Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Malignant Solid Neoplasm

Open-data reference.

177 US clinical trials · 94 currently recruiting

Active & Recent Trials

RECRUITING NA 27,500 participants

Identifying and Caring for Individuals With Inherited Cancer Syndrome

OHSU Knight Cancer Institute

NCT04494945

RECRUITING NA 24,000 participants

The Vanguard Study: Testing a New Way to Screen for Cancer

National Cancer Institute (NCI)

NCT06995898

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING 10,000 participants

A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

Mayo Clinic

NCT06192875

RECRUITING 6,150 participants

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

Mayo Clinic

NCT06304168

RECRUITING 5,000 participants

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

National Cancer Institute LAO

NCT02474160

RECRUITING 5,000 participants

Impact of Physician Behavior on Cancer Distress

Mayo Clinic

NCT07325006

RECRUITING 5,000 participants

Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy

M.D. Anderson Cancer Center

NCT00991094

RECRUITING 3,000 participants

Role of Gut Microbiome in Cancer Therapy

Mayo Clinic

NCT05112614

RECRUITING 2,062 participants

Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

SWOG Cancer Research Network

NCT04871542

RECRUITING NA 2,000 participants

A Virtual Community Health Educator for Increasing Clinical Trial Referrals Among Cancer Patients and Their Caregivers

Mayo Clinic

NCT07126496

RECRUITING NA 1,800 participants

Cancer Genetic Testing in Ethnic Populations

Mayo Clinic

NCT04475640

RECRUITING 1,500 participants

Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

University of Washington

NCT01050504

RECRUITING 1,000 participants

Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

Mayo Clinic

NCT06353191

RECRUITING NA 800 participants

Access to Genetic Testing in Underserved Patients With Cancer

University of Southern California

NCT06422455

RECRUITING Phase 3 777 participants

Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy

SWOG Cancer Research Network

NCT05642611

RECRUITING NA 760 participants

Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)

ECOG-ACRIN Cancer Research Group

NCT06295367

RECRUITING Phase 3 668 participants

Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial

University of Rochester

NCT05006482

RECRUITING NA 660 participants

A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors (ASCENT)

Mayo Clinic

NCT06198010

RECRUITING NA 600 participants

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

NRG Oncology

NCT06279013

RECRUITING 600 participants

The Effect of COVID-19 Pandemic on Adolescent and Young Adult Cancer Patients and Survivors

M.D. Anderson Cancer Center

NCT04551378

RECRUITING NA 578 participants

Web-Based Toolkit to Improve Cancer-Related Emotional Distress and Anxiety in Rural Older Cancer Survivors

Northwestern University

NCT07290543

RECRUITING NA 414 participants

Expressive Writing for the Management of Stress in Cancer Survivors

M.D. Anderson Cancer Center

NCT04776941

RECRUITING Phase 3 400 participants

Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment

University of Rochester NCORP Research Base

NCT04829539

RECRUITING NA 400 participants

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

Mayo Clinic

NCT06015932

RECRUITING NA 400 participants

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

Fred Hutchinson Cancer Center

NCT04515810

RECRUITING NA 384 participants

Increasing Knowledge and Interest in Cancer Clinical Trials

Hayley Thompson

NCT06501040

RECRUITING Phase 2 380 participants

Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy

M.D. Anderson Cancer Center

NCT04560673

RECRUITING 350 participants

INTERogating Cancer for Etiology, Prevention and Therapy Navigation

Mayo Clinic

NCT06008392

RECRUITING Phase 1 350 participants

Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

NRG Oncology

NCT03997370

RECRUITING Phase 1 300 participants

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

National Cancer Institute (NCI)

NCT03816345

RECRUITING NA 300 participants

Genetic Testing for the Prevention of Cancer in Indigenous American Communities (JUNIPER Trial)

Mayo Clinic

NCT06569316

RECRUITING NA 300 participants

Evaluating a Mobile Health Application Intervention for Caregiver Instruction in Manual Therapy for Chemotherapy-Induced Peripheral Neuropathy

Mayo Clinic

NCT06945380

RECRUITING 260 participants

Wearable Activity Tracking to Curb Hospitalizations

University of California, San Francis

NCT06587100

RECRUITING NA 256 participants

Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure

M.D. Anderson Cancer Center

NCT02464696

RECRUITING 250 participants

The Impact of COVID-19 on Pulmonary Procedures

M.D. Anderson Cancer Center

NCT05022446

RECRUITING NA 240 participants

Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study

City of Hope Medical Center

NCT05772130

RECRUITING NA 216 participants

Telemedicine for Improvement of Care for Older Adults With Cancer in the Underserved Community, The GAIN-S Trial

City of Hope Medical Center

NCT06022965

RECRUITING NA 208 participants

Outreach Project to Connect Underrepresented Populations to Clinical Trials at Ohio State University, CUSP2CT Project Trial

Ohio State University Comprehensive Cancer Center

NCT06314672

RECRUITING NA 200 participants

Community-Based Physical Activity Intervention for Underserved Cancer Survivors

Roswell Park Cancer Institute

NCT06206863

RECRUITING NA 200 participants

Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)

Ohio State University Comprehensive Cancer Center

NCT05178472

RECRUITING 200 participants

Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

AIDS Malignancy Consortium

NCT05663502

RECRUITING NA 200 participants

Pre-Operative Guided Meditation to Reduce Pre-Operative Anxiety in Patients Undergoing Cancer-Directed Surgery

Ohio State University Comprehensive Cancer Center

NCT06949943

RECRUITING 200 participants

Evaluation of a Novel Auto Segmentation Algorithm for Normal Structure Delineation in Radiation Treatment Planning

Mayo Clinic

NCT06200116

RECRUITING NA 200 participants

Acceptance and Commitment Therapy and Compassion-Based Virtual Group Therapy to Improve Psychological Wellbeing in Patients With Cancer

Mayo Clinic

NCT06246955

RECRUITING Phase 2 190 participants

A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

Children's Oncology Group

NCT06410209

RECRUITING 170 participants

Complications and Clinical Response in Cancer Patients Treated With Anti-VEGF-Related Therapies

M.D. Anderson Cancer Center

NCT05108519

RECRUITING Phase 3 160 participants

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Mayo Clinic

NCT06395441

RECRUITING NA 150 participants

Community-Based Exercise and Nutrition Training and Education Program for Cancer Survivors

Roswell Park Cancer Institute

NCT06565260

RECRUITING NA 147 participants

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Mayo Clinic

NCT06788886

RECRUITING Phase 3 140 participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Mayo Clinic

NCT03750227

RECRUITING 134 participants

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

Mayo Clinic

NCT07477886

RECRUITING NA 125 participants

Communication Issues in Patient and Provider Discussions of Immunotherapy

Emory University

NCT05873608

RECRUITING NA 114 participants

Weighted Blanket Use to Reduce Anxiety in Oncology Patients

Ohio State University Comprehensive Cancer Center

NCT06089408

RECRUITING Phase 3 105 participants

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

Children's Oncology Group

NCT05711667

RECRUITING 100 participants

Investigating Memory and Physical Activity After Cancer Treatment in Survivors of Adolescent and Young Adult Cancers

Mayo Clinic

NCT06880861

RECRUITING 100 participants

Observational Study of Sex Differences in Symptoms During Immune Checkpoint Inhibitor Treatment for People With Cancer

OHSU Knight Cancer Institute

NCT06562777

RECRUITING NA 85 participants

Intravital Microscopy in Human Solid Tumors

Mayo Clinic

NCT03823144

RECRUITING NA 80 participants

A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients

University of Michigan Rogel Cancer Center

NCT07291414

RECRUITING NA 78 participants

Acupressure for the Reduction of Anxiety in Patients Receiving Cancer-Directed Therapy

Mayo Clinic

NCT06723041

RECRUITING NA 76 participants

Transportation for Cancer Care Navigation Tool for Reducing Travel Barriers Among Patients With Solid Tumors Receiving Radiation Therapy

Emory University

NCT06541158

RECRUITING NA 72 participants

CREATE: Art for Children With Cancer

OHSU Knight Cancer Institute

NCT06342453

RECRUITING Phase 1 72 participants

Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines

M.D. Anderson Cancer Center

NCT02962661

RECRUITING Phase 2 70 participants

Cryocompression With or Without Cilostazol for the Prevention of Paclitaxel-induced Neuropathy in Patients With Gynecological Cancers

Emory University

NCT06492070

RECRUITING Phase 1 70 participants

Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia

M.D. Anderson Cancer Center

NCT04565665

RECRUITING Phase 2 70 participants

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

National Cancer Institute (NCI)

NCT06126276

RECRUITING NA 60 participants

Exercise Program (TEAM Me) for the Improvement of Movement and Mobility in Pediatric and Adolescent and Young Adult Patients With Cancer Undergoing a Blood Stem Cell Transplant

M.D. Anderson Cancer Center

NCT04678427

RECRUITING NA 60 participants

Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting

City of Hope Medical Center

NCT07126301

RECRUITING Phase 3 60 participants

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

Children's Oncology Group

NCT06513962

RECRUITING Phase 2 60 participants

Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers

City of Hope Medical Center

NCT05722288

RECRUITING NA 60 participants

Solution-Focused Brief Therapy for Support of Psychological Distress in Adolescent and Young Adult Cancer Survivors

University of Michigan Rogel Cancer Center

NCT06941324

RECRUITING NA 60 participants

Group Curriculum for Improving Survivorship Outcomes in Adolescent and Young Adult Cancer Survivors

Mayo Clinic

NCT05584449

RECRUITING Phase 2 60 participants

Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas

Roswell Park Cancer Institute

NCT06202066

RECRUITING Phase 1 53 participants

Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction

Roswell Park Cancer Institute

NCT06306638

RECRUITING NA 50 participants

Different Types of Massage Therapy to Reduce Anxiety During Chemotherapy Infusion in Patients With Cancer

City of Hope Medical Center

NCT07184294

RECRUITING NA 50 participants

A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment

University of Michigan Rogel Cancer Center

NCT07365007

RECRUITING Early Phase 1 50 participants

L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance

City of Hope Medical Center

NCT07220447

RECRUITING 50 participants

Data-Driven Strategies for Patient Engagement About Cancer Clinical Trials

University of Southern California

NCT07456436

RECRUITING NA 50 participants

Telehealth Intervention for Improving Distress and Financial Toxicity in the Caregivers

Wake Forest University Health Sciences

NCT06709404

RECRUITING NA 44 participants

Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors

City of Hope Medical Center

NCT06500377

RECRUITING 40 participants

Voices: Messages of Wisdom and Hope in the Face of Illness

Mayo Clinic

NCT07381179

RECRUITING 38 participants

Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy

Masonic Cancer Center, University of Minnesota

NCT06414278

RECRUITING Phase 2 32 participants

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

City of Hope Medical Center

NCT05830058

RECRUITING NA 30 participants

Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care

University of California, San Francis

NCT05641961

RECRUITING Phase 1 30 participants

Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients

M.D. Anderson Cancer Center

NCT05101213

RECRUITING NA 30 participants

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

Mayo Clinic

NCT07291011

RECRUITING Early Phase 1 30 participants

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

M.D. Anderson Cancer Center

NCT06184321

RECRUITING 30 participants

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Mayo Clinic

NCT06640010

RECRUITING NA 28 participants

Virtual Reality for Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation

Roswell Park Cancer Institute

NCT06798701

RECRUITING 24 participants

Ex Vivo Expansion (ACT-X)

Mayo Clinic

NCT07137312

RECRUITING NA 24 participants

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Mayo Clinic

NCT07221409

RECRUITING NA 20 participants

Virtual Art Therapy Assisted Re-Integration to Improve Biopsychosocial Outcomes in Adolescent and Young Adult Cancer Survivors, AVATARS Trial

Mayo Clinic

NCT07089927

RECRUITING 20 participants

Assessing Effect of Spinal Cord Stimulation on Pain and Quality of Life With Chemotherapy-Induced Peripheral Neuropathy

Mayo Clinic

NCT05411523

RECRUITING 10 participants

Formulating Expert Consensus Guidelines in Cancer Care Using the Delphi Method

M.D. Anderson Cancer Center

NCT05054413

ACTIVE NOT RECRUITING 13,378 participants

Well-Being and Health-Related Quality of Life in Cancer Patients and Survivors During the COVID-19 Pandemic

M.D. Anderson Cancer Center

NCT04500600

ACTIVE NOT RECRUITING 2,100 participants

An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study

University of Rochester NCORP Research Base

NCT05364086

ACTIVE NOT RECRUITING 1,877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

National Cancer Institute (NCI)

NCT04387656

ACTIVE NOT RECRUITING 1,242 participants

Impact of the COVID-19 Pandemic and HRQOL in Cancer Patients and Survivors

M.D. Anderson Cancer Center

NCT04447222

ACTIVE NOT RECRUITING 625 participants

Financial Toxicity in Cancer Patients

M.D. Anderson Cancer Center

NCT04592250

ACTIVE NOT RECRUITING NA 600 participants

Yoga Program for Improving the Quality of Life in Couples Coping With Cancer

M.D. Anderson Cancer Center

NCT04607590

Phase Distribution

PhaseTrial count
Early Phase 1 24
Phase 2 22
Phase 3 12
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Solid Neoplasm Trial Landscape

ClinicalTrials.gov lists 177 US studies indexed under Malignant Solid Neoplasm, and 94 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Malignant Solid Neoplasm shows 14 late-stage studies (Phase 3 and Phase 4 combined) alongside 46 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Malignant Solid Neoplasm is led by M.D. Anderson Cancer Center with 42 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Solid Neoplasm?

PlainTrial tracks 177 US clinical trials for Malignant Solid Neoplasm, of which 94 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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