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NCT06317636 · ClinicalTrials.gov registry record · Phase 4
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
A Phase 4 study of Depression and Chronic Pain, sponsored by Stanford University.
- Active
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06317636: Active Phase 4 study of Depression and Chronic Pain, sponsored by Stanford University.
NCT06317636 is a Phase 4 study of Depression and Chronic Pain that is active but no longer recruiting, run by Stanford University. The registered enrollment target is 40 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06317636, a Phase 4 study of Depression and Chronic Pain, is active but no longer recruiting, sponsored by Stanford University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances. This study aims to: * Evaluate whether placebo is non-inferior to ketamine in treating chronic pain and depression, when delivered under propofol sedation * Confirm that propofol sedation is a safe way to keep participants blinded to treatment * Assess patients' comfort with the sedation process to improve future studies * Explore whether patient expectations affects their pain and depression Participants will: * Need to qualify for the study based on stringent medical criteria * Undergo sedation with propofol * Randomly receive either a ketamine or a placebo (saline) infusion during sedation * Complete several study assessments over 5-7 weeks
Primary Outcome
A numerical rating scale ranging from 0 (no pain) to 10 (worst possible pain) over the past 24 hours will be used to assess pain intensity.
Conditions Studied
Interventions
- DRUG Ketamine
- DRUG Normal saline
Study Locations (1)
California
- Stanford University - Stanford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-01-28 |
| Est. Completion | 2026-12 |
| Phase | Phase 4 |
What the registry record for NCT06317636 still lists
NCT06317636 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Ketamine is the first listed.
NCT06317636 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06317636 about?
NCT06317636 is a clinical study titled "Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression". The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances. This study aims to: * Evaluate whether p...
What is the current status of trial NCT06317636?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2025-01-28. Estimated completion is 2026-12.
What conditions does trial NCT06317636 study?
This clinical trial studies the following conditions: Depression, Chronic Pain.
What interventions are being tested in trial NCT06317636?
The interventions under investigation include: Ketamine (DRUG), Normal saline (DRUG).
Who is sponsoring clinical trial NCT06317636?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06317636 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06317636's enrollment target sits among peer trials
40 509th of 679 higher than 151 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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