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ClinicalTrials.gov 74 recruiting now official registry

Bladder Cancer clinical trials

Every US clinical trial registered for Bladder Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

179 US clinical trials · 74 currently recruiting

The research picture

Bladder Cancer has 179 registered US clinical trials, 74 of them open to new participants right now — about 41% of the total.

74
recruiting participants now
41%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 7,000 participants

Evaluation for NCI Surgery Branch Clinical Research Protocols

National Cancer Institute (NCI)

NCT00001823

RECRUITING 7,000 participants

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Adela

NCT05366881

RECRUITING 5,950 participants

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

National Cancer Institute (NCI)

NCT00026884

RECRUITING 4,400 participants

Blue Light Cystoscopy With Cysview® Registry

Photocure

NCT02660645

RECRUITING 2,000 participants

Measuring Surgical Recovery After Radical Cystectomy

M.D. Anderson Cancer Center

NCT03193970

RECRUITING 2,000 participants

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies

Elephas

NCT07327489

RECRUITING 1,100 participants

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

National Cancer Institute (NCI)

NCT04923178

RECRUITING NA 1,000 participants

Bladder Cancer Screening Trial

University of Texas Southwestern Medical Center

NCT05646485

RECRUITING 1,000 participants

Bladder Cancer Longitudinal Biorepository for Development of Novel Therapeutics/Biomarkers

University of Kansas Medical Center

NCT03413982

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francis

NCT05056077

RECRUITING 900 participants

A Novel Multiplex ELISA Assay for Evaluating Patients With Microscopic Hematuria for Bladder Cancer

Cedars-Sinai Medical Center

NCT03193541

RECRUITING Phase 2 740 participants

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT06172478

RECRUITING Phase 2 630 participants

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Daiichi Sankyo

NCT07129993

RECRUITING Phase 3 530 participants

A Study of Surgical Techniques During Cystectomy

Memorial Sloan Kettering Cancer Center

NCT06703476

RECRUITING 500 participants

Clinical Evaluation of BCDx for Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer

Early is Good

NCT05982561

RECRUITING NA 500 participants

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

UNC Lineberger Comprehensive Cancer Center

NCT06896162

RECRUITING 500 participants

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

National Cancer Institute (NCI)

NCT02379429

RECRUITING 416 participants

Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform

Elephas

NCT05520099

RECRUITING 408 participants

Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

University of Washington

NCT07225127

RECRUITING 400 participants

Predicting BCG Response

Cedars-Sinai Medical Center

NCT04564781

RECRUITING NA 320 participants

Improving Care for Rural Patients With Solid Tumors

University of Colorado, Denver

NCT04916990

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING Phase 1 310 participants

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Pfizer

NCT07090499

RECRUITING 300 participants

A Novel Multiplex ELISA Assay for Surveilling Patients With History of Bladder Cancer

Cedars-Sinai Medical Center

NCT03193515

RECRUITING Phase 1 260 participants

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

IDEAYA Biosciences

NCT07277413

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 241 participants

A Study to Evaluate the Safety and Tolerability of TOS-358 in Adults With HR+ Breast Cancer and Other Select Solid Tumors

Totus Medicines

NCT05683418

RECRUITING Phase 3 200 participants

Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection

Johns Hopkins University

NCT06525571

RECRUITING NA 194 participants

Comprehensive Optimization At-time of Radical Cystectomy Intervention

University of Texas Southwestern Medical Center

NCT05714826

RECRUITING 180 participants

Management of Cisplatin-Ineligible Patients With Metastatic Bladder Cancer and The Role of Geriatric Assessments

Dana-Farber Cancer Institute

NCT06138561

RECRUITING Phase 1 168 participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

OncoNano Medicine

NCT06022029

RECRUITING Phase 1 160 participants

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

EvolveImmune United

NCT07217171

RECRUITING Phase 2 150 participants

Telehealth Intervention for Ostomy Self-Management

City of Hope Medical Center

NCT06528990

RECRUITING Phase 1 150 participants

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

Tasca Therapeutics

NCT07030257

RECRUITING Phase 2 148 participants

Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery

The Methodist Hospital Research Institute

NCT07050771

RECRUITING Phase 3 136 participants

Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

Brigham and Women's Hospital

NCT03216525

RECRUITING NA 130 participants

Home Intravenous Fluid Infusion After Undergoing Radical Cystectomy

Johns Hopkins University

NCT07225205

RECRUITING NA 128 participants

A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients With Bladder Cancer and Upper Tract Urothelial Cancer, Get Moving Trial

University of Washington

NCT06040762

RECRUITING Phase 1 106 participants

Sacituzumab Govitecan Plus EV in Metastatic UC

Dana-Farber Cancer Institute

NCT04724018

RECRUITING 105 participants

ESPERANZA: External Control Arm Study for T-DXd for Patients With HER2 IHC3+ Solid Tumors

AstraZeneca

NCT06973161

RECRUITING Phase 1 100 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

National Cancer Institute (NCI)

NCT04235777

RECRUITING 100 participants

DESTINY-PANTUMOUR04

AstraZeneca

NCT07124000

RECRUITING NA 85 participants

Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy

University of Chicago

NCT06427824

RECRUITING 80 participants

Gender Related Coping and Survivorship for Genitourinary Cancers

Johns Hopkins University

NCT05649306

RECRUITING NA 70 participants

CONFIRM: Magnetic Resonance Guided Radiation Therapy

Brigham and Women's Hospital

NCT04368702

RECRUITING NA 70 participants

Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy

Thomas Jefferson University

NCT07234968

RECRUITING NA 70 participants

Evaluating Safety and Efficacy of Prostate-sparing Radical Cystectomy

Johns Hopkins University

NCT05792722

RECRUITING Phase 2 63 participants

Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05312671

RECRUITING NA 60 participants

Bladder Fiducial Markers and Multiparametric-MRI (Mp-MRI) to Optimize Bladder Chemo-radiotherapy

Cedars-Sinai Medical Center

NCT04442724

RECRUITING Phase 1 55 participants

KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)

Merck Sharp & Dohme

NCT07232602

RECRUITING Phase 1 55 participants

Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder

Noah Hahn, M.D.

NCT03317158

RECRUITING NA 54 participants

Image-Guided Gynecologic Brachytherapy

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02993900

RECRUITING NA 50 participants

Intravesical Treatment of Bladder Cancer at Home, Multi-modal Treatment Support

University of Pennsylvania

NCT07048496

RECRUITING NA 50 participants

Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial

Medical College of Wisconsin

NCT07227077

RECRUITING Phase 2 48 participants

Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer

University of Kansas Medical Center

NCT06493370

RECRUITING Phase 1 47 participants

Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer

University of California, San Francis

NCT06470282

RECRUITING Phase 1 45 participants

A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)

Merck Sharp & Dohme

NCT07222488

RECRUITING Phase 1 45 participants

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

Baylor College of Medicine

NCT03740256

RECRUITING Phase 2 36 participants

Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)

Columbia University

NCT06571708

RECRUITING Phase 2 34 participants

Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer

University of Florida

NCT06488222

RECRUITING Phase 1 30 participants

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

University of Arizona

NCT06814496

RECRUITING NA 30 participants

Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

University of Virginia

NCT05790850

RECRUITING 30 participants

Metabolism Evaluation Through Resting Indirect Calorimetry in Bladder Cancer (METRICS)

University of Kansas Medical Center

NCT06721260

RECRUITING 25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

National Cancer Institute (NCI)

NCT04235764

RECRUITING NA 25 participants

Patient-Centered Surgical Prehabilitation

Dana-Farber Cancer Institute

NCT05715684

RECRUITING NA 23 participants

Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion

Icahn School of Medicine at Mount Sinai

NCT06689176

RECRUITING Phase 1 20 participants

A Study of 68Gallium PSMA-PET/CT Scans in People With Bladder Cancer or Skin Cancer

Memorial Sloan Kettering Cancer Center

NCT05562791

RECRUITING 20 participants

LaserEn: SOLTIVE™ Thulium Laser Fiber En Bloc Resection of Bladder Tumors

University of Kansas Medical Center

NCT04979156

RECRUITING Phase 2 20 participants

Renal Retention in High Grade Upper Tract Urothelial Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05656235

RECRUITING Phase 1 19 participants

Enfortumab Vedotin and Stereotactic Radiation for Localized, Cisplatin Ineligible Muscle Invasive Bladder Cancer

University of Texas Southwestern Medical Center

NCT06394570

RECRUITING 16 participants

Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma

Fox Chase Cancer Center

NCT03291028

RECRUITING Phase 1 10 participants

Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

Abramson Cancer Center at Penn Medicine

NCT06586255

RECRUITING NA 10 participants

A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest

Dana-Farber Cancer Institute

NCT05899361

RECRUITING NA 5 participants

Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study

University of California, Los Angeles

NCT06337942

ACTIVE NOT RECRUITING NA 21,081 participants

Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00579514

ACTIVE NOT RECRUITING 6,086 participants

Genetic Susceptibility to Bladder Cancer

M.D. Anderson Cancer Center

NCT00848289

ACTIVE NOT RECRUITING 5,000 participants

Molecular Analysis Of Bladder Cancer

Lahey Clinic

NCT00871754

ACTIVE NOT RECRUITING 3,519 participants

A Genotype-Phenotype Urothelial Cancer Registry

Memorial Sloan Kettering Cancer Center

NCT00902590

ACTIVE NOT RECRUITING Phase 3 1,135 participants

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

Janssen Research & Development

NCT05714202

ACTIVE NOT RECRUITING 1,000 participants

Tempus Priority Study: A Pan-tumor Observational Study

Tempus AI

NCT05179824

ACTIVE NOT RECRUITING Phase 3 907 participants

Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

Merck Sharp & Dohme

NCT03924856

ACTIVE NOT RECRUITING Phase 1 702 participants

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

AstraZeneca

NCT04644068

ACTIVE NOT RECRUITING 600 participants

Determinants of Bladder Cancer Recurrence Study (The DETER Study)

Memorial Sloan Kettering Cancer Center

NCT02400944

ACTIVE NOT RECRUITING 570 participants

CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

University of Washington

NCT03933826

ACTIVE NOT RECRUITING 550 participants

Quality of Life in Patients With Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT00745355

ACTIVE NOT RECRUITING 450 participants

A Novel Multiplex ELISA Assay for Evaluating Patients With Gross Hematuria for Bladder Cancer

Cedars-Sinai Medical Center

NCT03193528

ACTIVE NOT RECRUITING 400 participants

MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment

Invitae Corporation

NCT05219734

ACTIVE NOT RECRUITING Phase 3 367 participants

A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT

CG Oncology

NCT06111235

ACTIVE NOT RECRUITING Phase 1 310 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

Tyra Biosciences

NCT05544552

ACTIVE NOT RECRUITING Phase 3 240 participants

A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer

UroGen Pharma

NCT05243550

ACTIVE NOT RECRUITING Phase 1 230 participants

A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

Merck Sharp & Dohme

NCT06305767

ACTIVE NOT RECRUITING Phase 2 200 participants

Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer

University of Utah

NCT03171025

ACTIVE NOT RECRUITING Phase 2 190 participants

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 (N-803) in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

ImmunityBio

NCT03022825

ACTIVE NOT RECRUITING Phase 2 184 participants

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03836352

ACTIVE NOT RECRUITING 173 participants

A Diagnostic for the Early Detection of Bladder Cancer

Cedars-Sinai Medical Center

NCT05347342

ACTIVE NOT RECRUITING NA 144 participants

Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)

Medtronic - MITG

NCT05696444

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING NA 133 participants

Computed Tomography Urography (CTU) vs Intravenous Urography (IVU) on Patients at Risk of Urothelial Tumors

M.D. Anderson Cancer Center

NCT00567684

ACTIVE NOT RECRUITING Phase 2 131 participants

Trial of Ado-Trastuzumab Emtansine for Patients With HER2 Amplified or Mutant Cancers

Memorial Sloan Kettering Cancer Center

NCT02675829

ACTIVE NOT RECRUITING Phase 3 99 participants

A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer

UroGen Pharma

NCT06331299

Phase Distribution

PhaseTrial count
Phase 1 39
Phase 2 45
Phase 3 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bladder Cancer Trial Landscape

ClinicalTrials.gov lists 179 US studies indexed under Bladder Cancer, and 74 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Bladder Cancer shows 14 late-stage studies (Phase 3 and Phase 4 combined) alongside 84 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Bladder Cancer is led by Memorial Sloan Kettering Cancer Center with 17 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bladder Cancer?

PlainTrial tracks 179 US clinical trials for Bladder Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bladder Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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