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NCT05008146 · ClinicalTrials.gov registry record · Early Phase 1

Imaging CRF X NOP Interactions in CUD

A Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.

Recruiting
Registry status
Early Phase 1
Development phase
80
Enrollment target
1
Study location

NCT05008146 is a Early Phase 1 study of Cocaine Use Disorder that is actively recruiting participants, run by Rajesh Narendran. The registered enrollment target is 80 participants, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05008146, a Early Phase 1 study of Cocaine Use Disorder, is actively recruiting participants, sponsored by Rajesh Narendran.

RECRUITING
Registry status
Early Phase 1
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.

Conditions Studied

Cocaine Use Disorder

Interventions

  • DRUG Hydrocortisone
  • RADIATION Baseline [C-11]NOP-1A PET Scan
  • RADIATION Post-hydrocortisone [C-11]NOP-1A PET Scan

Study Locations (1)

Pennsylvania

  • University of Pittsburgh - Pittsburgh

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2020-12-31
Est. Completion 2028-09-01
Phase Early Phase 1

Sponsor

Rajesh Narendran

5 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05008146

The ClinicalTrials.gov registry entry for NCT05008146 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower). The listed sponsor is Rajesh Narendran, which has 5 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Hydrocortisone is the first listed.

NCT05008146 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05008146 about?

NCT05008146 is a clinical study titled "Imaging CRF X NOP Interactions in CUD". This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC...

What is the current status of trial NCT05008146?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 80 participants. The study started on 2020-12-31. Estimated completion is 2028-09-01.

What conditions does trial NCT05008146 study?

This clinical trial studies the following conditions: Cocaine Use Disorder.

What interventions are being tested in trial NCT05008146?

The interventions under investigation include: Hydrocortisone (DRUG), Baseline [C-11]NOP-1A PET Scan (RADIATION), Post-hydrocortisone [C-11]NOP-1A PET Scan (RADIATION).

Who is sponsoring clinical trial NCT05008146?

This trial is sponsored by Rajesh Narendran, which has 5 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05008146 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.