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Traumatic Brain Injury clinical trials
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.
172 US clinical trials · 75 currently recruiting
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
The research picture
Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.
- 75
- recruiting participants now
- 44%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 11
- top sponsor: VA Office of Research and Development
Active & Recent Trials
172 total, page 1 of 4
Evaluation of the SCALED (SCaling AcceptabLE cDs)
University of Minnesota
NCT05628207
Phase I Human Analytics (HALO) Study
HALO Diagnostics
NCT05423860
A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury
Hoffmann-La Roche
NCT07455136
Retinal Imaging in Neurodegenerative Disease
Duke University
NCT03233646
Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury
University of Maryland, Baltimore
NCT05084352
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
Wake Forest University Health Sciences
NCT06866691
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
CoMind Early Feasibility Study
CoMind Technologies Limited
NCT06368648
Neurologic Stem Cell Treatment Study
MD Stem Cells
NCT02795052
Evaluation of the Abbott i-STAT TBI Biomarker Test
Icahn School of Medicine at Mount Sinai
NCT06766435
Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury
University of South Florida
NCT06581003
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Johns Hopkins University
NCT05663034
The EBC Recovery Study
University of Miami
NCT04712591
University of Pittsburgh Brain Health Initiative
David Okonkwo, MD, PhD
NCT04708613
Cognitive and Vascular Functioning Following TBI
Walter Reed National Military Medical Center
NCT06034509
Pilot Study of BCAA on Sleep
Portland VA Medical Center
NCT03990909
Traumatic Brain Injury and Stroke Long Term Outcome
Centre for Neuro Skills
NCT03399929
Non-invasive Nerve Stimulation for PTSD and Sleep
University of Florida
NCT03170440
Carbon Dioxide Administration and Brain Waste Clearance
Andrew Mayer
NCT07357090
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
Children's Hospital Medical Center, Cincinnati
NCT05622461
Hyperbaric Oxygen Brain Injury Treatment Trial
Gaylan Rockswold
NCT02407028
Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics
Wake Forest University Health Sciences
NCT06697808
The REACH Intervention for Caregivers of Veterans and Service Members With TBI
University of Virginia
NCT06111794
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
University of Pittsburgh
NCT02592291
Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures
University of Michigan
NCT07225101
Sildenafil for Microvasculopathy in Chronic TBI
University of Pennsylvania
NCT05782244
A Study to Evaluate the SENSE Device's Ability to Detect TBI
Sense Diagnostics
NCT06828107
Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.
NYU Langone Health
NCT04349852
The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
University of Michigan
NCT04855396
MENTOR Wellness Program
NYU Langone Health
NCT06148324
Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation
The University of Texas at Dallas
NCT04869059
Personalized Cognitive Integrated Motor Training Using Virtual Reality to Improve Gait and Balance
Kessler Foundation
NCT06473987
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Florida State University
NCT06544408
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Virginia Commonwealth University
NCT06188364
Predict Severe Traumatic Brain Injury
University of Chicago
NCT06966713
TBI Rehabilitation and Activation in Veterans
Northern California Institute of Research and Education
NCT06562127
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Randy Kardon
NCT03694626
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
NYU Langone Health
NCT04550377
High Intensity Step Training After Traumatic Brain Injury
Craig Hospital
NCT05702138
Longitudinal Assessment of Traumatic Microvascular Injury-2
University of Pennsylvania
NCT05725993
Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
University of New Mexi
NCT05236010
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
New Jersey Institute of Technology
NCT06105892
Non-invasive BCI-controlled Assistive Devices
University of Texas at Austin
NCT05183152
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
University of Arizona
NCT06282965
University of Colorado - Restoring Efficient Sleep After TBI
VA Eastern Colorado Health Care System
NCT05683145
Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series
Reset Medical and Wellness Center
NCT07473505
Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
University of Cincinnati
NCT05337618
tPBM in Older Adults With Traumatic Brain Injury
NYU Langone Health
NCT06956404
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Traumatic Brain Injury Trial Landscape
172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).
Phase mix: 5 late (III/IV) vs 23 early (I/II).
Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Traumatic Brain Injury?
PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Traumatic Brain Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.