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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 5 of 7

COMPLETED NA 268 participants

Evidence-based Pain Intervention for Veterans: AtEase for Chronic Pain

Pro-Change Behavior Systems

NCT03963908

COMPLETED 257 participants

MEMO-Medical Marijuana and Opioids Study

Albert Einstein College of Medicine

NCT03268551

COMPLETED NA 241 participants

SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery

Boston Scientific Corporation

NCT04676022

COMPLETED NA 229 participants

Effectiveness of the Precision Spinal Cord Stimulator System at Sub-Perception Amplitude

Boston Scientific Corporation

NCT02314000

COMPLETED NA 213 participants

Single Session Class to Reduce Opioid Use in Chronic Pain

Stanford University

NCT03950791

COMPLETED NA 201 participants

Electrically Evoked Compound Action Potentials Human Observation Medtronic System Study (ECHO-MDT)

MedtronicNeuro

NCT06499220

COMPLETED NA 177 participants

Power Over Pain (POP) Study

University of Washington

NCT01800604

COMPLETED NA 159 participants

Integrative Medicine Group Visits: A Patient-Centered Approach to Reducing Chronic Pain and Depression

Boston Medical Center

NCT02262377

COMPLETED 158 participants

Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome

University of Kansas Medical Center

NCT03444168

COMPLETED Early Phase 1 131 participants

Managing Chronic Pain in Veterans With Substance Use Disorders

US Department of Veterans Affairs

NCT00982410

COMPLETED NA 129 participants

The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI

University of Washington

NCT03857672

COMPLETED Phase 2 126 participants

Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain

VA Office of Research and Development

NCT01055639

COMPLETED NA 122 participants

Problem Solving Skills Training For Parent Caregivers of Youth With Chronic Pain

Seattle Children's Hospital

NCT01496378

COMPLETED Phase 3 120 participants

Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain

Endo Pharmaceuticals

NCT00226421

COMPLETED Phase 1 115 participants

Mindfulness-Oriented Recovery Enhancement for Chronic Pain Patients Receiving Opioid Therapy

Florida State University

NCT01505101

COMPLETED NA 114 participants

Dual Treatment of Chronic Pain and Insomnia

Mary Free Bed Rehabilitation Hospital

NCT05033418

COMPLETED 111 participants

Football Players Health Study In Person Assessments Study

Massachusetts General Hospital

NCT03866564

COMPLETED 110 participants

Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain

University of Pittsburgh

NCT05003323

COMPLETED Phase 3 108 participants

Digital Therapeutic for Chronic Pain Feasibility Study

University of Washington

NCT06000007

COMPLETED NA 100 participants

Virtual Reality in Inpatients

Cedars-Sinai Medical Center

NCT02456987

COMPLETED NA 100 participants

High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain

Soovu Labs

NCT04109703

COMPLETED NA 100 participants

Effects of a Patient Driven Assessment Process With Complex Pain Patients

Kaiser Permanente

NCT02746354

COMPLETED NA 98 participants

Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.

Samueli Institute for Information Biology

NCT01752010

COMPLETED NA 96 participants

Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic

Ohio State University

NCT02244099

COMPLETED Phase 1 86 participants

Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain

Evon Medics

NCT06218407

COMPLETED NA 85 participants

Mechanisms Of Change in Adolescent Pain Self-management

Seattle Children's Hospital

NCT04043962

COMPLETED Phase 2 83 participants

Gulf War Illness Inflammation Reduction Trial

Minneapolis Veterans Affairs Medical Center

NCT02506192

COMPLETED NA 80 participants

The Pain App Study: A Novel Shared Decision Making Tool for People With Chronic Pain

Shared Decision Making Resources

NCT03425266

COMPLETED NA 79 participants

RestoreSensor Study

MedtronicNeuro

NCT01106404

COMPLETED 77 participants

Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease

Dartmouth-Hitchcock Medical Center

NCT03799471

COMPLETED NA 76 participants

Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain

Syracuse University

NCT03996902

COMPLETED Phase 1 75 participants

Improving Functioning in Persons With Chronic Pain Post-SCI Through Virtual Classroom Education

Kessler Foundation

NCT02561676

COMPLETED NA 74 participants

Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease

University of Pittsburgh

NCT03029468

COMPLETED NA 73 participants

Virtual Empowered Relief for Chronic Pain

Stanford University

NCT05057988

COMPLETED NA 73 participants

A Behavioral Intervention for Depression and Chronic Pain in Primary Care

Weill Medical College of Cornell University

NCT03265210

COMPLETED Phase 1 68 participants

A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects

Centrexion Therapeutics

NCT04154501

COMPLETED NA 66 participants

Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults

Baylor University

NCT04785963

COMPLETED Phase 2 66 participants

Phase II Pharmacokinetics Study of CAM2038

Braeburn Pharmaceuticals

NCT02710526

COMPLETED Phase 3 65 participants

An Implantable Spinal Cord Stimulation Pain Management System

Boston Scientific Corporation

NCT00205855

COMPLETED 62 participants

StimRouter Registry Clinical Protocol

Bioness

NCT03913689

COMPLETED NA 60 participants

Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain

Billings Clinic

NCT05001399

COMPLETED NA 60 participants

5-minute Mindful Pain Management Strategy

Florida State University

NCT06394765

COMPLETED NA 60 participants

Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial

Rush University Medical Center

NCT05534126

COMPLETED NA 60 participants

Suicide Prevention for Patients With Chronic Pain

Veterans BioMedical Research Institute

NCT04490265

COMPLETED NA 57 participants

Tracking Physical Activity for Chronic Pain Management Among Older Adults in Detroit

University of Michigan

NCT03285958

COMPLETED NA 53 participants

Transforming Opioid Prescribing in Primary Care

Boston Medical Center

NCT01909076

COMPLETED NA 52 participants

Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study

MedtronicNeuro

NCT04765735

COMPLETED NA 51 participants

Positive Psychology for Chronic Pain Self-management

University of Michigan

NCT04321239

COMPLETED NA 50 participants

Brief Intervention for Chronic Pain and History of Stressful Experiences

Brigham and Women's Hospital

NCT06983327

COMPLETED NA 49 participants

Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy

University of Pittsburgh

NCT05182606

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.