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RECRUITING Phase 1

A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

NCT06961370 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to assess the ocular and systemic safety and tolerability of RO7669330 in participants with GA secondary to AMD in at least one eye in Part 1, or both eyes in Part 2, after multiple unilateral intravitreal (IVT) doses.

Interventions

  • DRUG RO7669330
  • DRUG Syfovre™
  • DRUG Izervay™

Study Locations (16)

Texas

  • Austin Clinical Research, LLC — Austin
  • Texas Retina Associates — Dallas
  • Retina Consultants of Texas Westover Hills Retina Center — San Antonio
  • Retina Consultants of Texas - (The Woodlands) — The Woodlands

California

  • Retina-Vitreous Associates Medical Group — Beverly Hills
  • Global Research Management — Glendale
  • Retinal Consultants Medical Group Inc - Parkcenter Drive — Sacramento

Arizona

  • Associated Retina Consultants - Phoenix - DocTrials - PPDS — Phoenix
  • Barnet Dulaney Perkins Eye Center — Sun City

Tennessee

  • Charles Retina Institute — Germantown
  • Tennessee Retina PC — Nashville

Georgia

  • Southeast Retina Center — Augusta

Maryland

  • Cumberland Valley Retina Consultants PC — Hagerstown

Missouri

  • The Retina Institute — St Louis

Oregon

  • Retina Northwest — Portland

Trial Details

FieldValue
Enrollment Target 132 participants
Start Date 2025-07-16
Est. Completion 2027-01-03
Phase Phase 1

Sponsor

Hoffmann-La Roche

758 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06961370

The ClinicalTrials.gov registry entry for NCT06961370 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 132 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Geographic Atrophy appearing as the primary indexed condition, and to 3 interventions — of which RO7669330 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06961370 reports 16 study locations spanning 9 distinct geographic areas — top geographies include Texas, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06961370 about?

NCT06961370 is a clinical study titled "A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)". The main purpose of this study is to assess the ocular and systemic safety and tolerability of RO7669330 in participants with GA secondary to AMD in at least one eye in Part 1, or both eyes in Part 2, after multiple unilateral intravitreal (IVT) doses.

What is the current status of trial NCT06961370?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 132 participants. The study started on 2025-07-16. Estimated completion is 2027-01-03.

What conditions does trial NCT06961370 study?

This clinical trial studies the following conditions: Geographic Atrophy, Age-related Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06961370?

The interventions under investigation include: RO7669330 (DRUG), Syfovre™ (DRUG), Izervay™ (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06961370?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06961370 being conducted?

This trial has 16 study locations across Arizona, California, Georgia, Maryland, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial