Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Prostatic Neoplasms

Open-data reference.

66 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING 3,000 participants

Prostate Active Surveillance Study

University of Washington

NCT00756665

RECRUITING Phase 3 1,440 participants

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

Merck Sharp & Dohme

NCT06925737

RECRUITING 1,400 participants

A Study to Learn About Real-world Utilization and Outcomes of Darolutamide and Other Androgen Receptor Pathway Inhibitors (ARPIs) for Newly Diagnosed Metastatic Hormone-sensitive Prostate Cancer (de Novo mHSPC) in US Urology Clinics

Bayer

NCT07406282

RECRUITING Phase 3 1,314 participants

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Merck Sharp & Dohme

NCT06136650

RECRUITING 1,000 participants

Collection of Blood From Patients With Prostate Cancer

National Cancer Institute (NCI)

NCT00923221

RECRUITING 500 participants

Men at High Genetic Risk for Prostate Cancer

National Cancer Institute (NCI)

NCT03805919

RECRUITING Phase 3 383 participants

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

Clarity Pharmaceuticals

NCT06056830

RECRUITING 300 participants

Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy

National Cancer Institute (NCI)

NCT01834001

RECRUITING Phase 1 252 participants

Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617

Pathos AI

NCT06785636

RECRUITING Phase 1 160 participants

A Study of DM002 in Patients With Advanced Solid Tumors

Xadcera Biopharmaceutical (Suzhou) Co.

NCT06751329

RECRUITING Phase 1 140 participants

A Study of JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer

Janssen Research & Development

NCT07082920

RECRUITING Phase 2 120 participants

Diagnostic Utility of rhPSMA-7.3 (18F) PET/CT in Men With Prostate Cancer on Active Surveillance

Icahn School of Medicine at Mount Sinai

NCT07285057

RECRUITING Phase 2 110 participants

RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

Dana-Farber Cancer Institute

NCT05765500

RECRUITING Phase 1 82 participants

Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

Blue Earth Therapeutics

NCT05413850

RECRUITING Phase 2 42 participants

Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

National Cancer Institute (NCI)

NCT05616650

RECRUITING Phase 1 40 participants

A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer

Janssen Research & Development

NCT07319871

RECRUITING Phase 1 25 participants

HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

The Methodist Hospital Research Institute

NCT01913106

RECRUITING NA 24 participants

Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With Acupuncture

Inova Health Care Services

NCT07335224

RECRUITING Phase 4 15 participants

18F-Fluciclovine PET/CT Impact on Predicting Clinical Outcome of 177Lu-PSMA-617 Therapy in Patients With Prostate Cancer

VA Greater Los Angeles Healthcare System

NCT06706921

ACTIVE NOT RECRUITING Phase 3 2,517 participants

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

Janssen Research & Development

NCT03767244

ACTIVE NOT RECRUITING Phase 3 1,503 participants

An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS

Aragon Pharmaceuticals

NCT02531516

ACTIVE NOT RECRUITING Phase 3 1,244 participants

Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

Merck Sharp & Dohme

NCT03834493

ACTIVE NOT RECRUITING Phase 3 1,207 participants

A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer

Aragon Pharmaceuticals

NCT01946204

ACTIVE NOT RECRUITING Phase 3 1,145 participants

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)

Novartis Pharmaceuticals

NCT04720157

ACTIVE NOT RECRUITING Phase 3 1,125 participants

Enzalutamide in First Line Androgen Deprivation Therapy for Metastatic Prostate Cancer

University of Sydney

NCT02446405

ACTIVE NOT RECRUITING 992 participants

Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Memorial Sloan Kettering Cancer Center

NCT00579163

ACTIVE NOT RECRUITING Phase 3 982 participants

An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)

Aragon Pharmaceuticals

NCT02257736

ACTIVE NOT RECRUITING Phase 3 925 participants

A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Eli Lilly and Company

NCT05288166

ACTIVE NOT RECRUITING Phase 3 802 participants

Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer

University of Sydney

NCT02446444

ACTIVE NOT RECRUITING Phase 3 693 participants

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Janssen Pharmaceutica N.V., Belgium

NCT04557059

ACTIVE NOT RECRUITING Phase 3 469 participants

177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer

Novartis Pharmaceuticals

NCT04689828

ACTIVE NOT RECRUITING Phase 1 216 participants

A Study of JNJ-78278343, a T-Cell-Redirecting Agent Targeting Human Kallikrein 2 (KLK2), for Advanced Prostate Cancer

Janssen Research & Development

NCT04898634

ACTIVE NOT RECRUITING Phase 1 144 participants

A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer

Janssen Research & Development

NCT04644770

ACTIVE NOT RECRUITING Phase 1 136 participants

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Janssen Research & Development

NCT04577833

ACTIVE NOT RECRUITING Phase 2 129 participants

18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer

Columbia University

NCT03824275

ACTIVE NOT RECRUITING 118 participants

Evaluation of Atherosclerotic Plaques in Abdominal CT Studies

National Institutes of Health Clinical Center (CC)

NCT04652973

ACTIVE NOT RECRUITING Phase 2 109 participants

A Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects With Advanced Solid Tumors and Subsequent Dose Expansion Cohorts

Promontory Therapeutics

NCT02266745

ACTIVE NOT RECRUITING Phase 2 96 participants

18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT03173924

ACTIVE NOT RECRUITING NA 68 participants

Exercise for Tumor Suppressive Impact in Black Men With Prostate Cancer on Active Surveillance: The REMOVE Trial

Dana-Farber Cancer Institute

NCT05918263

ACTIVE NOT RECRUITING Phase 1 57 participants

A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer

Aragon Pharmaceuticals

NCT02123758

ACTIVE NOT RECRUITING Phase 1 15 participants

A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants

Janssen Research & Development

NCT05022849

COMPLETED Phase 3 1,224 participants

Aflibercept in Combination With Docetaxel in Metastatic Androgen Independent Prostate Cancer

Sanofi

NCT00519285

COMPLETED Phase 3 1,195 participants

Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy

Cougar Biotechnology

NCT00638690

COMPLETED Phase 3 1,030 participants

Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)

Merck Sharp & Dohme

NCT03834506

COMPLETED Phase 3 1,028 participants

Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100

Exelixis

NCT01605227

COMPLETED Phase 3 806 participants

Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms

Bayer

NCT02043678

COMPLETED Phase 3 793 participants

Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010)

Merck Sharp & Dohme

NCT03834519

COMPLETED Phase 3 755 participants

XRP6258 Plus Prednisone Compared to Mitoxantrone Plus Prednisone in Hormone Refractory Metastatic Prostate Cancer

Sanofi

NCT00417079

COMPLETED 714 participants

Retrospective Observational Study Investigating Fluciclovine (18F) (FACBC)

Blue Earth Diagnostics

NCT02443571

COMPLETED NA 307 participants

CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR Brachytherapy Dosimetry

Accuray Incorporated

NCT00643617

COMPLETED Early Phase 1 116 participants

18F-DCFBC PET/CT in Prostate Cancer

National Cancer Institute (NCI)

NCT02190279

COMPLETED 71 participants

Prostate Mechanical Imager (PMI) Clinical Bridging Study

Artann Laboratories

NCT00822952

COMPLETED Phase 2 68 participants

A Randomized Phase IIa Efficacy and Safety Study of Radium-223 Dichloride With Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (CRPC)

Bayer

NCT02034552

COMPLETED Phase 2 48 participants

EPO906 Therapy in Patients With Prostate Cancer

Novartis Pharmaceuticals

NCT00035113

COMPLETED Early Phase 1 39 participants

Gallium-68 Citrate PET Used in Prostate Cancer

Rahul Aggarwal

NCT02391025

COMPLETED Phase 1 34 participants

A Safety and Pharmacokinetics Study of Niraparib Plus an Androgen Receptor-Targeted Therapy in Men With Metastatic Castration-Resistant Prostate Cancer (BEDIVERE)

Janssen Research & Development

NCT02924766

COMPLETED Phase 1 25 participants

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer

Pharmacyclics

NCT00120939

COMPLETED Phase 2 23 participants

Pembrolizumab +/- SD-101 in Hormone-Naïve Oligometastatic Prostate Cancer With RT and iADT

David Oh

NCT03007732

COMPLETED Phase 2 22 participants

A Phase IIa. Open-label, Multicenter, Dose-escalation Study to Assess the Tolerability and Pharmacokinetics of ZD4054 (Zibotentan) Given Orally Once Daily in Subjects With Metastatic Prostate Cancer

AstraZeneca

NCT00055471

COMPLETED Early Phase 1 22 participants

Biodistribution/Reproducibility Ga-68 PSMA-HBED-CC

University of Iowa

NCT02952469

COMPLETED Phase 2 21 participants

Targeted Fusion Biopsy of the Prostate

Emory University

NCT02744534

COMPLETED Phase 2 19 participants

A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer

Infinity Pharmaceuticals

NCT00564928

COMPLETED Phase 1 18 participants

Evaluation of Transgenic Lymphocyte Immunization Vaccine in Subjects With Prostate Adenocarcinoma

Cosmo Bioscience

NCT00061035

COMPLETED Phase 1 10 participants

Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment

Eli Lilly and Company

NCT05999968

COMPLETED Phase 2 2 participants

Continuation Trial Evaluating the Tolerability and Activity of FK228 in Patients That Completed Prior Study With FK228

Celgene

NCT00106301

COMPLETED Phase 2 1 participants

G-202 in the Neoadjuvant Setting Followed by Radical Prostatectomy in Patients With Prostate Cancer

GenSpera

NCT02381236

Phase Distribution

PhaseTrial count
Early Phase 1 18
Phase 2 14
Phase 3 21
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Prostatic Neoplasms Trial Landscape

ClinicalTrials.gov lists 66 US studies indexed under Prostatic Neoplasms, and 19 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Prostatic Neoplasms shows 22 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Prostatic Neoplasms is led by Janssen Research & Development with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 66 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Prostatic Neoplasms?

PlainTrial tracks 66 US clinical trials for Prostatic Neoplasms, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Prostatic Neoplasms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →