Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05373745 · ClinicalTrials.gov registry record · NA
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
A NA study of Chronic Pain and Mild Cognitive Impairment, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- NA
- Development phase
- 260
- Enrollment target
- 1
- Study location
NCT05373745: Active NA study of Chronic Pain and Mild Cognitive Impairment, sponsored by Massachusetts General Hospital.
NCT05373745 is a NA study of Chronic Pain and Mild Cognitive Impairment that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 260 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05373745, a NA study of Chronic Pain and Mild Cognitive Impairment, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 260 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing) and chronic pain, Active Brains 1 and Active Brains 2. The investigators will assess how each program may help in improving multimodal physical, cognitive and emotional function. The investigators will also assess whether improvements in outcomes from the two programs are maintained through 6-months follow-up. The investigators will also explore whether improvements in outcomes are mediated by nonadaptive pain reactions, adaptive coping, social factors and compensatory strategies and modified by demographic and clinical predictors. Both programs will be delivered virtually (Zoom).
Primary Outcome
Change in rate of a participant's capability rather than performance of physical activities, with items ranging from 1-4. Higher T scores indicate greater physical function.
Conditions Studied
Interventions
- BEHAVIORAL Active Brains 1
- BEHAVIORAL Active Brains 2
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 260 participants |
| Start Date | 2022-06-20 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What the registry record for NCT05373745 still lists
NCT05373745 is an interventional study that assigns participants to a tested intervention. The registered 260 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (66% lower).
The record links to 4 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Active Brains 1 is the first listed.
NCT05373745 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05373745 about?
NCT05373745 is a clinical study titled "Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain". The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing) and chronic pain, Active Brains 1 and Active Brains 2. The investigator...
What is the current status of trial NCT05373745?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 260 participants. The study started on 2022-06-20. Estimated completion is 2026-12-31.
What conditions does trial NCT05373745 study?
This clinical trial studies the following conditions: Chronic Pain, Mild Cognitive Impairment, Physical Activity, Older Adults.
What interventions are being tested in trial NCT05373745?
The interventions under investigation include: Active Brains 1 (BEHAVIORAL), Active Brains 2 (BEHAVIORAL).
Who is sponsoring clinical trial NCT05373745?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05373745 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05373745's enrollment target sits among peer trials
260 63rd of 301 higher than 239 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software
RECRUITING · NA
-
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
RECRUITING · NA
-
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
RECRUITING · NA
-
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
RECRUITING · NA
-
Group-based Integrative Pain Management in Primary Care Safety Net Clinics
RECRUITING · NA
-
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02283996 · 260 participants · Phase 4
Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment
- NCT03276793 · 260 participants · NA
Brain Connectivity in Depression
- NCT03407469 · 260 participants
Measurement of Adherence and Health-Related Quality of Life, and Health-Care Resource Utilization
- NCT03713125 · 260 participants · NA
Executive Function in Early Childhood
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI