCT05725239 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT05725239?
The interventions under investigation include: Transcranial Magnetic Stimulation (DEVICE), Vagus Nerve Stimulation (DEVICE).
Who is sponsoring clinical trial NCT05725239?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05725239 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05725239's enrollment target sits among peer trials
24 594th of 679 higher than 79 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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