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Acute Ischemic Stroke: full-pipeline trial registry
12 of 27 indexed Acute Ischemic Stroke trials are currently recruiting.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 12 currently recruiting · #598 of 28,707 conditions by registered trial count
Acute Ischemic Stroke: 27 US clinical trials tracked, 12 recruiting.
Acute Ischemic Stroke is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Lumosa Therapeutics Co., running 2 of these trials.
Enrollment posture brief
Registry condition acute-ischemic-stroke
OPEN 12 | RECR 44% | LATE 6 | EARLY 9 | RANK #598 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Acute Undifferentiated Leukemia (44% recruiting · 9 trials)
Acute Ischemic Stroke lists 12 open slots (44% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Acute Ischemic Stroke on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Acute Ischemic Stroke is recruiting above its size-band peers.
12 of 27 indexed trials (44.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Acute Ischemic Stroke trials is spread across many organizations.
Lumosa Therapeutics Co. accounts for 2 of 27 trials (7.4%). 24 distinct sponsors appear on at least one study for this condition label.
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Typical Acute Ischemic Stroke enrolment sits around 196 participants.
Median target enrolment is 196 among the 26 trials that report a genuine target (sentinel values excluded). 7 of those (26.9%) plan for fewer than 100 participants.
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Acute Ischemic Stroke research is mostly interventional.
25 interventional and 2 observational studies make up this index (92.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
Brain, Blood And Clot or Tissue Registry And Collaboration
Justin Fraser
NCT03153683
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Corxel Pharmaceuticals
NCT06990867
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
Pharmazz
NCT05691244
SUMMIT RISE Study of Acute Ischemic Stroke Patients
Route 92 Medical
NCT07436156
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
Mercy Health Ohio
NCT05611242
Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)
Basking Biosciences
NCT06226805
The Pivotal Study of RapidPulseTM Aspiration System
RapidPulse
NCT06029491
Blood Pressure Variability and Ischemic Stroke Outcome
Yale University
NCT05756257
Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
University of California, Los Angeles
NCT06440707
Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Ischemic Stroke Recovery (Pro00061930)
LCMC Health
NCT06148285
A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
Lumosa Therapeutics Co.
NCT05198323
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Washington University School of Medicine
NCT07404852
A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke
Shionogi
NCT05953480
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
Dr. Michael D Hill
NCT05151172
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
University of Massachusetts, Worcester
NCT05671874
An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke
Jacobs institute
NCT06447116
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
University of Virginia
NCT01369069
Efficacy and Safety Trial of Transcranial Laser Therapy Within 24 Hours From Stroke Onset (NEST-3)
PhotoThera
NCT01120301
Multi-arm Optimization of Stroke Thrombolysis
Washington University School of Medicine
NCT03735979
THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing
Penumbra
NCT05437055
Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial
Medtronic Neurovascular Clinical Affairs
NCT01657461
Imaging Guided Patient Selection for Interventional Revascularization Therapy
Penumbra
NCT00963989
Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke
Daiichi Sankyo
NCT02586233
C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions
University of Wisconsin, Madison
NCT03232151
Caffeinol Hypothermia Protocol
The University of Texas Health Science Center, Houston
NCT00299416
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
Lumosa Therapeutics Co.
NCT04091945
A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)
Astellas Pharma
NCT00044057
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 7 |
| Phase 3 | 5 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Acute Ischemic Stroke records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Acute Ischemic Stroke trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Acute Ischemic Stroke page
27 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 12 Acute Ischemic Stroke trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Lumosa Therapeutics Co. sponsors the most Acute Ischemic Stroke trials on record, review their full trial history before evaluating a specific study. See Lumosa Therapeutics Co.'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Ischemic Stroke condition card totals 27 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.