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Cystic Fibrosis clinical trials
49 of 170 indexed Cystic Fibrosis trials are currently recruiting.
170 US clinical trials · 49 currently recruiting
Cystic Fibrosis is the subject of 170 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 34 are in Phase 3-4 (later-stage) and 61 in Phase 1-2 (earlier-stage). The most active sponsor is Vertex Pharmaceuticals Incorporated, running 20 of these trials.
The research picture
Cystic Fibrosis has 170 registered US clinical trials, 49 of them open to new participants right now, about 29% of the total.
- 49
- recruiting participants now
- 29%
- of trials open to enrollment
- 34
- in Phase 3–4 (later-stage)
- 20
- top sponsor: Vertex Pharmaceuticals Incorporated
Active & Recent Trials
170 total, page 4 of 4
Effect of Lucinactant on Mucus Clearance in Cystic Fibrosis Lung Disease
University of North Carolina, Chapel Hill
NCT00934362
PR-018: An Open-Label, Safety Extension of Study PR-011
Forest Laboratories
NCT01131507
SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis
Anthera Pharmaceuticals
NCT02734810
Exercise-Induced Bronchospasm in Cystic Fibrosis
Ohio State University
NCT00806455
IL-17 Neutrophils in CF Lung Inflammation
University Hospitals Cleveland Medical Center
NCT02025829
The Impact of Patch Rx Technologies on Adherence to Vitamin and Trikafta Therapies in Patients With Cystic Fibrosis
The University of Texas Health Science Center at San Antonio
NCT04684823
Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis
Joseph Pilewski
NCT03391414
Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis
University of Southern California
NCT02444234
A Pilot Study of a Low Glycemic Load Diet in Adults With Cystic Fibrosis
Boston Children's Hospital
NCT04519853
Safety Study of Orally Administered Curcuminoids in Adult Subjects With Cystic Fibrosis
Ramsey, Bonnie, MD
NCT00219882
Clearance of 25-hydroxyvitamin D in Cystic Fibrosis
University of Washington
NCT03104855
Flaxseed Modulates Inflammation and Oxidative Stress in CF
University of Pennsylvania
NCT02014181
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QAU145 in Patients With Cystic Fibrosis
Novartis Pharmaceuticals
NCT00506792
Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea
Children's Hospital of Philadelphia
NCT00572975
SD Cystic Fibrosis Study
GlaxoSmithKline
NCT00605761
Clinical Outcomes of Triple Combination Therapy in Severe Cystic Fibrosis Disease.
National Jewish Health
NCT04038710
Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis
Children's Hospital Medical Center, Cincinnati
NCT03771313
PK Study of N91115 in Cystic Fibrosis Patients
Nivalis Therapeutics
NCT02227888
Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis
Nemours Children's Clinic
NCT01721382
Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations
University of Alabama at Birmingham
NCT03256799
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 34 |
| Phase 2 | 27 |
| Phase 3 | 19 |
| Phase 4 | 15 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cystic Fibrosis Trial Landscape
170 indexed Cystic Fibrosis studies · 49 recruiting (29%).
Phase mix: 34 late (III/IV) vs 61 early (I/II).
Top sponsor: Vertex Pharmaceuticals Incorporated (20 trials), 9 others listed. 20 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cystic Fibrosis?
PlainTrial tracks 170 US clinical trials for Cystic Fibrosis, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cystic Fibrosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.