Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cocaine Use Disorder: early-phase trial registry
15 of 27 indexed Cocaine Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 15 currently recruiting · #598 of 28,707 conditions by registered trial count
Cocaine Use Disorder: 27 US clinical trials tracked, 15 recruiting.
Cocaine Use Disorder is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is The University of Texas Health Science Center, Houston, running 4 of these trials.
Enrollment posture brief
Registry condition cocaine-use-disorder
OPEN 15 | RECR 56% | LATE 1 | EARLY 17 | RANK #598 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Acute Lymphoblastic Leukemia, Pediatric (56% recruiting · 9 trials)
Cocaine Use Disorder lists 15 open slots (56% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cocaine Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cocaine Use Disorder is recruiting above its size-band peers.
15 of 27 indexed trials (55.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cocaine Use Disorder trials is spread across many organizations.
The University of Texas Health Science Center, Houston accounts for 4 of 27 trials (14.8%). 17 distinct sponsors appear on at least one study for this condition label.
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Most Cocaine Use Disorder trials plan to enrol fewer than 100 people.
Median target enrolment is 51 among the 27 trials that report a genuine target (sentinel values excluded). 20 of those (74.1%) plan for fewer than 100 participants.
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Cocaine Use Disorder research is mostly interventional.
26 interventional and 1 observational studies make up this index (96.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Wake Forest University Health Sciences
NCT04927143
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Cocaine Cue-reactivity Incubation Study
Icahn School of Medicine at Mount Sinai
NCT07091877
Treating Polysubstance Use Using a Novel Digital Technology
Friends Research Institute
NCT05766631
Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder
Icahn School of Medicine at Mount Sinai
NCT07318480
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Yale University
NCT04721418
Imaging CRF X NOP Interactions in CUD
Rajesh Narendran
NCT05008146
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
The University of Texas Health Science Center, Houston
NCT07227948
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The University of Texas Health Science Center, Houston
NCT05986578
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The University of Texas Health Science Center, Houston
NCT04843046
Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
University of Maryland, Baltimore
NCT06691243
Cocaine and Pentoxifylline (BED IN 47)
William Stoops
NCT07086794
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
Rajesh Narendran
NCT05011760
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
William Stoops
NCT05610072
Safety Profile of Psilocybin for Cocaine Use Disorder
University of California, Los Angeles
NCT06102434
Contingency Management for Drug Use: Does Age Matter?
Wake Forest University Health Sciences
NCT05521854
Targeting Drug Memories With Methylphenidate
Icahn School of Medicine at Mount Sinai
NCT05978167
Temporal Window and Episodic Future Thinking in CUD
Virginia Polytechnic Institute and State University
NCT05507814
The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)
Yale University
NCT02174614
[11C]NOP-1A and Cocaine Use Disorders
University of Pittsburgh
NCT03348384
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03662529
Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
William Stoops
NCT02522325
Cocaine Opioid Oxytocin Option - Limited
University of California, San Francisco
NCT02028533
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
Virginia Commonwealth University
NCT02537873
Phase1, STP7 Cocaine Drug-Drug Interaction Study
Stalicla
NCT06273540
SXC-2023 Cocaine Interaction Study
National Institute on Drug Abuse (NIDA)
NCT06343532
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)
The University of Texas Health Science Center, Houston
NCT05631548
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 4 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Cocaine Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cocaine Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cocaine Use Disorder page
27 registered trials, 15 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 15 Cocaine Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- The University of Texas Health Science Center, Houston sponsors the most Cocaine Use Disorder trials on record, review their full trial history before evaluating a specific study. See The University of Texas Health Science Center, Houston's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cocaine Use Disorder condition card totals 27 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.