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Cystic Fibrosis: early-phase trial registry
49 of 170 indexed Cystic Fibrosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #64 of 28,707 conditions by registered trial count.
170 US clinical trials · 49 currently recruiting · #64 of 28,707 conditions by registered trial count
Cystic Fibrosis: 170 US clinical trials tracked, 49 recruiting.
Cystic Fibrosis is the subject of 170 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 34 are in Phase 3-4 (later-stage) and 61 in Phase 1-2 (earlier-stage). The most active sponsor is Vertex Pharmaceuticals Incorporated, running 20 of these trials.
Enrollment posture brief
Registry condition cystic-fibrosis
OPEN 49 | RECR 29% | LATE 34 | EARLY 61 | RANK #64 | SPON 20
Volume-matched condition peers
Nearest open-share peer: Prostatic Neoplasms (29% recruiting · 66 trials)
Cystic Fibrosis lists 49 open slots (29% of 170 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cystic Fibrosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cystic Fibrosis is recruiting below its size-band peers.
49 of 170 indexed trials (28.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cystic Fibrosis trials is spread across many organizations.
Vertex Pharmaceuticals Incorporated accounts for 20 of 170 trials (11.8%). 84 distinct sponsors appear on at least one study for this condition label.
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Most Cystic Fibrosis trials plan to enrol fewer than 100 people.
Median target enrolment is 59 among the 170 trials that report a genuine target (sentinel values excluded). 107 of those (62.9%) plan for fewer than 100 participants.
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Cystic Fibrosis research is mostly interventional.
121 interventional and 49 observational studies make up this index (71.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
170 total, page 4 of 4
Effect of Lucinactant on Mucus Clearance in Cystic Fibrosis Lung Disease
University of North Carolina, Chapel Hill
NCT00934362
PR-018: An Open-Label, Safety Extension of Study PR-011
Forest Laboratories
NCT01131507
SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis
Anthera Pharmaceuticals
NCT02734810
Exercise-Induced Bronchospasm in Cystic Fibrosis
Ohio State University
NCT00806455
IL-17 Neutrophils in CF Lung Inflammation
University Hospitals Cleveland Medical Center
NCT02025829
The Impact of Patch Rx Technologies on Adherence to Vitamin and Trikafta Therapies in Patients With Cystic Fibrosis
The University of Texas Health Science Center at San Antonio
NCT04684823
Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis
Joseph Pilewski
NCT03391414
Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis
University of Southern California
NCT02444234
A Pilot Study of a Low Glycemic Load Diet in Adults With Cystic Fibrosis
Boston Children's Hospital
NCT04519853
Safety Study of Orally Administered Curcuminoids in Adult Subjects With Cystic Fibrosis
Ramsey, Bonnie, MD
NCT00219882
Clearance of 25-hydroxyvitamin D in Cystic Fibrosis
University of Washington
NCT03104855
Flaxseed Modulates Inflammation and Oxidative Stress in CF
University of Pennsylvania
NCT02014181
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QAU145 in Patients With Cystic Fibrosis
Novartis Pharmaceuticals
NCT00506792
Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea
Children's Hospital of Philadelphia
NCT00572975
SD Cystic Fibrosis Study
GlaxoSmithKline
NCT00605761
Clinical Outcomes of Triple Combination Therapy in Severe Cystic Fibrosis Disease.
National Jewish Health
NCT04038710
Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis
Children's Hospital Medical Center, Cincinnati
NCT03771313
PK Study of N91115 in Cystic Fibrosis Patients
Nivalis Therapeutics
NCT02227888
Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis
Nemours Children's Clinic
NCT01721382
Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations
University of Alabama at Birmingham
NCT03256799
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 34 |
| Phase 2 | 27 |
| Phase 3 | 19 |
| Phase 4 | 15 |
Top Sponsors
Named interventions
Most-linked intervention names on Cystic Fibrosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cystic Fibrosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cystic Fibrosis page
170 registered trials, 49 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 49 Cystic Fibrosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vertex Pharmaceuticals Incorporated sponsors the most Cystic Fibrosis trials on record, review their full trial history before evaluating a specific study. See Vertex Pharmaceuticals Incorporated's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cystic Fibrosis condition card totals 170 registered trials; most-linked intervention Placebo; top US site state Colorado. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.