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Cystic Fibrosis clinical trials
49 of 170 indexed Cystic Fibrosis trials are currently recruiting.
170 US clinical trials · 49 currently recruiting
Cystic Fibrosis is the subject of 170 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 34 are in Phase 3-4 (later-stage) and 61 in Phase 1-2 (earlier-stage). The most active sponsor is Vertex Pharmaceuticals Incorporated, running 20 of these trials.
The research picture
Cystic Fibrosis has 170 registered US clinical trials, 49 of them open to new participants right now, about 29% of the total.
- 49
- recruiting participants now
- 29%
- of trials open to enrollment
- 34
- in Phase 3–4 (later-stage)
- 20
- top sponsor: Vertex Pharmaceuticals Incorporated
Active & Recent Trials
170 total, page 3 of 4
Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation
Vertex Pharmaceuticals Incorporated
NCT00865904
A Study of the Dosing, Efficacy, and Safety of Oral Cysteamine in Adult Patients With Cystic Fibrosis Exacerbations
NovaBiotics
NCT03000348
Efficacy and Safety Study of AeroVanc for the Treatment of Persistent MRSA Lung Infection in Cystic Fibrosis Patients
Savara
NCT01746095
A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida
University of Miami
NCT02198079
A Study Evaluating the Safety of VX-152 Combination Therapy in Adults With Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
NCT02951195
Behavioral & Nutritional Treatment to Help CF Preschoolers Grow
Children's Hospital Medical Center, Cincinnati
NCT00241969
A Phase 2 Study to Evaluate Efficacy and Safety of VX-561 in Subjects Aged 18 Years and Older With Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
NCT03911713
Interferon Gamma-1b by Inhalation for the Treatment of Patients With Cystic Fibrosis
InterMune
NCT00043316
To Assess the Safety, Tolerability and Pharmacokinetics of AZD5634 Following Inhaled and Intravenous (IV)Dose Administration
AstraZeneca
NCT02679729
Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
Vertex Pharmaceuticals Incorporated
NCT01897233
Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases
Boston Children's Hospital
NCT02831348
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation
Vertex Pharmaceuticals Incorporated
NCT02725567
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
Children's Hospital of Philadelphia
NCT02776098
The Carrier Rates of Pseudomonas Aeruginosa in Family Members of Children With Cystic Fibrosis
Zafer Soultan
NCT01616862
A Decentralized Study to Evaluate Physical Activity and Cough Frequency Using Wearable Technology in Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
NCT04923464
BioEnergetics and Metabolomics in Cystic Fibrosis
Emory University
NCT02225899
Drug-Drug Interaction Study of VX-770 and VX-809 in Healthy Subjects
Vertex Pharmaceuticals Incorporated
NCT01216046
Study to Evaluate Lumacaftor and Ivacaftor Combination Therapy in Subjects 12 Years and Older With Advanced Lung Disease
Vertex Pharmaceuticals Incorporated
NCT02390219
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
Hal C Charles
NCT01710449
Study to Evaluate the Safety & Tolerability of MRT5005 Administered by Nebulization in Adults With Cystic Fibrosis
Sanofi
NCT03375047
19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis
University of North Carolina, Chapel Hill
NCT03489590
Technology-enabled Patient Support System for Self-management of CF
University of Alabama at Birmingham
NCT03910881
Phase II Study of Growth Hormone in Children With Cystic Fibrosis
University of Utah
NCT00016445
Safety, Pharmacokinetic and Pharmacodynamic Study of MP-376 in Patients With Cystic Fibrosis
Amgen
NCT00503490
Safety Study of Inhaled 552-02 in Cystic Fibrosis Patients
Parion Sciences
NCT00274313
A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis
AbbVie
NCT03924947
Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease
National Jewish Health
NCT00659529
Redox Imbalance and the Development of Cystic Fibrosis Diabetes
Emory University
NCT02202876
Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators
University of Alabama at Birmingham
NCT01348204
MAD Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Cavosonstat (N91115) in Healthy Subjects (SNO-9)
Nivalis Therapeutics
NCT02934139
Pilot Trial of Phototherapy for Acute Depression in Hospitalized Cystic Fibrosis Patients
Nationwide Children's Hospital
NCT01822197
Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis
Joseph Zabner
NCT01355796
Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)
Johns Hopkins University
NCT01594827
Energy Balance and Weight Gain With Ivacaftor Treatment
Children's Hospital of Philadelphia
NCT02141464
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
University of North Carolina, Chapel Hill
NCT01615484
A Study to Test How Well BI 1291583 is Tolerated by People With Cystic Fibrosis Bronchiectasis (Clairafly™)
Boehringer Ingelheim
NCT05865886
FDG-PET Imaging in Young Cystic Fibrosis Patients
Washington University School of Medicine
NCT00846053
Absorptive Clearance in the Cystic Fibrosis Airway
University of Pittsburgh
NCT00541190
Feasibility of Home-based Exercise Program for Adults With Cystic Fibrosis
University of Kansas Medical Center
NCT05239611
Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF
Augusta University
NCT03338595
Hydroxychloroquine in Cystic Fibrosis
Vanderbilt University
NCT00311883
Blood Flow and Vascular Function in Cystic Fibrosis
Augusta University
NCT02057458
Effects of Sildenafil on CFTR-dependent Ion Transport Activity
National Jewish Health
NCT01132482
Telavancin Pharmacokinetics in Cystic Fibrosis Patients
Joseph L. Kuti, PharmD
NCT03172793
Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis
Mallinckrodt
NCT00570349
Comparison of Absorption of Vitamin D in Cystic Fibrosis
Emory University
NCT01880346
Comparison of Airway Clearance Therapy in Cystic Fibrosis Using the Same VEST Therapy Device But With Different Settings
University of Minnesota
NCT00685035
Ready to Use Therapeutic Food (RUTF) to Promote Growth in Cystic Fibrosis
Washington University School of Medicine
NCT03462056
Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
University of Vermont
NCT00416182
Pharmacokinetics and Safety Assessment of VX-121/Tezacaftor/Deutivacaftor in Participants With Moderate Hepatic Impairment
Vertex Pharmaceuticals Incorporated
NCT05437120
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 34 |
| Phase 2 | 27 |
| Phase 3 | 19 |
| Phase 4 | 15 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cystic Fibrosis Trial Landscape
170 indexed Cystic Fibrosis studies · 49 recruiting (29%).
Phase mix: 34 late (III/IV) vs 61 early (I/II).
Top sponsor: Vertex Pharmaceuticals Incorporated (20 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cystic Fibrosis?
PlainTrial tracks 170 US clinical trials for Cystic Fibrosis, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cystic Fibrosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.