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NCT07227948 · ClinicalTrials.gov registry record · Phase 2

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder

A Phase 2 study of Cocaine Use Disorder, sponsored by The University of Texas Health Science Center, Houston.

Recruiting
Registry status
Phase 2
Development phase
75
Enrollment target
1
Study location

NCT07227948 is a Phase 2 study of Cocaine Use Disorder that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 75 participants, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (26% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07227948, a Phase 2 study of Cocaine Use Disorder, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.

RECRUITING
Registry status
Phase 2
Development phase
75 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CBT) for the treatment of cocaine use disorder (CUD). This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/).

Conditions Studied

Cocaine Use Disorder

Interventions

  • DRUG Placebo
  • DRUG Semaglutide
  • BEHAVIORAL cognitive behavioral therapy (CBT).

Study Locations (1)

Texas

  • The University of Texas Health Science Center at Houston - Houston

Trial Details

FieldValue
Enrollment Target 75 participants
Start Date 2026-01-15
Est. Completion 2029-02-28
Phase Phase 2

Sponsor

The University of Texas Health Science Center, Houston

732 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07227948

The ClinicalTrials.gov registry entry for NCT07227948 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 75 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 101-participant average among 26 other Cocaine Use Disorder trials with a reported enrollment target (26% lower). The listed sponsor is The University of Texas Health Science Center, Houston, which has 732 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Cocaine Use Disorder appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.

NCT07227948 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT07227948 about?

NCT07227948 is a clinical study titled "Repurposing Semaglutide for the Treatment of Cocaine Use Disorder". The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CBT) for the treatment of cocaine use disorder (CUD). This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (ht...

What is the current status of trial NCT07227948?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2026-01-15. Estimated completion is 2029-02-28.

What conditions does trial NCT07227948 study?

This clinical trial studies the following conditions: Cocaine Use Disorder.

What interventions are being tested in trial NCT07227948?

The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG), cognitive behavioral therapy (CBT). (BEHAVIORAL).

Who is sponsoring clinical trial NCT07227948?

This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07227948 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.