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NCT05011760 · ClinicalTrials.gov registry record · Early Phase 1

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

A Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.

Recruiting
Registry status
Early Phase 1
Development phase
30
Enrollment target
1
Study location

NCT05011760 is a Early Phase 1 study of Cocaine Use Disorder that is actively recruiting participants, run by Rajesh Narendran. The registered enrollment target is 30 participants, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05011760, a Early Phase 1 study of Cocaine Use Disorder, is actively recruiting participants, sponsored by Rajesh Narendran.

RECRUITING
Registry status
Early Phase 1
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

Conditions Studied

Cocaine Use Disorder

Interventions

  • DRUG d-amphetamine
  • RADIATION Baseline [C-11]NPA PET Scan
  • RADIATION Post-amphetamine [C-11]NPA PET Scan

Study Locations (1)

Pennsylvania

  • University of PIttsburgh - Pittsburgh

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2021-01-31
Est. Completion 2028-09-01
Phase Early Phase 1

Sponsor

Rajesh Narendran

5 total trials

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What the Registry Record Tells You About NCT05011760

The ClinicalTrials.gov registry entry for NCT05011760 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower). The listed sponsor is Rajesh Narendran, which has 5 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which d-amphetamine is the first listed.

NCT05011760 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05011760 about?

NCT05011760 is a clinical study titled "[C-11]NPA PET-amphetamine in Cocaine Use Disorders". This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT m...

What is the current status of trial NCT05011760?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 30 participants. The study started on 2021-01-31. Estimated completion is 2028-09-01.

What conditions does trial NCT05011760 study?

This clinical trial studies the following conditions: Cocaine Use Disorder.

What interventions are being tested in trial NCT05011760?

The interventions under investigation include: d-amphetamine (DRUG), Baseline [C-11]NPA PET Scan (RADIATION), Post-amphetamine [C-11]NPA PET Scan (RADIATION).

Who is sponsoring clinical trial NCT05011760?

This trial is sponsored by Rajesh Narendran, which has 5 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05011760 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.