Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Traumatic Brain Injury: early-phase trial registry
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #63 of 28,707 conditions by registered trial count.
172 US clinical trials · 75 currently recruiting · #63 of 28,707 conditions by registered trial count
Traumatic Brain Injury: 172 US clinical trials tracked, 75 recruiting.
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
Enrollment posture brief
Registry condition traumatic-brain-injury
OPEN 75 | RECR 44% | LATE 5 | EARLY 23 | RANK #63 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Binge-Eating Disorder (44% recruiting · 39 trials)
Traumatic Brain Injury lists 75 open slots (44% of 172 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Traumatic Brain Injury on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Traumatic Brain Injury is recruiting above its size-band peers.
75 of 172 indexed trials (43.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Traumatic Brain Injury trials is spread across many organizations.
VA Office of Research and Development accounts for 11 of 172 trials (6.4%). 95 distinct sponsors appear on at least one study for this condition label.
-
Typical Traumatic Brain Injury enrolment sits around 80 participants.
Median target enrolment is 80 among the 172 trials that report a genuine target (sentinel values excluded). 99 of those (57.6%) plan for fewer than 100 participants.
-
Traumatic Brain Injury research is mostly interventional.
122 interventional and 50 observational studies make up this index (70.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
172 total, page 1 of 4
Evaluation of the SCALED (SCaling AcceptabLE cDs)
University of Minnesota
NCT05628207
Phase I Human Analytics (HALO) Study
HALO Diagnostics
NCT05423860
A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury
Hoffmann-La Roche
NCT07455136
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury
University of Maryland, Baltimore
NCT05084352
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
Wake Forest University Health Sciences
NCT06866691
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
CoMind Early Feasibility Study
CoMind Technologies Limited
NCT06368648
Neurologic Stem Cell Treatment Study
MD Stem Cells
NCT02795052
Evaluation of the Abbott i-STAT TBI Biomarker Test
Icahn School of Medicine at Mount Sinai
NCT06766435
Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury
University of South Florida
NCT06581003
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Johns Hopkins University
NCT05663034
The EBC Recovery Study
University of Miami
NCT04712591
University of Pittsburgh Brain Health Initiative
David Okonkwo, MD, PhD
NCT04708613
Cognitive and Vascular Functioning Following TBI
Walter Reed National Military Medical Center
NCT06034509
Pilot Study of BCAA on Sleep
Portland VA Medical Center
NCT03990909
Traumatic Brain Injury and Stroke Long Term Outcome
Centre for Neuro Skills
NCT03399929
Non-invasive Nerve Stimulation for PTSD and Sleep
University of Florida
NCT03170440
Carbon Dioxide Administration and Brain Waste Clearance
Andrew Mayer
NCT07357090
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
Children's Hospital Medical Center, Cincinnati
NCT05622461
Hyperbaric Oxygen Brain Injury Treatment Trial
Gaylan Rockswold
NCT02407028
Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics
Wake Forest University Health Sciences
NCT06697808
The REACH Intervention for Caregivers of Veterans and Service Members With TBI
University of Virginia
NCT06111794
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
University of Pittsburgh
NCT02592291
Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures
University of Michigan
NCT07225101
Sildenafil for Microvasculopathy in Chronic TBI
University of Pennsylvania
NCT05782244
A Study to Evaluate the SENSE Device's Ability to Detect TBI
Sense Diagnostics
NCT06828107
Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.
NYU Langone Health
NCT04349852
The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
University of Michigan
NCT04855396
MENTOR Wellness Program
NYU Langone Health
NCT06148324
Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation
The University of Texas at Dallas
NCT04869059
Personalized Cognitive Integrated Motor Training Using Virtual Reality to Improve Gait and Balance
Kessler Foundation
NCT06473987
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Florida State University
NCT06544408
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Virginia Commonwealth University
NCT06188364
Predict Severe Traumatic Brain Injury
University of Chicago
NCT06966713
TBI Rehabilitation and Activation in Veterans
Northern California Institute of Research and Education
NCT06562127
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Randy Kardon
NCT03694626
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
NYU Langone Health
NCT04550377
High Intensity Step Training After Traumatic Brain Injury
Craig Hospital
NCT05702138
Longitudinal Assessment of Traumatic Microvascular Injury-2
University of Pennsylvania
NCT05725993
Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
University of New Mexi
NCT05236010
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
New Jersey Institute of Technology
NCT06105892
Non-invasive BCI-controlled Assistive Devices
University of Texas at Austin
NCT05183152
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
University of Arizona
NCT06282965
University of Colorado - Restoring Efficient Sleep After TBI
VA Eastern Colorado Health Care System
NCT05683145
Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series
Reset Medical and Wellness Center
NCT07473505
Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
University of Cincinnati
NCT05337618
tPBM in Older Adults With Traumatic Brain Injury
NYU Langone Health
NCT06956404
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Traumatic Brain Injury records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Traumatic Brain Injury trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Traumatic Brain Injury page
172 registered trials, 75 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 75 Traumatic Brain Injury trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Traumatic Brain Injury trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Traumatic Brain Injury condition card totals 172 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.