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Cocaine Use Disorder clinical trials
15 of 27 indexed Cocaine Use Disorder trials are currently recruiting.
27 US clinical trials · 15 currently recruiting
Cocaine Use Disorder is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is The University of Texas Health Science Center, Houston, running 4 of these trials.
The research picture
Cocaine Use Disorder has 27 registered US clinical trials, 15 of them open to new participants right now, about 56% of the total.
- 15
- recruiting participants now
- 56%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 4
- top sponsor: The University of Texas Health Science Center, Houston
Active & Recent Trials
27 total, page 1 of 1
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Wake Forest University Health Sciences
NCT04927143
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Cocaine Cue-reactivity Incubation Study
Icahn School of Medicine at Mount Sinai
NCT07091877
Treating Polysubstance Use Using a Novel Digital Technology
Friends Research Institute
NCT05766631
Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
Icahn School of Medicine at Mount Sinai
NCT07318480
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Yale University
NCT04721418
Imaging CRF X NOP Interactions in CUD
Rajesh Narendran
NCT05008146
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
The University of Texas Health Science Center, Houston
NCT07227948
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The University of Texas Health Science Center, Houston
NCT05986578
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The University of Texas Health Science Center, Houston
NCT04843046
Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
University of Maryland, Baltimore
NCT06691243
Cocaine and Pentoxifylline (BED IN 47)
William Stoops
NCT07086794
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
Rajesh Narendran
NCT05011760
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
William Stoops
NCT05610072
Safety Profile of Psilocybin for Cocaine Use Disorder
University of California, Los Angeles
NCT06102434
Contingency Management for Drug Use: Does Age Matter?
Wake Forest University Health Sciences
NCT05521854
Targeting Drug Memories With Methylphenidate
Icahn School of Medicine at Mount Sinai
NCT05978167
Temporal Window and Episodic Future Thinking in CUD
Virginia Polytechnic Institute and State University
NCT05507814
The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)
Yale University
NCT02174614
[11C]NOP-1A and Cocaine Use Disorders
University of Pittsburgh
NCT03348384
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03662529
Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
William Stoops
NCT02522325
Cocaine Opioid Oxytocin Option - Limited
University of California, San Francisco
NCT02028533
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
Virginia Commonwealth University
NCT02537873
Phase1, STP7 Cocaine Drug-Drug Interaction Study
Stalicla
NCT06273540
SXC-2023 Cocaine Interaction Study
National Institute on Drug Abuse (NIDA)
NCT06343532
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)
The University of Texas Health Science Center, Houston
NCT05631548
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 4 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cocaine Use Disorder Trial Landscape
27 indexed Cocaine Use Disorder studies · 15 recruiting (56%).
Phase mix: 1 late (III/IV) vs 17 early (I/II).
Top sponsor: The University of Texas Health Science Center, Houston (4 trials), 9 others listed. 27 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cocaine Use Disorder?
PlainTrial tracks 27 US clinical trials for Cocaine Use Disorder, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cocaine Use Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.