Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Pain clinical trials
139 of 302 indexed Chronic Pain trials are currently recruiting.
302 US clinical trials · 139 currently recruiting
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.
- 139
- recruiting participants now
- 46%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
302 total, page 4 of 7
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
Massachusetts General Hospital
NCT05373745
Pain Care at Home to Amplify Function (Pain CHAMP)
Yale University
NCT05333341
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
Saluda Medical Pty
NCT06229470
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
Dana-Farber Cancer Institute
NCT05121558
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
KK Women's and Children's Hospital
NCT03408717
Retrospective PNS Study
Curonix
NCT06832449
Development of STEPPT
San Diego State University
NCT06835439
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)
Nalu Medical
NCT05870124
Paresthesia-Free Fast-Acting Subperception (FAST) Study
Boston Scientific Corporation
NCT04618471
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
University of New Mexi
NCT05571917
Pain and Opioids: Integrated Treatment In Veterans
University of New Mexi
NCT04648228
Compassion Meditation vs. Health Education for Veterans
VA Office of Research and Development
NCT04651296
TMS-EEG Biomarkers for Chronic Pain
University of California, San Francisco
NCT07116278
Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures
Lake Erie College of Osteopathic Medicine
NCT06235996
Jazz Music and Mindfulness for Chronic Pain
University of California, Irvine
NCT05979012
Clinical Study Of a Micro-Implantable Pulse Generator For The Treatment of Peripheral Neuropathic Pain
Nalu Medical
NCT05287373
Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain
Massachusetts General Hospital
NCT03765879
Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief
Memorial Sloan Kettering Cancer Center
NCT05877521
Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain
University of Kansas Medical Center
NCT04598035
Effects of tDCS and tUS on Pain Perception in OA of the Knee
Spaulding Rehabilitation Hospital
NCT02723929
Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
Johns Hopkins University
NCT05450679
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Northwestern University
NCT05463367
Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain
Case Western Reserve University
NCT03625752
Pancreatic Quantitative Sensory Testing (P-QST)
Children's Hospital Medical Center, Cincinnati
NCT06996535
The Effect of Light Therapy on Chronic Pain
University of Arizona
NCT03677206
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain
Spaulding Rehabilitation Hospital
NCT02954432
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
Stanford University
NCT06317636
Probiotics for Inflammation in Pediatric Chronic Pain
Medical College of Wisconsin
NCT05141890
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
University of Kansas Medical Center
NCT04676399
Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain
Stanford University
NCT05079984
Green Light Exposure in Healthy Volunteers Exposure in Normal Human Volunteers
University of Arizona
NCT05295225
Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
Wake Forest University Health Sciences
NCT05674240
Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).
Saint Francis Hospital
NCT06246526
A Multi-component, Person-centered, and Yoga-based Coaching Program for Lupus Chronic Pain
University of Michigan
NCT07196072
Comparing Long-term Effectiveness of High Frequency and Burst Spinal Cord Stimulation
Stanford University
NCT03681262
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Prasad Shirvalkar, MD, PhD
NCT03029884
Physician Coaching to Reduce Opioid-related Harms
University of Wisconsin, Madison
NCT02433496
Measuring Chronic Pain Impact: Measurement Enhancement for Chronic Pain
RAND
NCT04426812
Tailored Non-Pharmacotherapy Services for Chronic Pain
Kaiser Permanente
NCT04523714
Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves
Tris Pharma
NCT01939366
Difficult Encounters in Pain Medicine
Johns Hopkins University
NCT05585619
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
VA Office of Research and Development
NCT03100539
Pain, Psychiatric Disorders, and Disability Among Veterans With and Without Polytrauma
US Department of Veterans Affairs
NCT00645970
Chronic Pain Skills Study
University of Washington
NCT02653664
Reducing the Transition From Acute to Chronic Musculoskeletal Pain Among Older Adults
University of North Carolina, Chapel Hill
NCT04118595
PNE Effectiveness Cluster Trial
University of Utah
NCT03168165
A Patient-Centered Intervention to Improve Opioid Safety
VA Office of Research and Development
NCT02791399
Improving the Management of Chronic Pain in Primary Care
University of Missouri-Columbia
NCT02783365
Do Discounted Vouchers for Medical Cannabis Reduce Opioid Use in Adults With Pain
Vireo Health
NCT04495725
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Pain Trial Landscape
302 indexed Chronic Pain studies · 139 recruiting (46%).
Phase mix: 15 late (III/IV) vs 41 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Pain?
PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.