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NCT05008146 · ClinicalTrials.gov registry record · Early Phase 1
Imaging CRF X NOP Interactions in CUD
A Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT05008146: Recruiting Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.
NCT05008146 is a Early Phase 1 study of Cocaine Use Disorder that is actively recruiting participants, run by Rajesh Narendran. The registered enrollment target is 80 participants, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05008146, a Early Phase 1 study of Cocaine Use Disorder, is actively recruiting participants, sponsored by Rajesh Narendran.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
Primary Outcome
VT is the volumes of distribution expressed relative to total plasma ligand concentration; Delta VT is the change in VT from baseline to 3-hours post-hydrocortisone.
Conditions Studied
Interventions
- DRUG Hydrocortisone
- RADIATION Baseline [C-11]NOP-1A PET Scan
- RADIATION Post-hydrocortisone [C-11]NOP-1A PET Scan
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2020-12-31 |
| Est. Completion | 2028-09-01 |
| Phase | Early Phase 1 |
What NCT05008146 shows while recruiting
NCT05008146 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower).
The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Hydrocortisone is the first listed.
NCT05008146 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05008146 about?
NCT05008146 is a clinical study titled "Imaging CRF X NOP Interactions in CUD". This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC...
What is the current status of trial NCT05008146?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 80 participants. The study started on 2020-12-31. Estimated completion is 2028-09-01.
What conditions does trial NCT05008146 study?
This clinical trial studies the following conditions: Cocaine Use Disorder.
What interventions are being tested in trial NCT05008146?
The interventions under investigation include: Hydrocortisone (DRUG), Baseline [C-11]NOP-1A PET Scan (RADIATION), Post-hydrocortisone [C-11]NOP-1A PET Scan (RADIATION).
Who is sponsoring clinical trial NCT05008146?
This trial is sponsored by Rajesh Narendran, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05008146 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05008146's enrollment target sits among peer trials
80 9th of 26 higher than 17 of 26 other Cocaine Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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