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ClinicalTrials.gov 49 recruiting now official registry

Cystic Fibrosis clinical trials

49 of 170 indexed Cystic Fibrosis trials are currently recruiting.

170 US clinical trials · 49 currently recruiting

Cystic Fibrosis is the subject of 170 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 34 are in Phase 3-4 (later-stage) and 61 in Phase 1-2 (earlier-stage). The most active sponsor is Vertex Pharmaceuticals Incorporated, running 20 of these trials.

The research picture

Cystic Fibrosis has 170 registered US clinical trials, 49 of them open to new participants right now, about 29% of the total.

49
recruiting participants now
29%
of trials open to enrollment
34
in Phase 3–4 (later-stage)
20
top sponsor: Vertex Pharmaceuticals Incorporated
Phase 134Phase 227Phase 319Phase 415

Active & Recent Trials

170 total, page 4 of 4

COMPLETED Phase 2 16 participants

Effect of Lucinactant on Mucus Clearance in Cystic Fibrosis Lung Disease

University of North Carolina, Chapel Hill

NCT00934362

COMPLETED Phase 4 15 participants

PR-018: An Open-Label, Safety Extension of Study PR-011

Forest Laboratories

NCT01131507

COMPLETED Phase 3 15 participants

SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis

Anthera Pharmaceuticals

NCT02734810

COMPLETED 14 participants

Exercise-Induced Bronchospasm in Cystic Fibrosis

Ohio State University

NCT00806455

COMPLETED 14 participants

IL-17 Neutrophils in CF Lung Inflammation

University Hospitals Cleveland Medical Center

NCT02025829

COMPLETED NA 12 participants

The Impact of Patch Rx Technologies on Adherence to Vitamin and Trikafta Therapies in Patients With Cystic Fibrosis

The University of Texas Health Science Center at San Antonio

NCT04684823

COMPLETED Phase 1 12 participants

Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis

Joseph Pilewski

NCT03391414

COMPLETED Phase 4 11 participants

Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis

University of Southern California

NCT02444234

COMPLETED NA 11 participants

A Pilot Study of a Low Glycemic Load Diet in Adults With Cystic Fibrosis

Boston Children's Hospital

NCT04519853

COMPLETED Phase 1 11 participants

Safety Study of Orally Administered Curcuminoids in Adult Subjects With Cystic Fibrosis

Ramsey, Bonnie, MD

NCT00219882

COMPLETED Phase 1 10 participants

Clearance of 25-hydroxyvitamin D in Cystic Fibrosis

University of Washington

NCT03104855

COMPLETED Phase 1 10 participants

Flaxseed Modulates Inflammation and Oxidative Stress in CF

University of Pennsylvania

NCT02014181

COMPLETED Phase 2 9 participants

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QAU145 in Patients With Cystic Fibrosis

Novartis Pharmaceuticals

NCT00506792

COMPLETED Phase 4 9 participants

Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea

Children's Hospital of Philadelphia

NCT00572975

COMPLETED Phase 1 9 participants

SD Cystic Fibrosis Study

GlaxoSmithKline

NCT00605761

COMPLETED 8 participants

Clinical Outcomes of Triple Combination Therapy in Severe Cystic Fibrosis Disease.

National Jewish Health

NCT04038710

COMPLETED Phase 4 8 participants

Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis

Children's Hospital Medical Center, Cincinnati

NCT03771313

COMPLETED Phase 1 6 participants

PK Study of N91115 in Cystic Fibrosis Patients

Nivalis Therapeutics

NCT02227888

COMPLETED Phase 1 6 participants

Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis

Nemours Children's Clinic

NCT01721382

COMPLETED Phase 4 1 participants

Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations

University of Alabama at Birmingham

NCT03256799

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Phase Distribution

PhaseTrial count
Phase 1 34
Phase 2 27
Phase 3 19
Phase 4 15

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cystic Fibrosis Trial Landscape

170 indexed Cystic Fibrosis studies · 49 recruiting (29%).

Phase mix: 34 late (III/IV) vs 61 early (I/II).

Top sponsor: Vertex Pharmaceuticals Incorporated (20 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cystic Fibrosis?

PlainTrial tracks 170 US clinical trials for Cystic Fibrosis, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cystic Fibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.