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NCT03489590 · ClinicalTrials.gov registry record · Early Phase 1
19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis
A Early Phase 1 study of Cystic Fibrosis, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT03489590: Completed Early Phase 1 study of Cystic Fibrosis, sponsored by University of North Carolina, Chapel Hill.
NCT03489590 is a Early Phase 1 study of Cystic Fibrosis that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 42 participants, below the 179-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (77% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03489590, a Early Phase 1 study of Cystic Fibrosis, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
An open label non-randomized study enrolling up to 20 healthy participants and up to 30 participants with cystic fibrosis to establish a healthy versus disease comparison. Each participant will receive a mixture of inert gas (perfluoropropane (PFP)) in a ratio of 79% PFP to 21% oxygen as a contrast agent to enhance visualization of the airway and alveolar spaces using magnetic resonance imaging of inert gas/oxygen mixtures. The study consists of a screening visit followed by up to 2 study visits.
Primary Outcome
Determine if 19F gas images of the human lung and airways can be obtained in both single breath-hold and gated breathing imaging studies with adequate signal level and image contrast to extract regional lung ventilation information.
Conditions Studied
Interventions
- DRUG PFP
Study Locations (1)
North Carolina
- The University of North Carolina at Chapel Hill - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2015-07-01 |
| Est. Completion | 2018-12-31 |
| Phase | Early Phase 1 |
What the finished NCT03489590 record still lists
NCT03489590 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 42 participants, a relatively small participant target, below the 179-participant average among 169 other Cystic Fibrosis trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Cystic Fibrosis appearing as the primary indexed condition, and to 1 intervention - of which PFP is the first listed.
NCT03489590 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT03489590 about?
NCT03489590 is a clinical study titled "19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis". An open label non-randomized study enrolling up to 20 healthy participants and up to 30 participants with cystic fibrosis to establish a healthy versus disease comparison. Each participant will receive a mixture of inert gas (perfluoropropane (PFP)) in a ratio of 79% PFP to 21% oxygen as a contrast ...
What is the current status of trial NCT03489590?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 42 participants. The study started on 2015-07-01. Estimated completion is 2018-12-31.
What conditions does trial NCT03489590 study?
This clinical trial studies the following conditions: Cystic Fibrosis.
What interventions are being tested in trial NCT03489590?
The interventions under investigation include: PFP (DRUG).
Who is sponsoring clinical trial NCT03489590?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03489590 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cystic Fibrosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03489590's enrollment target sits among peer trials
42 97th of 169 higher than 71 of 169 other Cystic Fibrosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cystic Fibrosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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