Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04721418 · ClinicalTrials.gov registry record
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
A clinical trial of Cocaine Use Disorder and Healthy (Controls), sponsored by Yale University.
- Recruiting
- Registry status
- 80
- Enrollment target
- 1
- Study location
NCT04721418: Recruiting study of Cocaine Use Disorder and Healthy (Controls), sponsored by Yale University.
NCT04721418 is a study of Cocaine Use Disorder and Healthy (Controls) that is actively recruiting participants, run by Yale University. The registered enrollment target is 80 participants, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04721418, a study of Cocaine Use Disorder and Healthy (Controls), is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
Primary Outcome
Between-group comparisons of the fP-corrected total volume of distribution (VT/fP) in ACC.
Conditions Studied
Interventions
- RADIATION 11C-UCB-J
Study Locations (1)
Connecticut
- Connecticut Mental Health Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-07-20 |
| Est. Completion | 2026-06 |
What NCT04721418 shows while recruiting
NCT04721418 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (21% lower).
The record links to 2 conditions, with Cocaine Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which 11C-UCB-J is the first listed.
NCT04721418 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT04721418 about?
NCT04721418 is a clinical study titled "Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study". The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
What is the current status of trial NCT04721418?
This trial is currently recruiting. The enrollment target is 80 participants. The study started on 2021-07-20. Estimated completion is 2026-06.
What conditions does trial NCT04721418 study?
This clinical trial studies the following conditions: Cocaine Use Disorder, Healthy (Controls).
What interventions are being tested in trial NCT04721418?
The interventions under investigation include: 11C-UCB-J (RADIATION).
Who is sponsoring clinical trial NCT04721418?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04721418 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04721418's enrollment target sits among peer trials
80 9th of 26 higher than 17 of 26 other Cocaine Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cocaine Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
RECRUITING · Phase 2
-
Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
RECRUITING · Phase 2
-
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
RECRUITING · Phase 2
-
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
RECRUITING · NA
-
Cocaine Cue-reactivity Incubation Study
RECRUITING · NA
-
Cocaine and Pentoxifylline (BED IN 47)
RECRUITING · Early Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01243931 · 80 participants · NA
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
- NCT01659203 · 80 participants · Phase 1
Proton or Photon RT for Retroperitoneal Sarcomas
- NCT01803451 · 80 participants · Early Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
- NCT01964859 · 80 participants · Phase 2
Feasibility Study for Fibroblast Autologous Skin Grafts
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI