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NCT05011760 · ClinicalTrials.gov registry record · Early Phase 1
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
A Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05011760: Recruiting Early Phase 1 study of Cocaine Use Disorder, sponsored by Rajesh Narendran.
NCT05011760 is a Early Phase 1 study of Cocaine Use Disorder that is actively recruiting participants, run by Rajesh Narendran. The registered enrollment target is 30 participants, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05011760, a Early Phase 1 study of Cocaine Use Disorder, is actively recruiting participants, sponsored by Rajesh Narendran.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)
Primary Outcome
DELTA BPND is the change in BPND from the baseline PET scan to post-amphetamine PET scan that will be acquired 2.5 to 3 hours after d-amphetamine administration (0.5 mg/Kg, oral)
Conditions Studied
Interventions
- DRUG d-amphetamine
- RADIATION Baseline [C-11]NPA PET Scan
- RADIATION Post-amphetamine [C-11]NPA PET Scan
Study Locations (1)
Pennsylvania
- University of PIttsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2021-01-31 |
| Est. Completion | 2028-09-01 |
| Phase | Early Phase 1 |
What NCT05011760 shows while recruiting
NCT05011760 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 103-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (71% lower).
The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which d-amphetamine is the first listed.
NCT05011760 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05011760 about?
NCT05011760 is a clinical study titled "[C-11]NPA PET-amphetamine in Cocaine Use Disorders". This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT m...
What is the current status of trial NCT05011760?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 30 participants. The study started on 2021-01-31. Estimated completion is 2028-09-01.
What conditions does trial NCT05011760 study?
This clinical trial studies the following conditions: Cocaine Use Disorder.
What interventions are being tested in trial NCT05011760?
The interventions under investigation include: d-amphetamine (DRUG), Baseline [C-11]NPA PET Scan (RADIATION), Post-amphetamine [C-11]NPA PET Scan (RADIATION).
Who is sponsoring clinical trial NCT05011760?
This trial is sponsored by Rajesh Narendran, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05011760 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05011760's enrollment target sits among peer trials
30 18th of 26 higher than 6 of 26 other Cocaine Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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