Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT02522325 · ClinicalTrials.gov registry record · Phase 1

Reinforcing Effects of Cocaine During Phendimetrazine Maintenance

A Phase 1 study of Cocaine Use Disorder, sponsored by William Stoops.

Completed
Registry status
Phase 1
Development phase
30
Enrollment target
1
Study location

NCT02522325: Completed Phase 1 study of Cocaine Use Disorder, sponsored by William Stoops.

NCT02522325 is a Phase 1 study of Cocaine Use Disorder that has completed, run by William Stoops. The registered enrollment target is 30 participants, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT02522325, a Phase 1 study of Cocaine Use Disorder, has completed, sponsored by William Stoops.

COMPLETED
Registry status
Phase 1
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

This study will determine the initial efficacy of phendimetrazine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.

Primary Outcome

The reinforcing effects of cocaine were determined using a modified progressive ratio procedure in which subjects made 10 choices between a portion of each available cocaine dose and money (US$0.25). Reinforcing effects are measured for each cocaine dose during both phendimetrazine and placebo maintenance.

Conditions Studied

Cocaine Use Disorder

Interventions

  • DRUG Placebo
  • DRUG Phendimetrazine
  • DRUG Cocaine

Study Locations (1)

Kentucky

  • University of Kentucky Department of Behavioral Science - Lexington

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2015-08
Est. Completion 2018-12
Phase Phase 1
William Stoops

13 total trials

What the finished NCT02522325 record still lists

NCT02522325 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower).

The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.

NCT02522325 reports a single indexed study location in Kentucky.

Frequently Asked Questions

What is clinical trial NCT02522325 about?

NCT02522325 is a clinical study titled "Reinforcing Effects of Cocaine During Phendimetrazine Maintenance". This study will determine the initial efficacy of phendimetrazine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and phen...

What is the current status of trial NCT02522325?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2015-08. Estimated completion is 2018-12.

What conditions does trial NCT02522325 study?

This clinical trial studies the following conditions: Cocaine Use Disorder.

What interventions are being tested in trial NCT02522325?

The interventions under investigation include: Placebo (DRUG), Phendimetrazine (DRUG), Cocaine (DRUG).

Who is sponsoring clinical trial NCT02522325?

This trial is sponsored by William Stoops, which has 13 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02522325 being conducted?

This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Cocaine Use Disorder

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT02522325's enrollment target sits among peer trials

30 18th of 26 higher than 6 of 26 other Cocaine Use Disorder trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Cocaine Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00977977 · 30 participants · Phase 2

    Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

  • NCT01459107 · 30 participants · Phase 2

    Human Upper Extremity Allotransplantation

  • NCT01666080 · 30 participants · NA

    Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)

  • NCT01720836 · 30 participants · Phase 1

    Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer

Similar registry start date

  • NCT05988463 · started 2027-01-01 · Phase 1

    Dose-Escalation Study of Artesunate Patients With IPF

  • NCT07219706 · started 2026-12-10 · NA

    Dietary Fiber and Time Restricted Eating

  • NCT02831335 · started 2026-12-01

    Technical Development of Multi-Parametric Renocerebral MRI

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

Related registry views

Source: ClinicalTrials.gov NCT02522325, the US trial registry maintained by the National Library of Medicine. NCT02522325 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.