Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 4 of 7
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
Massachusetts General Hospital
NCT05373745
Pain Care at Home to Amplify Function (Pain CHAMP)
Yale University
NCT05333341
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
Saluda Medical Pty
NCT06229470
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Dana-Farber Cancer Institute
NCT05121558
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
KK Women's and Children's Hospital
NCT03408717
Retrospective PNS Study
Curonix
NCT06832449
Development of STEPPT
San Diego State University
NCT06835439
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)
Nalu Medical
NCT05870124
Paresthesia-Free Fast-Acting Subperception (FAST) Study
Boston Scientific Corporation
NCT04618471
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
University of New Mexi
NCT05571917
Pain and Opioids: Integrated Treatment In Veterans
University of New Mexi
NCT04648228
Compassion Meditation vs. Health Education for Veterans
VA Office of Research and Development
NCT04651296
TMS-EEG Biomarkers for Chronic Pain
University of California, San Francisco
NCT07116278
Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures
Lake Erie College of Osteopathic Medicine
NCT06235996
Jazz Music and Mindfulness for Chronic Pain
University of California, Irvine
NCT05979012
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
Nalu Medical
NCT05287373
Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain
Massachusetts General Hospital
NCT03765879
Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief
Memorial Sloan Kettering Cancer Center
NCT05877521
Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain
University of Kansas Medical Center
NCT04598035
Effects of tDCS and tUS on Pain Perception in OA of the Knee
Spaulding Rehabilitation Hospital
NCT02723929
Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
Johns Hopkins University
NCT05450679
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain
Case Western Reserve University
NCT03625752
Pancreatic Quantitative Sensory Testing (P-QST)
Children's Hospital Medical Center, Cincinnati
NCT06996535
The Effect of Light Therapy on Chronic Pain
University of Arizona
NCT03677206
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain
Spaulding Rehabilitation Hospital
NCT02954432
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
Stanford University
NCT06317636
Probiotics for Inflammation in Pediatric Chronic Pain
Medical College of Wisconsin
NCT05141890
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
University of Kansas Medical Center
NCT04676399
Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain
Stanford University
NCT05079984
Green Light Exposure in Healthy Volunteers Exposure in Normal Human Volunteers
University of Arizona
NCT05295225
Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
Wake Forest University Health Sciences
NCT05674240
Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).
Saint Francis Hospital
NCT06246526
A Multi-component, Person-centered, and Yoga-based Coaching Program for Lupus Chronic Pain
University of Michigan
NCT07196072
Comparing Long-term Effectiveness of High Frequency and Burst Spinal Cord Stimulation
Stanford University
NCT03681262
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Prasad Shirvalkar, MD, PhD
NCT03029884
Physician Coaching to Reduce Opioid-related Harms
University of Wisconsin, Madison
NCT02433496
Measuring Chronic Pain Impact: Measurement Enhancement for Chronic Pain
RAND
NCT04426812
Tailored Non-Pharmacotherapy Services for Chronic Pain
Kaiser Permanente
NCT04523714
Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves
Tris Pharma
NCT01939366
Difficult Encounters in Pain Medicine
Johns Hopkins University
NCT05585619
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
VA Office of Research and Development
NCT03100539
Pain, Psychiatric Disorders, and Disability Among Veterans With and Without Polytrauma
US Department of Veterans Affairs
NCT00645970
Chronic Pain Skills Study
University of Washington
NCT02653664
Reducing the Transition From Acute to Chronic Musculoskeletal Pain Among Older Adults
University of North Carolina, Chapel Hill
NCT04118595
PNE Effectiveness Cluster Trial
University of Utah
NCT03168165
A Patient-Centered Intervention to Improve Opioid Safety
VA Office of Research and Development
NCT02791399
Improving the Management of Chronic Pain in Primary Care
University of Missouri-Columbia
NCT02783365
Do Discounted Vouchers for Medical Cannabis Reduce Opioid Use in Adults With Pain
Vireo Health
NCT04495725
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.