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NCT00541190 · ClinicalTrials.gov registry record · NA
Absorptive Clearance in the Cystic Fibrosis Airway
A NA study of Cystic Fibrosis, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT00541190 is a NA study of Cystic Fibrosis that has completed, run by University of Pittsburgh. The registered enrollment target is 21 participants, below the 179-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00541190, a NA study of Cystic Fibrosis, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this overall project is to develop a new aerosol-based technique for quantifying liquid absorption in the airways of subjects with cystic fibrosis(CF) that can be used to help develop new therapies. In CF, mutations in the CF gene result in dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ion channel on the cells that line the airway epithelium, causing improper fluxes of ions such as sodium, chloride, and bicarbonate. The so called "low volume" hypothesis of CF pathogenesis contends that abnormal absorption of ions from the airways causes excessive absorption of liquid, resulting in an airway surface liquid layer that is dehydrated and difficult to clear. Here we are measuring the absorption rate of a radiolabeled small molecule (DTPA) from the lungs of cystic fibrosis patients and healthy controls. We hypothesize that the molecule will absorb more quickly in cystic fibrosis patients. Further studies will be performed to determine if DTPA absorption is related to liquid absorption in the airways.
Conditions Studied
Interventions
- OTHER Technetium [Tc-99m] sulfur colloid and Indium [In-111] DTPA
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2007-10 |
| Est. Completion | 2008-04 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00541190
The ClinicalTrials.gov registry entry for NCT00541190 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 179-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (88% lower). The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Cystic Fibrosis appearing as the primary indexed condition, and to 1 intervention - of which Technetium [Tc-99m] sulfur colloid and Indium [In-111] DTPA is the first listed.
NCT00541190 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT00541190 about?
NCT00541190 is a clinical study titled "Absorptive Clearance in the Cystic Fibrosis Airway". The objective of this overall project is to develop a new aerosol-based technique for quantifying liquid absorption in the airways of subjects with cystic fibrosis(CF) that can be used to help develop new therapies. In CF, mutations in the CF gene result in dysfunction of the Cystic Fibrosis Transme...
What is the current status of trial NCT00541190?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2007-10. Estimated completion is 2008-04.
What conditions does trial NCT00541190 study?
This clinical trial studies the following conditions: Cystic Fibrosis.
What interventions are being tested in trial NCT00541190?
The interventions under investigation include: Technetium [Tc-99m] sulfur colloid and Indium [In-111] DTPA (OTHER).
Who is sponsoring clinical trial NCT00541190?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00541190 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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