Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02537873 · ClinicalTrials.gov registry record · Phase 1
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
A Phase 1 study of Cocaine Use Disorder, sponsored by Virginia Commonwealth University.
- Completed
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT02537873: Completed Phase 1 study of Cocaine Use Disorder, sponsored by Virginia Commonwealth University.
NCT02537873 is a Phase 1 study of Cocaine Use Disorder that has completed, run by Virginia Commonwealth University. The registered enrollment target is 29 participants, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02537873, a Phase 1 study of Cocaine Use Disorder, has completed, sponsored by Virginia Commonwealth University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self administration data) in non-treatment seeking cocaine use disorder subjects. The compound to be studied will be the 5-HT2CR agonist lorcaserin. Lorcaserin and other 5-HT2CR agonists have been shown to reduce cocaine self-administration and cue reactivity in rodents. In addition there is human safety data in non-cocaine using subjects for lorcaserin as it is currently FDA approved for obesity, and safety data from a cocaine interaction study in rodents , but there is no human cocaine interaction/PK data and no PD data to support potential dosages for phase II clinical trials.
Primary Outcome
Change in Heart rate (HR) measures during saline infusions will be compared to HR and BP after each cocaine infusion.
Conditions Studied
Interventions
- DRUG Placebo comparator
- DRUG Lorcaserin
- DRUG Cocaine Intravenous (IV)
Study Locations (1)
Virginia
- Virginia Commonwealth University, Institute for Drug and Alcohol Studies - Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2015-07 |
| Est. Completion | 2018-07-19 |
| Phase | Phase 1 |
What the finished NCT02537873 record still lists
NCT02537873 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (72% lower).
The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Placebo comparator is the first listed.
NCT02537873 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT02537873 about?
NCT02537873 is a clinical study titled "Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder". The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self administration data) in non-treatment seeking cocaine use disorder subjects. The compound to be studied will be ...
What is the current status of trial NCT02537873?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2015-07. Estimated completion is 2018-07-19.
What conditions does trial NCT02537873 study?
This clinical trial studies the following conditions: Cocaine Use Disorder.
What interventions are being tested in trial NCT02537873?
The interventions under investigation include: Placebo comparator (DRUG), Lorcaserin (DRUG), Cocaine Intravenous (IV) (DRUG).
Who is sponsoring clinical trial NCT02537873?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02537873 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02537873's enrollment target sits among peer trials
29 22nd of 26 higher than 5 of 26 other Cocaine Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
COMPLETED · Phase 1
-
Cocaine Opioid Oxytocin Option - Limited
COMPLETED · Phase 1
-
The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)
COMPLETED · Phase 1
-
Phase1, STP7 Cocaine Drug-Drug Interaction Study
COMPLETED · Phase 1
-
SXC-2023 Cocaine Interaction Study
COMPLETED · Phase 1
-
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02429557 · 29 participants · Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
- NCT02568878 · 29 participants · Phase 3
Creatine for Depressed Male and Female Methamphetamine Users
- NCT03014401 · 29 participants · NA
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
- NCT03128996 · 29 participants · Phase 1
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia