Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 5 of 7
Evidence-based Pain Intervention for Veterans: AtEase for Chronic Pain
Pro-Change Behavior Systems
NCT03963908
MEMO-Medical Marijuana and Opioids Study
Albert Einstein College of Medicine
NCT03268551
SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery
Boston Scientific Corporation
NCT04676022
Effectiveness of the Precision Spinal Cord Stimulator System at Sub-Perception Amplitude
Boston Scientific Corporation
NCT02314000
Single Session Class to Reduce Opioid Use in Chronic Pain
Stanford University
NCT03950791
Electrically Evoked Compound Action Potentials Human Observation Medtronic System Study (ECHO-MDT)
MedtronicNeuro
NCT06499220
Power Over Pain (POP) Study
University of Washington
NCT01800604
Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression
Boston Medical Center
NCT02262377
Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
University of Kansas Medical Center
NCT03444168
Managing Chronic Pain in Veterans With Substance Use Disorders
US Department of Veterans Affairs
NCT00982410
The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI
University of Washington
NCT03857672
Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain
VA Office of Research and Development
NCT01055639
Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain
Seattle Children's Hospital
NCT01496378
Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain
Endo Pharmaceuticals
NCT00226421
Mindfulness-Oriented Recovery Enhancement for Chronic Pain Patients Receiving Opioid Therapy
Florida State University
NCT01505101
Dual Treatment of Chronic Pain and Insomnia
Mary Free Bed Rehabilitation Hospital
NCT05033418
Football Players Health Study In Person Assessments Study
Massachusetts General Hospital
NCT03866564
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
University of Pittsburgh
NCT05003323
Digital Therapeutic for Chronic Pain Feasibility Study
University of Washington
NCT06000007
Virtual Reality in Inpatients
Cedars-Sinai Medical Center
NCT02456987
High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
Soovu Labs
NCT04109703
Effects of a Patient Driven Assessment Process With Complex Pain Patients
Kaiser Permanente
NCT02746354
Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.
Samueli Institute for Information Biology
NCT01752010
Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic
Ohio State University
NCT02244099
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
Evon Medics
NCT06218407
Mechanisms Of Change in Adolescent Pain Self-management
Seattle Children's Hospital
NCT04043962
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
The Pain App Study: A Novel Shared Decision Making Tool for People With Chronic Pain
Shared Decision Making Resources
NCT03425266
RestoreSensor Study
MedtronicNeuro
NCT01106404
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
Dartmouth-Hitchcock Medical Center
NCT03799471
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
Improving Functioning in Persons With Chronic Pain Post-SCI Through Virtual Classroom Education
Kessler Foundation
NCT02561676
Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease
University of Pittsburgh
NCT03029468
Virtual Empowered Relief for Chronic Pain
Stanford University
NCT05057988
A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Weill Medical College of Cornell University
NCT03265210
A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects
Centrexion Therapeutics
NCT04154501
Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults
Baylor University
NCT04785963
Phase II Pharmacokinetics Study of CAM2038
Braeburn Pharmaceuticals
NCT02710526
An Implantable Spinal Cord Stimulation Pain Management System
Boston Scientific Corporation
NCT00205855
StimRouter Registry Clinical Protocol
Bioness
NCT03913689
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Billings Clinic
NCT05001399
5-minute Mindful Pain Management Strategy
Florida State University
NCT06394765
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Rush University Medical Center
NCT05534126
Suicide Prevention for Patients With Chronic Pain
Veterans BioMedical Research Institute
NCT04490265
Tracking Physical Activity for Chronic Pain Management Among Older Adults in Detroit
University of Michigan
NCT03285958
Transforming Opioid Prescribing in Primary Care
Boston Medical Center
NCT01909076
Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study
MedtronicNeuro
NCT04765735
Positive Psychology for Chronic Pain Self-management
University of Michigan
NCT04321239
Brief Intervention for Chronic Pain and History of Stressful Experiences
Brigham and Women's Hospital
NCT06983327
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
University of Pittsburgh
NCT05182606
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.