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Chronic Pain clinical trials
139 of 302 indexed Chronic Pain trials are currently recruiting.
302 US clinical trials · 139 currently recruiting
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
The research picture
Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.
- 139
- recruiting participants now
- 46%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Active & Recent Trials
302 total, page 5 of 7
Evidence-based Pain Intervention for Veterans: AtEase for Chronic Pain
Pro-Change Behavior Systems
NCT03963908
MEMO-Medical Marijuana and Opioids Study
Albert Einstein College of Medicine
NCT03268551
SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery
Boston Scientific Corporation
NCT04676022
Effectiveness of the Precision Spinal Cord Stimulator System at Sub-Perception Amplitude
Boston Scientific Corporation
NCT02314000
Single Session Class to Reduce Opioid Use in Chronic Pain
Stanford University
NCT03950791
Electrically Evoked Compound Action Potentials Human Observation Medtronic System Study (ECHO-MDT)
MedtronicNeuro
NCT06499220
Power Over Pain (POP) Study
University of Washington
NCT01800604
Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression
Boston Medical Center
NCT02262377
Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
University of Kansas Medical Center
NCT03444168
Managing Chronic Pain in Veterans With Substance Use Disorders
US Department of Veterans Affairs
NCT00982410
The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI
University of Washington
NCT03857672
Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain
VA Office of Research and Development
NCT01055639
Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain
Seattle Children's Hospital
NCT01496378
Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain
Endo Pharmaceuticals
NCT00226421
Mindfulness-Oriented Recovery Enhancement for Chronic Pain Patients Receiving Opioid Therapy
Florida State University
NCT01505101
Dual Treatment of Chronic Pain and Insomnia
Mary Free Bed Rehabilitation Hospital
NCT05033418
Football Players Health Study In Person Assessments Study
Massachusetts General Hospital
NCT03866564
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
University of Pittsburgh
NCT05003323
Digital Therapeutic for Chronic Pain Feasibility Study
University of Washington
NCT06000007
Virtual Reality in Inpatients
Cedars-Sinai Medical Center
NCT02456987
High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
Soovu Labs
NCT04109703
Effects of a Patient Driven Assessment Process With Complex Pain Patients
Kaiser Permanente
NCT02746354
Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.
Samueli Institute for Information Biology
NCT01752010
Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic
Ohio State University
NCT02244099
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
Evon Medics
NCT06218407
Mechanisms Of Change in Adolescent Pain Self-management
Seattle Children's Hospital
NCT04043962
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
The Pain App Study: A Novel Shared Decision Making Tool for People With Chronic Pain
Shared Decision Making Resources
NCT03425266
RestoreSensor Study
MedtronicNeuro
NCT01106404
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
Dartmouth-Hitchcock Medical Center
NCT03799471
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
Improving Functioning in Persons With Chronic Pain Post-SCI Through Virtual Classroom Education
Kessler Foundation
NCT02561676
Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease
University of Pittsburgh
NCT03029468
Virtual Empowered Relief for Chronic Pain
Stanford University
NCT05057988
A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Weill Medical College of Cornell University
NCT03265210
A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects
Centrexion Therapeutics
NCT04154501
Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults
Baylor University
NCT04785963
Phase II Pharmacokinetics Study of CAM2038
Braeburn Pharmaceuticals
NCT02710526
An Implantable Spinal Cord Stimulation Pain Management System
Boston Scientific Corporation
NCT00205855
StimRouter Registry Clinical Protocol
Bioness
NCT03913689
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain
Billings Clinic
NCT05001399
5-minute Mindful Pain Management Strategy
Florida State University
NCT06394765
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Rush University Medical Center
NCT05534126
Suicide Prevention for Patients With Chronic Pain
Veterans BioMedical Research Institute
NCT04490265
Tracking Physical Activity for Chronic Pain Management Among Older Adults in Detroit
University of Michigan
NCT03285958
Transforming Opioid Prescribing in Primary Care
Boston Medical Center
NCT01909076
Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study
MedtronicNeuro
NCT04765735
Positive Psychology for Chronic Pain Self-management
University of Michigan
NCT04321239
Brief Intervention for Chronic Pain and History of Stressful Experiences
Brigham and Women's Hospital
NCT06983327
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
University of Pittsburgh
NCT05182606
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Pain Trial Landscape
302 indexed Chronic Pain studies · 139 recruiting (46%).
Phase mix: 15 late (III/IV) vs 41 early (I/II).
Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Pain?
PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.