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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 4 of 7

ACTIVE NOT RECRUITING NA 260 participants

Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

Massachusetts General Hospital

NCT05373745

ACTIVE NOT RECRUITING NA 259 participants

Pain Care at Home to Amplify Function (Pain CHAMP)

Yale University

NCT05333341

ACTIVE NOT RECRUITING NA 250 participants

Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain

Saluda Medical Pty

NCT06229470

ACTIVE NOT RECRUITING NA 227 participants

The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)

Dana-Farber Cancer Institute

NCT05121558

ACTIVE NOT RECRUITING 220 participants

Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery

KK Women's and Children's Hospital

NCT03408717

ACTIVE NOT RECRUITING 200 participants

Retrospective PNS Study

Curonix

NCT06832449

ACTIVE NOT RECRUITING NA 198 participants

Development of STEPPT

San Diego State University

NCT06835439

ACTIVE NOT RECRUITING NA 185 participants

Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)

Nalu Medical

NCT05870124

ACTIVE NOT RECRUITING NA 177 participants

Paresthesia-Free Fast-Acting Subperception (FAST) Study

Boston Scientific Corporation

NCT04618471

ACTIVE NOT RECRUITING NA 160 participants

Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial

University of New Mexi

NCT05571917

ACTIVE NOT RECRUITING NA 157 participants

Pain and Opioids: Integrated Treatment In Veterans

University of New Mexi

NCT04648228

ACTIVE NOT RECRUITING Phase 2 142 participants

Compassion Meditation vs. Health Education for Veterans

VA Office of Research and Development

NCT04651296

ACTIVE NOT RECRUITING NA 100 participants

TMS-EEG Biomarkers for Chronic Pain

University of California, San Francisco

NCT07116278

ACTIVE NOT RECRUITING NA 100 participants

Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures

Lake Erie College of Osteopathic Medicine

NCT06235996

ACTIVE NOT RECRUITING NA 90 participants

Jazz Music and Mindfulness for Chronic Pain

University of California, Irvine

NCT05979012

ACTIVE NOT RECRUITING NA 89 participants

Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain

Nalu Medical

NCT05287373

ACTIVE NOT RECRUITING NA 80 participants

Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain

Massachusetts General Hospital

NCT03765879

ACTIVE NOT RECRUITING Phase 2 76 participants

Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief

Memorial Sloan Kettering Cancer Center

NCT05877521

ACTIVE NOT RECRUITING 72 participants

Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain

University of Kansas Medical Center

NCT04598035

ACTIVE NOT RECRUITING 64 participants

Effects of tDCS and tUS on Pain Perception in OA of the Knee

Spaulding Rehabilitation Hospital

NCT02723929

ACTIVE NOT RECRUITING 60 participants

Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes

Johns Hopkins University

NCT05450679

ACTIVE NOT RECRUITING Phase 2 60 participants

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

Northwestern University

NCT05463367

ACTIVE NOT RECRUITING NA 60 participants

Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain

Case Western Reserve University

NCT03625752

ACTIVE NOT RECRUITING 60 participants

Pancreatic Quantitative Sensory Testing (P-QST)

Children's Hospital Medical Center, Cincinnati

NCT06996535

ACTIVE NOT RECRUITING NA 55 participants

The Effect of Light Therapy on Chronic Pain

University of Arizona

NCT03677206

ACTIVE NOT RECRUITING NA 50 participants

TCI-Massage Clinical Trial

The Center for Victims of Torture, United States

NCT07482358

ACTIVE NOT RECRUITING 40 participants

Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain

Spaulding Rehabilitation Hospital

NCT02954432

ACTIVE NOT RECRUITING Phase 4 40 participants

Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

Stanford University

NCT06317636

ACTIVE NOT RECRUITING NA 39 participants

Probiotics for Inflammation in Pediatric Chronic Pain

Medical College of Wisconsin

NCT05141890

ACTIVE NOT RECRUITING Early Phase 1 36 participants

Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction

University of Kansas Medical Center

NCT04676399

ACTIVE NOT RECRUITING NA 35 participants

Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain

Stanford University

NCT05079984

ACTIVE NOT RECRUITING NA 30 participants

Green Light Exposure in Healthy Volunteers Exposure in Normal Human Volunteers

University of Arizona

NCT05295225

ACTIVE NOT RECRUITING 30 participants

Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain

Wake Forest University Health Sciences

NCT05674240

ACTIVE NOT RECRUITING NA 25 participants

Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).

Saint Francis Hospital

NCT06246526

ACTIVE NOT RECRUITING NA 15 participants

A Multi-component, Person-centered, and Yoga-based Coaching Program for Lupus Chronic Pain

University of Michigan

NCT07196072

ACTIVE NOT RECRUITING NA 7 participants

Comparing Long-term Effectiveness of High Frequency and Burst Spinal Cord Stimulation

Stanford University

NCT03681262

ACTIVE NOT RECRUITING NA 4 participants

Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain

Prasad Shirvalkar, MD, PhD

NCT03029884

COMPLETED 53,132 participants

Physician Coaching to Reduce Opioid-related Harms

University of Wisconsin, Madison

NCT02433496

COMPLETED 11,146 participants

Measuring Chronic Pain Impact: Measurement Enhancement for Chronic Pain

RAND

NCT04426812

COMPLETED NA 2,333 participants

Tailored Non-Pharmacotherapy Services for Chronic Pain

Kaiser Permanente

NCT04523714

COMPLETED Phase 2 699 participants

Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves

Tris Pharma

NCT01939366

COMPLETED 428 participants

Difficult Encounters in Pain Medicine

Johns Hopkins University

NCT05585619

COMPLETED NA 395 participants

Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated

VA Office of Research and Development

NCT03100539

COMPLETED 359 participants

Pain, Psychiatric Disorders, and Disability Among Veterans With and Without Polytrauma

US Department of Veterans Affairs

NCT00645970

COMPLETED NA 343 participants

Chronic Pain Skills Study

University of Washington

NCT02653664

COMPLETED NA 330 participants

Reducing the Transition From Acute to Chronic Musculoskeletal Pain Among Older Adults

University of North Carolina, Chapel Hill

NCT04118595

COMPLETED NA 316 participants

PNE Effectiveness Cluster Trial

University of Utah

NCT03168165

COMPLETED NA 286 participants

A Patient-Centered Intervention to Improve Opioid Safety

VA Office of Research and Development

NCT02791399

COMPLETED NA 278 participants

Improving the Management of Chronic Pain in Primary Care

University of Missouri-Columbia

NCT02783365

COMPLETED NA 270 participants

Do Discounted Vouchers for Medical Cannabis Reduce Opioid Use in Adults With Pain

Vireo Health

NCT04495725

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.