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Acute Ischemic Stroke
Open-data reference.
27 US clinical trials · 12 currently recruiting
Active & Recent Trials
Brain, Blood And Clot or Tissue Registry And Collaboration
Justin Fraser
NCT03153683
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Corxel Pharmaceuticals
NCT06990867
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
Pharmazz
NCT05691244
SUMMIT RISE Study of Acute Ischemic Stroke Patients
Route 92 Medical
NCT07436156
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
Mercy Health Ohio
NCT05611242
Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)
Basking Biosciences
NCT06226805
The Pivotal Study of RapidPulseTM Aspiration System
RapidPulse
NCT06029491
Blood Pressure Variability and Ischemic Stroke Outcome
Yale University
NCT05756257
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
University of California, Los Angeles
NCT06440707
Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Ischemic Stroke Recovery (Pro00061930)
LCMC Health
NCT06148285
A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
Lumosa Therapeutics Co.
NCT05198323
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Washington University School of Medicine
NCT07404852
A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke
Shionogi
NCT05953480
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Dr. Michael D Hill
NCT05151172
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
University of Massachusetts, Worcester
NCT05671874
An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke
Jacobs institute
NCT06447116
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
University of Virginia
NCT01369069
Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)
PhotoThera
NCT01120301
Multi-arm Optimization of Stroke Thrombolysis
Washington University School of Medicine
NCT03735979
THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing
Penumbra
NCT05437055
Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial
Medtronic Neurovascular Clinical Affairs
NCT01657461
Imaging Guided Patient Selection for Interventional Revascularization Therapy
Penumbra
NCT00963989
Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke
Daiichi Sankyo
NCT02586233
C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions
University of Wisconsin, Madison
NCT03232151
Caffeinol Hypothermia Protocol
The University of Texas Health Science Center, Houston
NCT00299416
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
Lumosa Therapeutics Co.
NCT04091945
A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)
Astellas Pharma
NCT00044057
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 7 |
| Phase 3 | 5 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acute Ischemic Stroke Trial Landscape
ClinicalTrials.gov lists 27 US studies indexed under Acute Ischemic Stroke, and 12 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Acute Ischemic Stroke shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Acute Ischemic Stroke is led by Lumosa Therapeutics Co. with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 27 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acute Ischemic Stroke?
PlainTrial tracks 27 US clinical trials for Acute Ischemic Stroke, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acute Ischemic Stroke?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.