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Age-related Macular Degeneration clinical trials
20 of 75 indexed Age-related Macular Degeneration trials are currently recruiting.
75 US clinical trials · 20 currently recruiting
Age-related Macular Degeneration is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 8 of these trials.
The research picture
Age-related Macular Degeneration has 75 registered US clinical trials, 20 of them open to new participants right now, about 27% of the total.
- 20
- recruiting participants now
- 27%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 8
- top sponsor: National Eye Institute (NEI)
Active & Recent Trials
75 total, page 1 of 2
Village-Integrated Eye Worker Trial II
University of California, San Francisco
NCT03752840
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Sanguine Biosciences
NCT05635266
Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)
University of Wisconsin, Madison
NCT06924021
National Eye Institute Biorepository for Retinal Diseases
National Eye Institute (NEI)
NCT01496625
High Resolution Retinal Imaging
University of Pennsylvania
NCT01866371
Stem Cell Ophthalmology Treatment Study II
MD Stem Cells
NCT03011541
A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Hoffmann-La Roche
NCT06961370
Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD
VisionCare
NCT05438732
Progression of Early Atrophic Lesions
University of Utah
NCT05959005
Visual Remapping to Aid Reading With Field Loss
University of Minnesota
NCT03848663
Adaptive Optics Imaging of Outer Retinal Diseases
Food and Drug Administration (FDA)
NCT05355415
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
Duke University
NCT06619405
Lutein, Zeaxathin, and Fish Oil Supplementation
Texas A&M University
NCT06489873
Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
AbbVie
NCT07160179
Effects of Goji vs. Fiber on Macular Degeneration
University of California, Davis
NCT06237127
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
Perceive Biotherapeutics
NCT06087458
The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
MCPHS University
NCT06593405
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
Astellas Institute for Regenerative Medicine
NCT03178149
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
Massachusetts Eye and Ear Infirmary
NCT04735263
The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
University of Rochester
NCT06319872
ForeseeHome NRich Registry
Notal Vision
NCT05690880
GARM II: A Study on the Genetics of Age-related Maculopathy
University of California, Los Angeles
NCT01115387
An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration
Genentech
NCT05300724
Study of Dark Adaptation in Age-Related Macular Degeneration
National Eye Institute (NEI)
NCT01352975
A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration
Novartis Pharmaceuticals
NCT05230537
Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals
Western University of Health Sciences
NCT05763940
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders
Outlook Therapeutics
NCT05112861
Age-Related Eye Disease Study (AREDS) Follow-Up
National Eye Institute (NEI)
NCT00594672
Impact of Non-Exudative Type 1 MNV on AMD Progression
University of Utah
NCT06125977
Dark Adaptation in Participants With Age-Related Macular Degeneration
National Eye Institute (NEI)
NCT03225131
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)
Icahn School of Medicine at Mount Sinai
NCT03963817
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
Perceive Biotherapeutics
NCT05380492
Evaluation of Kamuvudine-8 in Subjects With Geographic Atrophy
Michelle Abou-Jaoude
NCT06164587
Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration
Chengdu Origen Biotechnology Co.
NCT05657301
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
Hoffmann-La Roche
NCT02286089
NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular Degeneration
Elisigen
NCT05984927
A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration
Oxford BioMedica
NCT01678872
A Phase I, Open-label, Multicenter, Dose-Escalating Study to Evaluate the Safety and Tolerability of KH658 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration
Chengdu Origen Biotechnology Co.
NCT06825858
Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial
University of Pennsylvania
NCT00593450
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
Novartis Pharmaceuticals
NCT04005352
Functionally Validated Structural Endpoints for Early AMD
Cynthia Owsley
NCT04112667
AREDS 2 Ancillary Spectral Domain Optical Coherence Tomography Study
Duke University
NCT00734487
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)
Outlook Therapeutics
NCT03834753
Phase 2/3 Study of ALK-001 in Geographic Atrophy
Alkeus Pharmaceuticals
NCT03845582
A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders
Outlook Therapeutics
NCT04516278
ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA
Stealth BioTherapeutics
NCT03891875
Genetic Analysis of Chronic Central Serous Chorioretinopathy Masquerading as Neovascular AMD
Sequenom
NCT01880788
Genetic Study of Age-Related Macular Degeneration
National Eye Institute (NEI)
NCT00357578
Retinal and Retinal Pigment Epithelium (RPE) Autoimmunity in Age-related Macular Degeneration (AMD)
Lawrence S. Morse, MD
NCT00931489
Study on Visual Function Impairments in Dry Age-related Macular Degeneration
Duke University
NCT01822873
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Age-related Macular Degeneration Trial Landscape
75 indexed Age-related Macular Degeneration studies · 20 recruiting (27%).
Phase mix: 8 late (III/IV) vs 26 early (I/II).
Top sponsor: National Eye Institute (NEI) (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Age-related Macular Degeneration?
PlainTrial tracks 75 US clinical trials for Age-related Macular Degeneration, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Age-related Macular Degeneration?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.