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ClinicalTrials.gov 74 recruiting now official registry

Bladder Cancer clinical trials

74 of 179 indexed Bladder Cancer trials are currently recruiting.

179 US clinical trials · 74 currently recruiting

Bladder Cancer is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 84 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.

The research picture

Bladder Cancer has 179 registered US clinical trials, 74 of them open to new participants right now, about 41% of the total.

74
recruiting participants now
41%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 139Phase 245Phase 314

Active & Recent Trials

179 total, page 2 of 4

RECRUITING Phase 1 55 participants

Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder

Noah Hahn, M.D.

NCT03317158

RECRUITING NA 54 participants

Image-Guided Gynecologic Brachytherapy

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02993900

RECRUITING NA 50 participants

Intravesical Treatment of Bladder Cancer at Home, Multi-modal Treatment Support

University of Pennsylvania

NCT07048496

RECRUITING NA 50 participants

Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial

Medical College of Wisconsin

NCT07227077

RECRUITING Phase 2 48 participants

Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer

University of Kansas Medical Center

NCT06493370

RECRUITING Phase 1 47 participants

Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer

University of California, San Francisco

NCT06470282

RECRUITING Phase 1 45 participants

A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)

Merck Sharp & Dohme

NCT07222488

RECRUITING Phase 1 45 participants

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

Baylor College of Medicine

NCT03740256

RECRUITING Phase 2 36 participants

Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)

Columbia University

NCT06571708

RECRUITING Phase 2 34 participants

Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer

University of Florida

NCT06488222

RECRUITING Phase 1 30 participants

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

University of Arizona

NCT06814496

RECRUITING NA 30 participants

Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

University of Virginia

NCT05790850

RECRUITING 30 participants

Metabolism Evaluation Through Resting Indirect Calorimetry in Bladder Cancer (METRICS)

University of Kansas Medical Center

NCT06721260

RECRUITING 25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

National Cancer Institute (NCI)

NCT04235764

RECRUITING NA 25 participants

Patient-Centered Surgical Prehabilitation

Dana-Farber Cancer Institute

NCT05715684

RECRUITING NA 23 participants

Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion

Icahn School of Medicine at Mount Sinai

NCT06689176

RECRUITING Phase 1 20 participants

A Study of 68Gallium PSMA-PET/CT Scans in People With Bladder Cancer or Skin Cancer

Memorial Sloan Kettering Cancer Center

NCT05562791

RECRUITING 20 participants

LaserEn: SOLTIVE™ Thulium Laser Fiber En Bloc Resection of Bladder Tumors

University of Kansas Medical Center

NCT04979156

RECRUITING Phase 2 20 participants

Renal Retention in High Grade Upper Tract Urothelial Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05656235

RECRUITING Phase 1 19 participants

Enfortumab Vedotin and Stereotactic Radiation for Localized, Cisplatin Ineligible Muscle Invasive Bladder Cancer

University of Texas Southwestern Medical Center

NCT06394570

RECRUITING 16 participants

Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma

Fox Chase Cancer Center

NCT03291028

RECRUITING Phase 1 10 participants

Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

Abramson Cancer Center at Penn Medicine

NCT06586255

RECRUITING NA 10 participants

A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest

Dana-Farber Cancer Institute

NCT05899361

RECRUITING NA 5 participants

Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study

University of California, Los Angeles

NCT06337942

ACTIVE NOT RECRUITING NA 21,081 participants

Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00579514

ACTIVE NOT RECRUITING 6,086 participants

Genetic Susceptibility to Bladder Cancer

M.D. Anderson Cancer Center

NCT00848289

ACTIVE NOT RECRUITING 5,000 participants

Molecular Analysis Of Bladder Cancer

Lahey Clinic

NCT00871754

ACTIVE NOT RECRUITING 3,519 participants

A Genotype-Phenotype Urothelial Cancer Registry

Memorial Sloan Kettering Cancer Center

NCT00902590

ACTIVE NOT RECRUITING Phase 3 1,135 participants

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

Janssen Research & Development

NCT05714202

ACTIVE NOT RECRUITING 1,000 participants

Tempus Priority Study: A Pan-tumor Observational Study

Tempus AI

NCT05179824

ACTIVE NOT RECRUITING Phase 3 907 participants

Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

Merck Sharp & Dohme

NCT03924856

ACTIVE NOT RECRUITING Phase 1 702 participants

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

AstraZeneca

NCT04644068

ACTIVE NOT RECRUITING 600 participants

Determinants of Bladder Cancer Recurrence Study (The DETER Study)

Memorial Sloan Kettering Cancer Center

NCT02400944

ACTIVE NOT RECRUITING 570 participants

CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

University of Washington

NCT03933826

ACTIVE NOT RECRUITING 550 participants

Quality of Life in Patients With Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT00745355

ACTIVE NOT RECRUITING 450 participants

A Novel Multiplex ELISA Assay for Evaluating Patients With Gross Hematuria for Bladder Cancer

Cedars-Sinai Medical Center

NCT03193528

ACTIVE NOT RECRUITING 400 participants

MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment

Invitae Corporation

NCT05219734

ACTIVE NOT RECRUITING Phase 3 367 participants

A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT

CG Oncology

NCT06111235

ACTIVE NOT RECRUITING Phase 1 310 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

Tyra Biosciences

NCT05544552

ACTIVE NOT RECRUITING Phase 3 240 participants

A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer

UroGen Pharma

NCT05243550

ACTIVE NOT RECRUITING Phase 1 230 participants

A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

Merck Sharp & Dohme

NCT06305767

ACTIVE NOT RECRUITING Phase 2 200 participants

Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer

University of Utah

NCT03171025

ACTIVE NOT RECRUITING Phase 2 190 participants

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 (N-803) in Patients With BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

ImmunityBio

NCT03022825

ACTIVE NOT RECRUITING Phase 2 184 participants

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03836352

ACTIVE NOT RECRUITING 173 participants

A Diagnostic for the Early Detection of Bladder Cancer

Cedars-Sinai Medical Center

NCT05347342

ACTIVE NOT RECRUITING NA 144 participants

Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)

Medtronic - MITG

NCT05696444

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING NA 133 participants

Computed Tomography Urography (CTU) vs Intravenous Urography (IVU) on Patients at Risk of Urothelial Tumors

M.D. Anderson Cancer Center

NCT00567684

ACTIVE NOT RECRUITING Phase 2 131 participants

Trial of Ado-Trastuzumab Emtansine for Patients With HER2 Amplified or Mutant Cancers

Memorial Sloan Kettering Cancer Center

NCT02675829

ACTIVE NOT RECRUITING Phase 3 99 participants

A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer

UroGen Pharma

NCT06331299

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Phase Distribution

PhaseTrial count
Phase 1 39
Phase 2 45
Phase 3 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bladder Cancer Trial Landscape

179 indexed Bladder Cancer studies · 74 recruiting (41%).

Phase mix: 14 late (III/IV) vs 84 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bladder Cancer?

PlainTrial tracks 179 US clinical trials for Bladder Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bladder Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.