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A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
NCT07217171 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have been ineligible for treatment with these medications. Participants with advanced or metastatic cancer who meet all eligibility criteria may be eligible to participate in the study.
Conditions Studied
Interventions
- DRUG EVOLVE104
Study Locations (8)
California
- USC/Norris Comprehensive Cancer Center — Los Angeles
Connecticut
- Yale University Cancer Center — New Haven
Georgia
- The Winship Cancer Institute Emory University — Atlanta
Michigan
- START Midwest — Grand Rapids
New York
- Memorial Sloan Kettering Cancer Center — New York
Pennsylvania
- Thomas Jefferson University, Sidney Kimmel Cancer Center — Philadelphia
Tennessee
- SCRI — Nashville
Virginia
- Virginia Cancer Specialists — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2025-11-13 |
| Est. Completion | 2031-01-29 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07217171
The ClinicalTrials.gov registry entry for NCT07217171 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is EvolveImmune United, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Bladder Cancer appearing as the primary indexed condition, and to 1 intervention — of which EVOLVE104 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07217171 reports 8 study locations spanning 8 distinct geographic areas — top geographies include California, Connecticut, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07217171 about?
NCT07217171 is a clinical study titled "A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas". The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have been ineligible for treatment with these medications. Participants with ad...
What is the current status of trial NCT07217171?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 160 participants. The study started on 2025-11-13. Estimated completion is 2031-01-29.
What conditions does trial NCT07217171 study?
This clinical trial studies the following conditions: Bladder Cancer, Esophageal Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Anal Squamous Cell Carcinoma, Cutaneous Squamous Cell Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07217171?
The interventions under investigation include: EVOLVE104 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07217171?
This trial is sponsored by EvolveImmune United, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07217171 being conducted?
This trial has 8 study locations across California, Connecticut, Georgia, Michigan, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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